The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection

The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection

The intestinal hormone, glucose-dependent insulinotropic polypeptide (GIP), is involved in important physiological functions, including postprandial blood glucose homeostasis, bone remodeling, and lipid metabolism. While mutations leading to physiological changes can be identified in large-scale seq...

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Bibliographic Details
Main Authors: Peter Lindquist, Lærke Smidt Gasbjerg, Jacek Mokrosinski, Jens Juul Holst, Alexander Sebastian Hauser, Mette Marie Rosenkilde
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Endocrinology
Subjects:
GIP - glucose-dependent insulinotropic peptide
missense variants
pharmacogenomics
GIPR
GPCR (G protein coupled receptor)
UK Biobank
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.891586/full

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