Associations between antidepressant resistance, risks of previous pain disorders, and risks of diagnostic conversion to bipolar disorder among adolescent and young adult patients with major depressive disorder
Background: Increasing studies have supported the relationship between pain disorders and treatment-resistant depression (TRD) or chronic pain disorders may possibly impact the clinical characteristics of major depressive disorder (MDD). Thus, this linkage has been seen as a potential clinical mark...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Taiwanese Journal of Psychiatry |
| Subjects: | |
| Online Access: | http://www.e-tjp.org/article.asp?issn=1028-3684;year=2023;volume=37;issue=2;spage=70;epage=77;aulast=Wu |
| _version_ | 1827861781370896384 |
|---|---|
| author | Ping- Chung Wu Shih- Jen Tsai Tzeng- Ji Chen Mu- Hong Chen |
| author_facet | Ping- Chung Wu Shih- Jen Tsai Tzeng- Ji Chen Mu- Hong Chen |
| author_sort | Ping- Chung Wu |
| collection | DOAJ |
| description | Background: Increasing studies have supported the relationship between pain disorders and treatment-resistant depression (TRD) or chronic pain disorders may possibly impact the clinical characteristics of major depressive disorder (MDD). Thus, this linkage has been seen as a potential clinical marker to predict diagnostic conversion to bipolar disorder (BD) among patients with MDD. Methods: With the Taiwan National Health Insurance Research Database, we enrolled 4,760 adolescent and young adult patients with TRD, 19,040 counterparts with antidepressant-responsive depression, and 19,040 age-/sex-/residence-/family income-matched controls. Then, we followed up on their conversion from MDD to BD from enrollment to the end of 2011. Results: The incidence of diagnostic progression from MDD to BD was significantly higher in the TRD group than the non-TRD group (30.5% versus 10.6%, p < 0.001). Logistic regression analysis with adjustment of demographic characteristics showed that the TRD group had the highest risks of previous migraine, tension headache, fibromyalgia, peripheral neuropathy, dysmenorrhea, and irritable bowel syndrome, followed by the non-TRD group, and then the control group (p < 0.05). In further analysis of those data stratified by diagnostic progression to BD, we found no consistent results among different subgroups. Conclusion: Clinicians should be aware of the higher risk of developing TRD in depressive patients with comorbid pain disorders such as migraine, tension headache, fibromyalgia, peripheral neuropathy, dysmenorrhea, and irritable bowel syndrome. Besides, we found no consistent results in predicting diagnostic conversion from MDD to BD when the rôle of these pain disorders was evaluated. |
| first_indexed | 2024-03-12T13:43:27Z |
| format | Article |
| id | doaj.art-bf15adcc62bf4306906a7cce7801bdd3 |
| institution | Directory Open Access Journal |
| issn | 1028-3684 2666-2078 |
| language | English |
| last_indexed | 2024-03-12T13:43:27Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Taiwanese Journal of Psychiatry |
| spelling | doaj.art-bf15adcc62bf4306906a7cce7801bdd32023-08-23T09:55:55ZengWolters Kluwer Medknow PublicationsTaiwanese Journal of Psychiatry1028-36842666-20782023-01-01372707710.4103/TPSY.TPSY_14_23Associations between antidepressant resistance, risks of previous pain disorders, and risks of diagnostic conversion to bipolar disorder among adolescent and young adult patients with major depressive disorderPing- Chung WuShih- Jen TsaiTzeng- Ji ChenMu- Hong ChenBackground: Increasing studies have supported the relationship between pain disorders and treatment-resistant depression (TRD) or chronic pain disorders may possibly impact the clinical characteristics of major depressive disorder (MDD). Thus, this linkage has been seen as a potential clinical marker to predict diagnostic conversion to bipolar disorder (BD) among patients with MDD. Methods: With the Taiwan National Health Insurance Research Database, we enrolled 4,760 adolescent and young adult patients with TRD, 19,040 counterparts with antidepressant-responsive