Alcohol Intake and Alcohol–SNP Interactions Associated with Prostate Cancer Aggressiveness
Excessive alcohol intake is a well-known modifiable risk factor for many cancers. It is still unclear whether genetic variants or single nucleotide polymorphisms (SNPs) can modify alcohol intake’s impact on prostate cancer (PCa) aggressiveness. The objective is to test the alcohol–SNP interactions o...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/3/553 |
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| author | Hui-Yi Lin Xinnan Wang Tung-Sung Tseng Yu-Hsiang Kao Zhide Fang Patricia E. Molina Chia-Ho Cheng Anders E. Berglund Rosalind A. Eeles Kenneth R. Muir Nora Pashayan Christopher A. Haiman Hermann Brenner Jong Y. Park The PRACTICAL Consortium |
| author_facet | Hui-Yi Lin Xinnan Wang Tung-Sung Tseng Yu-Hsiang Kao Zhide Fang Patricia E. Molina Chia-Ho Cheng Anders E. Berglund Rosalind A. Eeles Kenneth R. Muir Nora Pashayan Christopher A. Haiman Hermann Brenner Jong Y. Park The PRACTICAL Consortium |
| author_sort | Hui-Yi Lin |
| collection | DOAJ |
| description | Excessive alcohol intake is a well-known modifiable risk factor for many cancers. It is still unclear whether genetic variants or single nucleotide polymorphisms (SNPs) can modify alcohol intake’s impact on prostate cancer (PCa) aggressiveness. The objective is to test the alcohol–SNP interactions of the 7501 SNPs in the four pathways (angiogenesis, mitochondria, miRNA, and androgen metabolism-related pathways) associated with PCa aggressiveness. We evaluated the impacts of three excessive alcohol intake behaviors in 3306 PCa patients with European ancestry from the PCa Consortium. We tested the alcohol–SNP interactions using logistic models with the discovery-validation study design. All three excessive alcohol intake behaviors were not significantly associated with PCa aggressiveness. However, the interactions of excessive alcohol intake and three SNPs (rs13107662 [<i>CAMK2D</i>, <i>p</i> = 6.2 × 10<sup>−6</sup>], rs9907521 [<i>PRKCA,</i><i>p</i> = 7.1 × 10<sup>−5</sup>], and rs11925452 [<i>ROBO1, p</i> = 8.2 × 10<sup>−4</sup>]) were significantly associated with PCa aggressiveness. These alcohol–SNP interactions revealed contrasting effects of excessive alcohol intake on PCa aggressiveness according to the genotypes in the identified SNPs. We identified PCa patients with the rs13107662 (<i>CAMK2D</i>) AA genotype, the rs11925452 (<i>ROBO1</i>) AA genotype, and the rs9907521 (<i>PRKCA)</i> AG genotype were more vulnerable to excessive alcohol intake for developing aggressive PCa. Our findings support that the impact of excessive alcohol intake on PCa aggressiveness was varied by the selected genetic profiles. |
| first_indexed | 2024-03-09T06:01:37Z |
| format | Article |
| id | doaj.art-bf26fe906a6546f7912daaa567d4b9c4 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T06:01:37Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-bf26fe906a6546f7912daaa567d4b9c42023-12-03T12:09:01ZengMDPI AGJournal of Clinical Medicine2077-03832021-02-0110355310.3390/jcm10030553Alcohol Intake and Alcohol–SNP Interactions Associated with Prostate Cancer AggressivenessHui-Yi Lin0Xinnan Wang1Tung-Sung Tseng2Yu-Hsiang Kao3Zhide Fang4Patricia E. Molina5Chia-Ho Cheng6Anders E. Berglund7Rosalind A. Eeles8Kenneth R. Muir9Nora Pashayan10Christopher A. Haiman11Hermann Brenner12Jong Y. Park13The PRACTICAL ConsortiumBiostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USABiostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USABehavioral and Community Health Sciences Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USABehavioral and Community Health Sciences Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USABiostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USADepartment of Physiology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USABiostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USADepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USAThe Institute of Cancer Research, and The Royal Marsden NHS Foundation Trust, London SM2 5NG, UKDivision of Population Health, Health Services Research, and Primary Care, University of Manchester, Oxford Road, Manchester M13 9PT, UKDepartment of Applied Health Research, University College London, London WC1E 7HB, UKCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90015, USADivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), D-69120 Heidelberg, GermanyDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USAExcessive alcohol intake is a well-known modifiable risk factor for many cancers. It is still unclear whether genetic variants or single nucleotide polymorphisms (SNPs) can modify alcohol intake’s impact on prostate cancer (PCa) aggressiveness. The objective is to test the alcohol–SNP interactions of the 7501 SNPs in the four pathways (angiogenesis, mitochondria, miRNA, and androgen metabolism-related pathways) associated with PCa aggressiveness. We evaluated the impacts of three excessive alcohol intake behaviors in 3306 PCa patients with European ancestry from the PCa Consortium. We tested the alcohol–SNP interactions using logistic models with the discovery-validation study design. All three excessive alcohol intake behaviors were not significantly associated with PCa aggressiveness. However, the interactions of excessive alcohol intake and three SNPs (rs13107662 [<i>CAMK2D</i>, <i>p</i> = 6.2 × 10<sup>−6</sup>], rs9907521 [<i>PRKCA,</i><i>p</i> = 7.1 × 10<sup>−5</sup>], and rs11925452 [<i>ROBO1, p</i> = 8.2 × 10<sup>−4</sup>]) were significantly associated with PCa aggressiveness. These alcohol–SNP interactions revealed contrasting effects of excessive alcohol intake on PCa aggressiveness according to the genotypes in the identified SNPs. We identified PCa patients with the rs13107662 (<i>CAMK2D</i>) AA genotype, the rs11925452 (<i>ROBO1</i>) AA genotype, and the rs9907521 (<i>PRKCA)</i> AG genotype were more vulnerable to excessive alcohol intake for developing aggressive PCa. Our findings support that the impact of excessive alcohol intake on PCa aggressiveness was varied by the selected genetic profiles.https://www.mdpi.com/2077-0383/10/3/553alcohol intakeSNP interactionprostate cancer |
| spellingShingle | Hui-Yi Lin Xinnan Wang Tung-Sung Tseng Yu-Hsiang Kao Zhide Fang Patricia E. Molina Chia-Ho Cheng Anders E. Berglund Rosalind A. Eeles Kenneth R. Muir Nora Pashayan Christopher A. Haiman Hermann Brenner Jong Y. Park The PRACTICAL Consortium Alcohol Intake and Alcohol–SNP Interactions Associated with Prostate Cancer Aggressiveness Journal of Clinical Medicine alcohol intake SNP interaction prostate cancer |
| title | Alcohol Intake and Alcohol–SNP Interactions Associated with Prostate Cancer Aggressiveness |
| title_full | Alcohol Intake and Alcohol–SNP Interactions Associated with Prostate Cancer Aggressiveness |
| title_fullStr | Alcohol Intake and Alcohol–SNP Interactions Associated with Prostate Cancer Aggressiveness |
| title_full_unstemmed | Alcohol Intake and Alcohol–SNP Interactions Associated with Prostate Cancer Aggressiveness |
| title_short | Alcohol Intake and Alcohol–SNP Interactions Associated with Prostate Cancer Aggressiveness |
| title_sort | alcohol intake and alcohol snp interactions associated with prostate cancer aggressiveness |
| topic | alcohol intake SNP interaction prostate cancer |
| url | https://www.mdpi.com/2077-0383/10/3/553 |
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