Epidemiologic investigation of juvenile rheumatoid arthritis: a ten-year study
Background: Juvenile Rheumatoid Arthritis (JRA) is the most common chronic pediat-ric rheumatologic disease. There is a wide range of variation in disease subgroup distri-bution and evolution according to different populations, environments and genetic pre-disposition. This study was designed to eva...
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Tehran University of Medical Sciences
2014-06-01
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| Series: | Tehran University Medical Journal |
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| Online Access: | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5212&slc_lang=en&sid=1 |
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| author | Abdolreza Malek Yahya Aghighi Behnam Parvisy Parvisy Seyed Reza Raeeskarami Vahid Ziaee |
| author_facet | Abdolreza Malek Yahya Aghighi Behnam Parvisy Parvisy Seyed Reza Raeeskarami Vahid Ziaee |
| author_sort | Abdolreza Malek |
| collection | DOAJ |
| description | Background: Juvenile Rheumatoid Arthritis (JRA) is the most common chronic pediat-ric rheumatologic disease. There is a wide range of variation in disease subgroup distri-bution and evolution according to different populations, environments and genetic pre-disposition. This study was designed to evaluate epidemiologic characteristics of JRA in Iran.
Methods: A cross-sectional studies was performed on children suffering from JRA ac-cording to American College of Rheumatology during 10 year (2002-2011). Patients' data was recorded in hospital questionnaires; Patients' age at the first presentation and time of diagnosis, sex, ethnicity, early clinical and constitutional presentations, joint in-volvement pattern and presence of associated diseases were evaluated.
Results: In this study, 171 children (91 boys and 80 girls) were enrolled. The mean age of patients was 5.2±3.5 years at the time of presentation and 5.7±3.6 years when the diagnosis was confirmed. The most common type of disease was polyarticular arthritis (41.9%). The prevalence of pauciarticular and systemic onset subtype were 31.6% and 19.3%, respectively. According to ethnicity, the most common incidence was seen in Fars and Turk populations respectively. The most common constitutional presentation was fever. Fever and morning stiffness was significantly higher in polyarticular pa-tients. Extra articular manifestation was seen in 40.4% patients. Among extra-articular manifestations, skin involvement was seen more than others. There was no correlation between sex and type of chronic arthritis. Uveitis was detected in 5.8% of our cases. The mean age was significantly higher in polyarticular group (6.04 year) in comparison to pauciarticular and systemic group (4.4 year in both groups) (P= 0.005). There was no correlation between sex and type of chronic arthritis.
Conclusion: The prevalence of JRA subgroups was different in Iran comparing with western countries and polyarticular disease was the most common subgroup in this study. Uveitis was less common in this study in comparison to studies in other coun-tries. There is no sex predilection in each subgroup of JRA. |
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| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-12-10T12:38:06Z |
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| series | Tehran University Medical Journal |
| spelling | doaj.art-bf2392a92db74e3a9eafc7ce6de563da2022-12-22T01:48:37ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222014-06-01723187193Epidemiologic investigation of juvenile rheumatoid arthritis: a ten-year studyAbdolreza Malek0Yahya Aghighi 1Behnam Parvisy Parvisy 2Seyed Reza Raeeskarami 3Vahid Ziaee 4 Department of Pediatrics, Va-lieasr Hospital, Tehran University of Medical Sciences, Tehran, Iran. Department of Pediatrics, Va-lieasr Hospital, Tehran University of Medical Sciences, Tehran, Iran. Department of Pediatrics, Va-lieasr Hospital, Tehran University of Medical Sciences, Tehran, Iran. Department of Pediatrics, Va-lieasr Hospital, Tehran University of Medical Sciences, Tehran, Iran. Pediatric Rheumatology Re-search Group, Rheumatolo-gyResearch Center, Tehran University of Medical Sciences, Tehran, Iran.Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran. Background: Juvenile Rheumatoid Arthritis (JRA) is the most common chronic pediat-ric rheumatologic disease. There is a wide range of variation in disease subgroup distri-bution and evolution according to different populations, environments and genetic pre-disposition. This study was designed to evaluate epidemiologic characteristics of JRA in Iran. Methods: A cross-sectional studies was performed on children suffering from JRA ac-cording to American College of Rheumatology during 10 year (2002-2011). Patients' data was recorded in hospital questionnaires; Patients' age at the first presentation and time of diagnosis, sex, ethnicity, early clinical and constitutional presentations, joint in-volvement pattern and presence of associated diseases were evaluated. Results: In this study, 171 children (91 boys and 80 girls) were enrolled. The mean age of patients was 5.2±3.5 years at the time of presentation and 5.7±3.6 years when the diagnosis was confirmed. The most common type of disease was polyarticular arthritis (41.9%). The prevalence of pauciarticular and systemic onset subtype were 31.6% and 19.3%, respectively. According to ethnicity, the most common incidence was seen in Fars and Turk populations respectively. The most common constitutional presentation was fever. Fever and morning stiffness was significantly higher in polyarticular pa-tients. Extra articular manifestation was seen in 40.4% patients. Among extra-articular manifestations, skin involvement was seen more than others. There was no correlation between sex and type of chronic arthritis. Uveitis was detected in 5.8% of our cases. The mean age was significantly higher in polyarticular group (6.04 year) in comparison to pauciarticular and systemic group (4.4 year in both groups) (P= 0.005). There was no correlation between sex and type of chronic arthritis. Conclusion: The prevalence of JRA subgroups was different in Iran comparing with western countries and polyarticular disease was the most common subgroup in this study. Uveitis was less common in this study in comparison to studies in other coun-tries. There is no sex predilection in each subgroup of JRA.http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5212&slc_lang=en&sid=1arthritis juvenile juvenile idiopathic arthritis uveitis epidemiology children |
| spellingShingle | Abdolreza Malek Yahya Aghighi Behnam Parvisy Parvisy Seyed Reza Raeeskarami Vahid Ziaee Epidemiologic investigation of juvenile rheumatoid arthritis: a ten-year study Tehran University Medical Journal arthritis juvenile juvenile idiopathic arthritis uveitis epidemiology children |
| title | Epidemiologic investigation of juvenile rheumatoid arthritis: a ten-year study |
| title_full | Epidemiologic investigation of juvenile rheumatoid arthritis: a ten-year study |
| title_fullStr | Epidemiologic investigation of juvenile rheumatoid arthritis: a ten-year study |
| title_full_unstemmed | Epidemiologic investigation of juvenile rheumatoid arthritis: a ten-year study |
| title_short | Epidemiologic investigation of juvenile rheumatoid arthritis: a ten-year study |
| title_sort | epidemiologic investigation of juvenile rheumatoid arthritis a ten year study |
| topic | arthritis juvenile juvenile idiopathic arthritis uveitis epidemiology children |
| url | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5212&slc_lang=en&sid=1 |
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