Decreased Human Platelet Activation and Mouse Pulmonary Thrombosis by Rutaecarpine and Comparison of the Relative Effectiveness with BAY11-7082: Crucial Signals of p38-NF-κB

Decreased Human Platelet Activation and Mouse Pulmonary Thrombosis by Rutaecarpine and Comparison of the Relative Effectiveness with BAY11-7082: Crucial Signals of p38-NF-κB

Platelets play a critical role in arterial thrombosis. Rutaecarpine (RUT) was purified from <i>Tetradium ruticarpum</i>, a well-known Chinese medicine. This study examined the relative activity of RUT with NF-κB inhibitors in human platelets. BAY11-7082 (an inhibitor of IκB kinase [IKK])...

Descrición completa

Detalles Bibliográficos
Main Authors: Wei-Chieh Huang, Shaw-Min Hou, Ming-Ping Wu, Chih-Wei Hsia, Thanasekaran Jayakumar, Chih-Hsuan Hsia, Periyakali Saravana Bhavan, Chi-Li Chung, Joen-Rong Sheu
Formato: Artigo
Idioma:English
Publicado: MDPI AG 2022-01-01
Series:Molecules
Subjects:
DPPH
human platelets
p38 MAPK
NF-κB
pulmonary thrombosis
rutaecarpine
Acceso en liña:https://www.mdpi.com/1420-3049/27/2/476

Internet

https://www.mdpi.com/1420-3049/27/2/476

Títulos similares