Radioprotective effect of Malva sylvestris L. against radiation-induced liver, kidney and intestine damages in rat: A histopathological study
Background: Ionizing radiation (IR) is widely used in the treatment of cancer in radiotherapy. One of the main concerns of patients with gastrointestinal cancers undergoing radiotherapy is the harmful side effects of IR on normal tissues. The liver, kidney, and duodenum are usually exposed to high d...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Biochemistry and Biophysics Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405580823000365 |
| _version_ | 1797813753199198208 |
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| author | Rasool Azmoonfar Hossein Khosravi Hassan Rafieemehr Fatemeh Mirzaei Dara Dastan Mohamad Reza Ghiasvand Lavin Khorshidi Abdolazim Sedighi Pashaki |
| author_facet | Rasool Azmoonfar Hossein Khosravi Hassan Rafieemehr Fatemeh Mirzaei Dara Dastan Mohamad Reza Ghiasvand Lavin Khorshidi Abdolazim Sedighi Pashaki |
| author_sort | Rasool Azmoonfar |
| collection | DOAJ |
| description | Background: Ionizing radiation (IR) is widely used in the treatment of cancer in radiotherapy. One of the main concerns of patients with gastrointestinal cancers undergoing radiotherapy is the harmful side effects of IR on normal tissues. The liver, kidney, and duodenum are usually exposed to high doses of radiation in the treatment of some cancers in abdominal region radiotherapy. We aimed to assess the radioprotective effects of Malva sylvestris L. against IR damages to the abdominal region. Materials and methods: This current study was conducted on 45 rats divided randomly into nine groups of five: A) negative control group, B) sham group, C) irradiation group, D) mallow treatment-1(200gr/kg), E) mallow treatment-2(400gr/kg), F) mallow treatment-3(600gr/kg), G) mallow treatment-4(200gr/kg) plus irradiation, H) mallow treatment-5(400gr/kg) plus irradiation, I) mallow treatment-6(600gr/kg) plus irradiation. Irradiation was performed with a 6Gy x-ray. Histopathological evaluations were performed 10 days after irradiation. Results: The histopathological examination results confirmed that preventive therapy with the effective dose of mallow reduced the liver, kidney, and intestine damage induced by radiation. The dose of 400 mg/kg was more effective than other selected dose in improving the damage caused by irradiation in the studied tissues. Conclusion: This study concludes that Malva sylvestris L. contributed to significant improvements in radiation-induced histological parameters of the liver and kidney and, to a lesser extent, in the intestine. These results collectively indicate that mallow is an effective radioprotective agent. |
| first_indexed | 2024-03-13T07:57:26Z |
| format | Article |
| id | doaj.art-bf18401894534acb86f28fa0fdda0816 |
| institution | Directory Open Access Journal |
| issn | 2405-5808 |
| language | English |
| last_indexed | 2024-03-13T07:57:26Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj.art-bf18401894534acb86f28fa0fdda08162023-06-02T04:23:23ZengElsevierBiochemistry and Biophysics Reports2405-58082023-07-0134101455Radioprotective effect of Malva sylvestris L. against radiation-induced liver, kidney and intestine damages in rat: A histopathological studyRasool Azmoonfar0Hossein Khosravi1Hassan Rafieemehr2Fatemeh Mirzaei3Dara Dastan4Mohamad Reza Ghiasvand5Lavin Khorshidi6Abdolazim Sedighi Pashaki7Department of Radiology, School of Allied Medical Sciences, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Radiology, School of Allied Medical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran; Corresponding author. Department of Radiology, School of Allied Medical Sciences, Hamadan university of Medical Sciences, Hamadan, Iran.Department of Laboratory Sciences, School of Allied Medical Sciences, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Anatomical Sciences, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Pharmacognosy, School of Pharmacy, Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Radiology, School of Allied Medical Sciences, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Radiology, School of Allied Medical Sciences, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Radiooncology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IranBackground: Ionizing radiation (IR) is widely used in the treatment of cancer in radiotherapy. One of the main concerns of patients with gastrointestinal cancers undergoing radiotherapy is the harmful side effects of IR on normal tissues. The liver, kidney, and duodenum are usually exposed to high doses of radiation in the treatment of some cancers in abdominal region radiotherapy. We aimed to assess the radioprotective effects of Malva sylvestris L. against IR damages to the abdominal region. Materials and methods: This current study was conducted on 45 rats divided randomly into nine groups of five: A) negative control group, B) sham group, C) irradiation group, D) mallow treatment-1(200gr/kg), E) mallow treatment-2(400gr/kg), F) mallow treatment-3(600gr/kg), G) mallow treatment-4(200gr/kg) plus irradiation, H) mallow treatment-5(400gr/kg) plus irradiation, I) mallow treatment-6(600gr/kg) plus irradiation. Irradiation was performed with a 6Gy x-ray. Histopathological evaluations were performed 10 days after irradiation. Results: The histopathological examination results confirmed that preventive therapy with the effective dose of mallow reduced the liver, kidney, and intestine damage induced by radiation. The dose of 400 mg/kg was more effective than other selected dose in improving the damage caused by irradiation in the studied tissues. Conclusion: This study concludes that Malva sylvestris L. contributed to significant improvements in radiation-induced histological parameters of the liver and kidney and, to a lesser extent, in the intestine. These results collectively indicate that mallow is an effective radioprotective agent.http://www.sciencedirect.com/science/article/pii/S2405580823000365Malva sylvestris LHistopathologyRadiation-protective agentsRadiation injuries |
| spellingShingle | Rasool Azmoonfar Hossein Khosravi Hassan Rafieemehr Fatemeh Mirzaei Dara Dastan Mohamad Reza Ghiasvand Lavin Khorshidi Abdolazim Sedighi Pashaki Radioprotective effect of Malva sylvestris L. against radiation-induced liver, kidney and intestine damages in rat: A histopathological study Biochemistry and Biophysics Reports Malva sylvestris L Histopathology Radiation-protective agents Radiation injuries |
| title | Radioprotective effect of Malva sylvestris L. against radiation-induced liver, kidney and intestine damages in rat: A histopathological study |
| title_full | Radioprotective effect of Malva sylvestris L. against radiation-induced liver, kidney and intestine damages in rat: A histopathological study |
| title_fullStr | Radioprotective effect of Malva sylvestris L. against radiation-induced liver, kidney and intestine damages in rat: A histopathological study |
| title_full_unstemmed | Radioprotective effect of Malva sylvestris L. against radiation-induced liver, kidney and intestine damages in rat: A histopathological study |
| title_short | Radioprotective effect of Malva sylvestris L. against radiation-induced liver, kidney and intestine damages in rat: A histopathological study |
| title_sort | radioprotective effect of malva sylvestris l against radiation induced liver kidney and intestine damages in rat a histopathological study |
| topic | Malva sylvestris L Histopathology Radiation-protective agents Radiation injuries |
| url | http://www.sciencedirect.com/science/article/pii/S2405580823000365 |
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