A pathogenic germline BRCA2 variant in a patient with hypopharyngeal squamous cell carcinoma
Abstract Pathogenic germline BRCA2 variants may be associated with an increased risk of hypopharyngeal squamous cell carcinoma that is more responsive to chemoradiation and chemotherapeutics targeting defective double‐strand DNA repair.
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
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| Series: | Clinical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ccr3.3548 |
| _version_ | 1818437675321917440 |
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| author | Tatiana Correa Douglas E. Laux Henry T. Hoffman |
| author_facet | Tatiana Correa Douglas E. Laux Henry T. Hoffman |
| author_sort | Tatiana Correa |
| collection | DOAJ |
| description | Abstract Pathogenic germline BRCA2 variants may be associated with an increased risk of hypopharyngeal squamous cell carcinoma that is more responsive to chemoradiation and chemotherapeutics targeting defective double‐strand DNA repair. |
| first_indexed | 2024-12-14T17:28:26Z |
| format | Article |
| id | doaj.art-bf20a32bc1a14a3293f7296f6948d8f1 |
| institution | Directory Open Access Journal |
| issn | 2050-0904 |
| language | English |
| last_indexed | 2024-12-14T17:28:26Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj.art-bf20a32bc1a14a3293f7296f6948d8f12022-12-21T22:53:09ZengWileyClinical Case Reports2050-09042021-01-019142943210.1002/ccr3.3548A pathogenic germline BRCA2 variant in a patient with hypopharyngeal squamous cell carcinomaTatiana Correa0Douglas E. Laux1Henry T. Hoffman2Department of Otolaryngology – Head and Neck Surgery University of Iowa Iowa City IA USADepartment of Internal Medicine–Hematology, Oncology & Bone Marrow Transplant University of Iowa Iowa City IA USADepartment of Otolaryngology – Head and Neck Surgery University of Iowa Iowa City IA USAAbstract Pathogenic germline BRCA2 variants may be associated with an increased risk of hypopharyngeal squamous cell carcinoma that is more responsive to chemoradiation and chemotherapeutics targeting defective double‐strand DNA repair.https://doi.org/10.1002/ccr3.3548geneticshead and neckmolecular targeted therapiesoncologypharmacology |
| spellingShingle | Tatiana Correa Douglas E. Laux Henry T. Hoffman A pathogenic germline BRCA2 variant in a patient with hypopharyngeal squamous cell carcinoma Clinical Case Reports genetics head and neck molecular targeted therapies oncology pharmacology |
| title | A pathogenic germline BRCA2 variant in a patient with hypopharyngeal squamous cell carcinoma |
| title_full | A pathogenic germline BRCA2 variant in a patient with hypopharyngeal squamous cell carcinoma |
| title_fullStr | A pathogenic germline BRCA2 variant in a patient with hypopharyngeal squamous cell carcinoma |
| title_full_unstemmed | A pathogenic germline BRCA2 variant in a patient with hypopharyngeal squamous cell carcinoma |
| title_short | A pathogenic germline BRCA2 variant in a patient with hypopharyngeal squamous cell carcinoma |
| title_sort | pathogenic germline brca2 variant in a patient with hypopharyngeal squamous cell carcinoma |
| topic | genetics head and neck molecular targeted therapies oncology pharmacology |
| url | https://doi.org/10.1002/ccr3.3548 |
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