Phase-Dependent Modulation of Signal Transmission in Cortical Networks through tACS-Induced Neural Oscillations
Oscillatory neural activity is considered a basis of signal transmission in brain networks. However, the causal role of neural oscillations in regulating cortico-cortical signal transmission has so far not been directly demonstrated. To date, due to methodological limitations, studies on the online...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-09-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnhum.2017.00471/full |
| _version_ | 1818302858686103552 |
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| author | Kristoffer D. Fehér Masahito Nakataki Yosuke Morishima Yosuke Morishima |
| author_facet | Kristoffer D. Fehér Masahito Nakataki Yosuke Morishima Yosuke Morishima |
| author_sort | Kristoffer D. Fehér |
| collection | DOAJ |
| description | Oscillatory neural activity is considered a basis of signal transmission in brain networks. However, the causal role of neural oscillations in regulating cortico-cortical signal transmission has so far not been directly demonstrated. To date, due to methodological limitations, studies on the online modulatory mechanisms of transcranial alternating current stimulation (tACS)-induced neural oscillations are confined to the primary motor cortex. To address the causal role of oscillatory activity in modulating cortico-cortical signal transmission, we have established a new method using concurrent tACS, transcranial magnetic stimulation (TMS) and electroencephalography (EEG). Through tACS, we introduced 6-Hz (theta) oscillatory activity in the human dorsolateral prefrontal cortex (DLPFC). During tACS, we applied single-pulse TMS over the DLPFC at different phases of tACS and assessed propagation of TMS-induced neural activity with EEG. We show that tACS-induced theta oscillations modulate the propagation of TMS-induced activity in a phase-dependent manner and that phase-dependent modulation is not simply explained by the instantaneous amplitude of tACS. The results demonstrate a phase-dependent modulatory mechanism of tACS at a cortical network level, which is consistent with a causal role of neural oscillations in regulating the efficacy of signal transmission in the brain. |
| first_indexed | 2024-12-13T05:45:35Z |
| format | Article |
| id | doaj.art-bf18d3786bbd43d5af278e48390d644d |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-13T05:45:35Z |
| publishDate | 2017-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-bf18d3786bbd43d5af278e48390d644d2022-12-21T23:57:40ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612017-09-011110.3389/fnhum.2017.00471285793Phase-Dependent Modulation of Signal Transmission in Cortical Networks through tACS-Induced Neural OscillationsKristoffer D. Fehér0Masahito Nakataki1Yosuke Morishima2Yosuke Morishima3Division of Systems Neuroscience of Psychopathology, Translational Research Centre, University Hospital of Psychiatry, University of Bern, Bern, SwitzerlandDivision of Systems Neuroscience of Psychopathology, Translational Research Centre, University Hospital of Psychiatry, University of Bern, Bern, SwitzerlandDivision of Systems Neuroscience of Psychopathology, Translational Research Centre, University Hospital of Psychiatry, University of Bern, Bern, SwitzerlandPRESTO, Japan Science and Technology Agency, Saitama, JapanOscillatory neural activity is considered a basis of signal transmission in brain networks. However, the causal role of neural oscillations in regulating cortico-cortical signal transmission has so far not been directly demonstrated. To date, due to methodological limitations, studies on the online modulatory mechanisms of transcranial alternating current stimulation (tACS)-induced neural oscillations are confined to the primary motor cortex. To address the causal role of oscillatory activity in modulating cortico-cortical signal transmission, we have established a new method using concurrent tACS, transcranial magnetic stimulation (TMS) and electroencephalography (EEG). Through tACS, we introduced 6-Hz (theta) oscillatory activity in the human dorsolateral prefrontal cortex (DLPFC). During tACS, we applied single-pulse TMS over the DLPFC at different phases of tACS and assessed propagation of TMS-induced neural activity with EEG. We show that tACS-induced theta oscillations modulate the propagation of TMS-induced activity in a phase-dependent manner and that phase-dependent modulation is not simply explained by the instantaneous amplitude of tACS. The results demonstrate a phase-dependent modulatory mechanism of tACS at a cortical network level, which is consistent with a causal role of neural oscillations in regulating the efficacy of signal transmission in the brain.http://journal.frontiersin.org/article/10.3389/fnhum.2017.00471/fullfunctional connectivityeffective connectivitytheta oscillationstranscranial magnetic stimulationtranscranial alternating current stimulationelectroencephalography |
| spellingShingle | Kristoffer D. Fehér Masahito Nakataki Yosuke Morishima Yosuke Morishima Phase-Dependent Modulation of Signal Transmission in Cortical Networks through tACS-Induced Neural Oscillations Frontiers in Human Neuroscience functional connectivity effective connectivity theta oscillations transcranial magnetic stimulation transcranial alternating current stimulation electroencephalography |
| title | Phase-Dependent Modulation of Signal Transmission in Cortical Networks through tACS-Induced Neural Oscillations |
| title_full | Phase-Dependent Modulation of Signal Transmission in Cortical Networks through tACS-Induced Neural Oscillations |
| title_fullStr | Phase-Dependent Modulation of Signal Transmission in Cortical Networks through tACS-Induced Neural Oscillations |
| title_full_unstemmed | Phase-Dependent Modulation of Signal Transmission in Cortical Networks through tACS-Induced Neural Oscillations |
| title_short | Phase-Dependent Modulation of Signal Transmission in Cortical Networks through tACS-Induced Neural Oscillations |
| title_sort | phase dependent modulation of signal transmission in cortical networks through tacs induced neural oscillations |
| topic | functional connectivity effective connectivity theta oscillations transcranial magnetic stimulation transcranial alternating current stimulation electroencephalography |
| url | http://journal.frontiersin.org/article/10.3389/fnhum.2017.00471/full |
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