depression, and 19,040 age-/sex-/residence-/family income-matched controls. Then, we followed up on their conversion from MDD to BD from enrollment to the end of 2011. Results: The incidence of diagnostic progression from MDD to BD was significantly higher in the TRD group than the non-TRD group (30.5% versus 10.6%, p < 0.001). Logistic regression analysis with adjustment of demographic characteristics showed that the TRD group had the highest risks of previous migraine, tension headache, fibromyalgia, peripheral neuropathy, dysmenorrhea, and irritable bowel syndrome, followed by the non-TRD group, and then the control group (p < 0.05). In further analysis of those data stratified by diagnostic progression to BD, we found no consistent results among different subgroups. Conclusion: Clinicians should be aware of the higher risk of developing TRD in depressive patients with comorbid pain disorders such as migraine, tension headache, fibromyalgia, peripheral neuropathy, dysmenorrhea, and irritable bowel syndrome. Besides, we found no consistent results in predicting diagnostic conversion from MDD to BD when the rôle of these pain disorders was evaluated.http://www.e-tjp.org/article.asp?issn=1028-3684;year=2023;volume=37;issue=2;spage=70;epage=77;aulast=Wubipolaritylinkage studynational health insurance research databasetaiwan |
| spellingShingle | Ping- Chung Wu Shih- Jen Tsai Tzeng- Ji Chen Mu- Hong Chen Associations between antidepressant resistance, risks of previous pain disorders, and risks of diagnostic conversion to bipolar disorder among adolescent and young adult patients with major depressive disorder Taiwanese Journal of Psychiatry bipolarity linkage study national health insurance research database taiwan |
| title | Associations between antidepressant resistance, risks of previous pain disorders, and risks of diagnostic conversion to bipolar disorder among adolescent and young adult patients with major depressive disorder |
| title_full | Associations between antidepressant resistance, risks of previous pain disorders, and risks of diagnostic conversion to bipolar disorder among adolescent and young adult patients with major depressive disorder |
| title_fullStr | Associations between antidepressant resistance, risks of previous pain disorders, and risks of diagnostic conversion to bipolar disorder among adolescent and young adult patients with major depressive disorder |
| title_full_unstemmed | Associations between antidepressant resistance, risks of previous pain disorders, and risks of diagnostic conversion to bipolar disorder among adolescent and young adult patients with major depressive disorder |
| title_short | Associations between antidepressant resistance, risks of previous pain disorders, and risks of diagnostic conversion to bipolar disorder among adolescent and young adult patients with major depressive disorder |
| title_sort | associations between antidepressant resistance risks of previous pain disorders and risks of diagnostic conversion to bipolar disorder among adolescent and young adult patients with major depressive disorder |
| topic | bipolarity linkage study national health insurance research database taiwan |
| url | http://www.e-tjp.org/article.asp?issn=1028-3684;year=2023;volume=37;issue=2;spage=70;epage=77;aulast=Wu |
| work_keys_str_mv | AT pingchungwu associationsbetweenantidepressantresistancerisksofpreviouspaindisordersandrisksofdiagnosticconversiontobipolardisorderamongadolescentandyoungadultpatientswithmajordepressivedisorder AT shihjentsai associationsbetweenantidepressantresistancerisksofpreviouspaindisordersandrisksofdiagnosticconversiontobipolardisorderamongadolescentandyoungadultpatientswithmajordepressivedisorder AT tzengjichen associationsbetweenantidepressantresistancerisksofpreviouspaindisordersandrisksofdiagnosticconversiontobipolardisorderamongadolescentandyoungadultpatientswithmajordepressivedisorder AT muhongchen associationsbetweenantidepressantresistancerisksofpreviouspaindisordersandrisksofdiagnosticconversiontobipolardisorderamongadolescentandyoungadultpatientswithmajordepressivedisorder |