Prevention of Dry Socket with Ozone Oil-Based Gel after Inferior Third Molar Extraction: A Double-Blind Split-Mouth Randomized Placebo-Controlled Clinical Trial
Tooth extraction is followed by a sequence of elaborate local changes affecting hard and soft tissues. Dry socket (DS) can occur as intense pain around and in the extraction site, with an incidence from 1–4% after generic tooth extraction to 45% for mandibular third molars. Ozone therapy has gained...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/9/4/289 |
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| author | Alberto Materni Claudio Pasquale Eugenio Longo Massimo Frosecchi Stefano Benedicenti Matteo Bozzo Andrea Amaroli |
| author_facet | Alberto Materni Claudio Pasquale Eugenio Longo Massimo Frosecchi Stefano Benedicenti Matteo Bozzo Andrea Amaroli |
| author_sort | Alberto Materni |
| collection | DOAJ |
| description | Tooth extraction is followed by a sequence of elaborate local changes affecting hard and soft tissues. Dry socket (DS) can occur as intense pain around and in the extraction site, with an incidence from 1–4% after generic tooth extraction to 45% for mandibular third molars. Ozone therapy has gained attention in the medical field because of its success in the treatment of various diseases, its biocompatible properties and its fewer side effects or discomfort than drugs. To investigate the preventive effect of the sunflower oil-based ozone gel Ozosan<sup>®</sup> (Sanipan srl, Clivio (VA), Italy) on DS, a double-blind split-mouth randomized placebo-controlled clinical trial was conducted according to the CONSORT guidelines. Ozosan<sup>®</sup> or the placebo gel were put in the socket, and the gels were washed off 2 min later. In total, 200 patients were included in our study. The patient population comprised 87 Caucasian males and 113 Caucasian females. The mean age of the included patients was 33.1 ± 12.4 years. Ozosan reduced the incidence of DS after inferior third molar extraction from 21.5% of the control to 2% (<i>p</i> < 0.001). Concerning the dry socket epidemiology, the incidence was not significantly correlated with gender, smoking or mesioangular, vertical or distoangular Winter’s classification. Post hoc power calculation showed a power of 99.8% for this data, with alpha = 0.001. |
| first_indexed | 2024-03-11T05:00:27Z |
| format | Article |
| id | doaj.art-bf1ea47a62e44e668cca86128fe8bf23 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-11T05:00:27Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-bf1ea47a62e44e668cca86128fe8bf232023-11-17T19:21:20ZengMDPI AGGels2310-28612023-04-019428910.3390/gels9040289Prevention of Dry Socket with Ozone Oil-Based Gel after Inferior Third Molar Extraction: A Double-Blind Split-Mouth Randomized Placebo-Controlled Clinical TrialAlberto Materni0Claudio Pasquale1Eugenio Longo2Massimo Frosecchi3Stefano Benedicenti4Matteo Bozzo5Andrea Amaroli6Department of Surgical and Diagnostic Sciences (DISC), University of Genoa, 16132 Genoa, ItalyDepartment of Surgical and Diagnostic Sciences (DISC), University of Genoa, 16132 Genoa, ItalyDepartment of Surgical and Diagnostic Sciences (DISC), University of Genoa, 16132 Genoa, ItalyDepartment of Surgical and Diagnostic Sciences (DISC), University of Genoa, 16132 Genoa, ItalyDepartment of Surgical and Diagnostic Sciences (DISC), University of Genoa, 16132 Genoa, ItalyDepartment of Earth, Environmental and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, ItalyDepartment of Earth, Environmental and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, ItalyTooth extraction is followed by a sequence of elaborate local changes affecting hard and soft tissues. Dry socket (DS) can occur as intense pain around and in the extraction site, with an incidence from 1–4% after generic tooth extraction to 45% for mandibular third molars. Ozone therapy has gained attention in the medical field because of its success in the treatment of various diseases, its biocompatible properties and its fewer side effects or discomfort than drugs. To investigate the preventive effect of the sunflower oil-based ozone gel Ozosan<sup>®</sup> (Sanipan srl, Clivio (VA), Italy) on DS, a double-blind split-mouth randomized placebo-controlled clinical trial was conducted according to the CONSORT guidelines. Ozosan<sup>®</sup> or the placebo gel were put in the socket, and the gels were washed off 2 min later. In total, 200 patients were included in our study. The patient population comprised 87 Caucasian males and 113 Caucasian females. The mean age of the included patients was 33.1 ± 12.4 years. Ozosan reduced the incidence of DS after inferior third molar extraction from 21.5% of the control to 2% (<i>p</i> < 0.001). Concerning the dry socket epidemiology, the incidence was not significantly correlated with gender, smoking or mesioangular, vertical or distoangular Winter’s classification. Post hoc power calculation showed a power of 99.8% for this data, with alpha = 0.001.https://www.mdpi.com/2310-2861/9/4/289alveolar osteitisalveolar periostitisalveolar periostitidesalveolusdentalwisdom tooth |
| spellingShingle | Alberto Materni Claudio Pasquale Eugenio Longo Massimo Frosecchi Stefano Benedicenti Matteo Bozzo Andrea Amaroli Prevention of Dry Socket with Ozone Oil-Based Gel after Inferior Third Molar Extraction: A Double-Blind Split-Mouth Randomized Placebo-Controlled Clinical Trial Gels alveolar osteitis alveolar periostitis alveolar periostitides alveolus dental wisdom tooth |
| title | Prevention of Dry Socket with Ozone Oil-Based Gel after Inferior Third Molar Extraction: A Double-Blind Split-Mouth Randomized Placebo-Controlled Clinical Trial |
| title_full | Prevention of Dry Socket with Ozone Oil-Based Gel after Inferior Third Molar Extraction: A Double-Blind Split-Mouth Randomized Placebo-Controlled Clinical Trial |
| title_fullStr | Prevention of Dry Socket with Ozone Oil-Based Gel after Inferior Third Molar Extraction: A Double-Blind Split-Mouth Randomized Placebo-Controlled Clinical Trial |
| title_full_unstemmed | Prevention of Dry Socket with Ozone Oil-Based Gel after Inferior Third Molar Extraction: A Double-Blind Split-Mouth Randomized Placebo-Controlled Clinical Trial |
| title_short | Prevention of Dry Socket with Ozone Oil-Based Gel after Inferior Third Molar Extraction: A Double-Blind Split-Mouth Randomized Placebo-Controlled Clinical Trial |
| title_sort | prevention of dry socket with ozone oil based gel after inferior third molar extraction a double blind split mouth randomized placebo controlled clinical trial |
| topic | alveolar osteitis alveolar periostitis alveolar periostitides alveolus dental wisdom tooth |
| url | https://www.mdpi.com/2310-2861/9/4/289 |
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