The effect of levodopa on bilateral coordination and gait asymmetry in Parkinson’s disease using inertial sensor
Abstract This study aimed to evaluate the effect of levodopa on the phase coordination index (PCI) and gait asymmetry (GA) of patients with Parkinson’s disease (PD) and to investigate correlations between the severity of motor symptoms and gait parameters measured using an inertial sensor. Twenty-si...
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| Format: | Article |
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Nature Portfolio
2021-05-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-021-00186-7 |
| _version_ | 1797428757670133760 |
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| author | Minji Son Seung Hwan Han Chul Hyoung Lyoo Joo Ae Lim Jeanhong Jeon Kee-Bum Hong Hoon Park |
| author_facet | Minji Son Seung Hwan Han Chul Hyoung Lyoo Joo Ae Lim Jeanhong Jeon Kee-Bum Hong Hoon Park |
| author_sort | Minji Son |
| collection | DOAJ |
| description | Abstract This study aimed to evaluate the effect of levodopa on the phase coordination index (PCI) and gait asymmetry (GA) of patients with Parkinson’s disease (PD) and to investigate correlations between the severity of motor symptoms and gait parameters measured using an inertial sensor. Twenty-six patients with mild-to-moderate-stage PD who were taking levodopa participated in this study. The Unified Parkinson’s Disease Rating Scale part III (UPDRS III) was used to assess the severity of motor impairment. The Postural Instability and Gait Difficulty (PIGD) subscore was calculated from UPDRS III. Patients were assessed while walking a 20-m corridor in both “OFF” and “ON” levodopa medication states, and gait analysis was performed using inertial sensors. We investigated the changes in gait parameters after taking levodopa and the correlations between UPDRS III, PIGD, and gait parameters. There was a significant improvement in PCI after taking levodopa. No significant effect of levodopa on GA was found. In “OFF” state, PCI and GA were not correlated with UPDRS III and PIGD. However, in “ON” state, PCI was the only gait parameter correlating with UPDRS III, and it was also highly correlated with PIGD compared to other gait parameters. Significant improvement in bilateral-phase coordination was identified in patients with PD after taking levodopa, without significant change in gait symmetricity. Considering the high correlation with UDPRS III and PIGD in “ON” states, PCI may be a useful and quantitative parameter to measure the severity of motor symptoms in PD patients who are on medication. |
| first_indexed | 2024-03-09T09:03:29Z |
| format | Article |
| id | doaj.art-bf2964903bd4447c831df624fb6c0bfc |
| institution | Directory Open Access Journal |
| issn | 2373-8057 |
| language | English |
| last_indexed | 2024-03-09T09:03:29Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj.art-bf2964903bd4447c831df624fb6c0bfc2023-12-02T11:13:15ZengNature Portfolionpj Parkinson's Disease2373-80572021-05-01711710.1038/s41531-021-00186-7The effect of levodopa on bilateral coordination and gait asymmetry in Parkinson’s disease using inertial sensorMinji Son0Seung Hwan Han1Chul Hyoung Lyoo2Joo Ae Lim3Jeanhong Jeon4Kee-Bum Hong5Hoon Park6Deepmotion analytics Co., Ltd. Research InstituteDepartment of Orthopaedic Surgery, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Orthopaedic Surgery, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Orthopaedic Surgery, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Orthopaedic Surgery, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Orthopaedic Surgery, Gangnam Severance Hospital, Yonsei University College of MedicineAbstract This study aimed to evaluate the effect of levodopa on the phase coordination index (PCI) and gait asymmetry (GA) of patients with Parkinson’s disease (PD) and to investigate correlations between the severity of motor symptoms and gait parameters measured using an inertial sensor. Twenty-six patients with mild-to-moderate-stage PD who were taking levodopa participated in this study. The Unified Parkinson’s Disease Rating Scale part III (UPDRS III) was used to assess the severity of motor impairment. The Postural Instability and Gait Difficulty (PIGD) subscore was calculated from UPDRS III. Patients were assessed while walking a 20-m corridor in both “OFF” and “ON” levodopa medication states, and gait analysis was performed using inertial sensors. We investigated the changes in gait parameters after taking levodopa and the correlations between UPDRS III, PIGD, and gait parameters. There was a significant improvement in PCI after taking levodopa. No significant effect of levodopa on GA was found. In “OFF” state, PCI and GA were not correlated with UPDRS III and PIGD. However, in “ON” state, PCI was the only gait parameter correlating with UPDRS III, and it was also highly correlated with PIGD compared to other gait parameters. Significant improvement in bilateral-phase coordination was identified in patients with PD after taking levodopa, without significant change in gait symmetricity. Considering the high correlation with UDPRS III and PIGD in “ON” states, PCI may be a useful and quantitative parameter to measure the severity of motor symptoms in PD patients who are on medication.https://doi.org/10.1038/s41531-021-00186-7 |
| spellingShingle | Minji Son Seung Hwan Han Chul Hyoung Lyoo Joo Ae Lim Jeanhong Jeon Kee-Bum Hong Hoon Park The effect of levodopa on bilateral coordination and gait asymmetry in Parkinson’s disease using inertial sensor npj Parkinson's Disease |
| title | The effect of levodopa on bilateral coordination and gait asymmetry in Parkinson’s disease using inertial sensor |
| title_full | The effect of levodopa on bilateral coordination and gait asymmetry in Parkinson’s disease using inertial sensor |
| title_fullStr | The effect of levodopa on bilateral coordination and gait asymmetry in Parkinson’s disease using inertial sensor |
| title_full_unstemmed | The effect of levodopa on bilateral coordination and gait asymmetry in Parkinson’s disease using inertial sensor |
| title_short | The effect of levodopa on bilateral coordination and gait asymmetry in Parkinson’s disease using inertial sensor |
| title_sort | effect of levodopa on bilateral coordination and gait asymmetry in parkinson s disease using inertial sensor |
| url | https://doi.org/10.1038/s41531-021-00186-7 |
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