Macrophages as Promising Carriers for Nanoparticle Delivery in Anticancer Therapy
Anna Wróblewska, Agnieszka Szczygieł, Bożena Szermer-Olearnik, Elżbieta Pajtasz-Piasecka Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, PolandCorrespondence: Anna Wróblewska, Hirszfeld Institute of Immunology a...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-08-01
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| Series: | International Journal of Nanomedicine |
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| Online Access: | https://www.dovepress.com/macrophages-as-promising-carriers-for-nanoparticle-delivery-in-antican-peer-reviewed-fulltext-article-IJN |
| _version_ | 1797749940225572864 |
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| author | Wróblewska A Szczygieł A Szermer-Olearnik B Pajtasz-Piasecka E |
| author_facet | Wróblewska A Szczygieł A Szermer-Olearnik B Pajtasz-Piasecka E |
| author_sort | Wróblewska A |
| collection | DOAJ |
| description | Anna Wróblewska, Agnieszka Szczygieł, Bożena Szermer-Olearnik, Elżbieta Pajtasz-Piasecka Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, PolandCorrespondence: Anna Wróblewska, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, Wrocław, 53-114, Poland, Tel +48 71 3709928, Email anna.wroblewska@hirszfeld.plAbstract: Macrophages play a critical role in the immune response due to their ability to recognize and remove pathogens, as well as present antigens, which are involved in inflammation, but they are also one of the most abundant immune cell populations present in the tumor microenvironment. In recent years, macrophages have become promising cellular carriers for drug and nanoparticle delivery to the tumor microenvironment, mainly due to their natural properties such as biocompatibility, degradability, lack of immunogenicity, long half-life in circulation, crossing biological barriers, and the possibility of migration and accumulation at a site of inflammation such as a tumor. For the effectiveness of this therapeutic strategy, known as “Trojan horse”, it is important that the nanoparticles engulfed by macrophages do not affect their proper functioning. In our review, we discussed how the size, shape, chemical and mechanical properties of nanoparticles influence their internalization by macrophages. In addition, we described the promising research utilizing macrophages, their cell membranes and macrophage-derived exosomes as drug carriers in anticancer therapy. As a prospect of the wider use of this therapeutic strategy, we postulate its future application in boron delivery to the tumor environment in boron neutron capture therapy.Keywords: macrophages, cellular carriers, anticancer therapy, tumor microenvironment, boron neutron capture therapy |
| first_indexed | 2024-03-12T16:25:46Z |
| format | Article |
| id | doaj.art-bf18e37fac42478cbd6c3dd8521473fb |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-03-12T16:25:46Z |
| publishDate | 2023-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-bf18e37fac42478cbd6c3dd8521473fb2023-08-08T19:52:16ZengDove Medical PressInternational Journal of Nanomedicine1178-20132023-08-01Volume 184521453985756Macrophages as Promising Carriers for Nanoparticle Delivery in Anticancer TherapyWróblewska ASzczygieł ASzermer-Olearnik BPajtasz-Piasecka EAnna Wróblewska, Agnieszka Szczygieł, Bożena Szermer-Olearnik, Elżbieta Pajtasz-Piasecka Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, PolandCorrespondence: Anna Wróblewska, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, Wrocław, 53-114, Poland, Tel +48 71 3709928, Email anna.wroblewska@hirszfeld.plAbstract: Macrophages play a critical role in the immune response due to their ability to recognize and remove pathogens, as well as present antigens, which are involved in inflammation, but they are also one of the most abundant immune cell populations present in the tumor microenvironment. In recent years, macrophages have become promising cellular carriers for drug and nanoparticle delivery to the tumor microenvironment, mainly due to their natural properties such as biocompatibility, degradability, lack of immunogenicity, long half-life in circulation, crossing biological barriers, and the possibility of migration and accumulation at a site of inflammation such as a tumor. For the effectiveness of this therapeutic strategy, known as “Trojan horse”, it is important that the nanoparticles engulfed by macrophages do not affect their proper functioning. In our review, we discussed how the size, shape, chemical and mechanical properties of nanoparticles influence their internalization by macrophages. In addition, we described the promising research utilizing macrophages, their cell membranes and macrophage-derived exosomes as drug carriers in anticancer therapy. As a prospect of the wider use of this therapeutic strategy, we postulate its future application in boron delivery to the tumor environment in boron neutron capture therapy.Keywords: macrophages, cellular carriers, anticancer therapy, tumor microenvironment, boron neutron capture therapyhttps://www.dovepress.com/macrophages-as-promising-carriers-for-nanoparticle-delivery-in-antican-peer-reviewed-fulltext-article-IJNmacrophagescellular carriersanticancer therapytumor microenvironmentboron neutron capture therapy |
| spellingShingle | Wróblewska A Szczygieł A Szermer-Olearnik B Pajtasz-Piasecka E Macrophages as Promising Carriers for Nanoparticle Delivery in Anticancer Therapy International Journal of Nanomedicine macrophages cellular carriers anticancer therapy tumor microenvironment boron neutron capture therapy |
| title | Macrophages as Promising Carriers for Nanoparticle Delivery in Anticancer Therapy |
| title_full | Macrophages as Promising Carriers for Nanoparticle Delivery in Anticancer Therapy |
| title_fullStr | Macrophages as Promising Carriers for Nanoparticle Delivery in Anticancer Therapy |
| title_full_unstemmed | Macrophages as Promising Carriers for Nanoparticle Delivery in Anticancer Therapy |
| title_short | Macrophages as Promising Carriers for Nanoparticle Delivery in Anticancer Therapy |
| title_sort | macrophages as promising carriers for nanoparticle delivery in anticancer therapy |
| topic | macrophages cellular carriers anticancer therapy tumor microenvironment boron neutron capture therapy |
| url | https://www.dovepress.com/macrophages-as-promising-carriers-for-nanoparticle-delivery-in-antican-peer-reviewed-fulltext-article-IJN |
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