The Many Ways to Deal with STING
The stimulator of interferon genes (STING) is an adaptor protein involved in the activation of IFN-β and many other genes associated with the immune response activation in vertebrates. STING induction has gained attention from different angles such as the potential to trigger an early immune respons...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/10/9032 |
| _version_ | 1797599762882494464 |
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| author | Claire Coderch Javier Arranz-Herrero Estanislao Nistal-Villan Beatriz de Pascual-Teresa Sergio Rius-Rocabert |
| author_facet | Claire Coderch Javier Arranz-Herrero Estanislao Nistal-Villan Beatriz de Pascual-Teresa Sergio Rius-Rocabert |
| author_sort | Claire Coderch |
| collection | DOAJ |
| description | The stimulator of interferon genes (STING) is an adaptor protein involved in the activation of IFN-β and many other genes associated with the immune response activation in vertebrates. STING induction has gained attention from different angles such as the potential to trigger an early immune response against different signs of infection and cell damage, or to be used as an adjuvant in cancer immune treatments. Pharmacological control of aberrant STING activation can be used to mitigate the pathology of some autoimmune diseases. The STING structure has a well-defined ligand binding site that can harbor natural ligands such as specific purine cyclic di-nucleotides (CDN). In addition to a canonical stimulation by CDNs, other non-canonical stimuli have also been described, whose exact mechanism has not been well defined. Understanding the molecular insights underlying the activation of STING is important to realize the different angles that need to be considered when designing new STING-binding molecules as therapeutic drugs since STING acts as a versatile platform for immune modulators. This review analyzes the different determinants of STING regulation from the structural, molecular, and cell biology points of view. |
| first_indexed | 2024-03-11T03:38:54Z |
| format | Article |
| id | doaj.art-bf27122d3e5547e7b47c79a92bee594a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:38:54Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-bf27122d3e5547e7b47c79a92bee594a2023-11-18T01:46:13ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012410903210.3390/ijms24109032The Many Ways to Deal with STINGClaire Coderch0Javier Arranz-Herrero1Estanislao Nistal-Villan2Beatriz de Pascual-Teresa3Sergio Rius-Rocabert4Departamento de Química y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28668 Boadilla del Monte, SpainTransplant Immunology Unit, National Center of Microbiology, Instituto de Salud Carlos III, 28220 Majadahonda, SpainDepartamento CC, Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28668 Boadilla del Monte, SpainDepartamento de Química y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28668 Boadilla del Monte, SpainDepartamento CC, Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28668 Boadilla del Monte, SpainThe stimulator of interferon genes (STING) is an adaptor protein involved in the activation of IFN-β and many other genes associated with the immune response activation in vertebrates. STING induction has gained attention from different angles such as the potential to trigger an early immune response against different signs of infection and cell damage, or to be used as an adjuvant in cancer immune treatments. Pharmacological control of aberrant STING activation can be used to mitigate the pathology of some autoimmune diseases. The STING structure has a well-defined ligand binding site that can harbor natural ligands such as specific purine cyclic di-nucleotides (CDN). In addition to a canonical stimulation by CDNs, other non-canonical stimuli have also been described, whose exact mechanism has not been well defined. Understanding the molecular insights underlying the activation of STING is important to realize the different angles that need to be considered when designing new STING-binding molecules as therapeutic drugs since STING acts as a versatile platform for immune modulators. This review analyzes the different determinants of STING regulation from the structural, molecular, and cell biology points of view.https://www.mdpi.com/1422-0067/24/10/9032STINGIFNantiviral response |
| spellingShingle | Claire Coderch Javier Arranz-Herrero Estanislao Nistal-Villan Beatriz de Pascual-Teresa Sergio Rius-Rocabert The Many Ways to Deal with STING International Journal of Molecular Sciences STING IFN antiviral response |
| title | The Many Ways to Deal with STING |
| title_full | The Many Ways to Deal with STING |
| title_fullStr | The Many Ways to Deal with STING |
| title_full_unstemmed | The Many Ways to Deal with STING |
| title_short | The Many Ways to Deal with STING |
| title_sort | many ways to deal with sting |
| topic | STING IFN antiviral response |
| url | https://www.mdpi.com/1422-0067/24/10/9032 |
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