Baseline treatments and metabolic control of 288,913 type 2 diabetes patients in a 10-year retrospective cohort in Malaysia
Abstract Diabetes is one of the quickest-growing global health emergencies of the twenty-first century, and data-driven care can improve the quality of diabetes management. We aimed to describe the formation of a 10-year retrospective open cohort of type 2 diabetes patients in Malaysia. We also desc...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-44564-y |
| _version_ | 1797452971416485888 |
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| author | Kim Sui Wan Feisul Mustapha Arunah Chandran Shubash Shander Ganapathy Nurhaliza Zakariah Sivarajan Ramasamy Gunenthira Rao Subbarao Muhammad Fadhli Mohd Yusoff |
| author_facet | Kim Sui Wan Feisul Mustapha Arunah Chandran Shubash Shander Ganapathy Nurhaliza Zakariah Sivarajan Ramasamy Gunenthira Rao Subbarao Muhammad Fadhli Mohd Yusoff |
| author_sort | Kim Sui Wan |
| collection | DOAJ |
| description | Abstract Diabetes is one of the quickest-growing global health emergencies of the twenty-first century, and data-driven care can improve the quality of diabetes management. We aimed to describe the formation of a 10-year retrospective open cohort of type 2 diabetes patients in Malaysia. We also described the baseline treatment profiles and HbA1c, blood pressure, and lipid control to assess the quality of diabetes care. We used 10 years of cross-sectional audit datasets from the National Diabetes Registry and merged 288,913 patients with the same identifying information into a 10-year open cohort dataset. Treatment targets for HbA1c, blood pressure, LDL-cholesterol, HDL-cholesterol, and triglycerides were based on Malaysian clinical practice guidelines. IBM SPSS Statistics version 23.0 was used, and frequencies and percentages with 95% confidence intervals were reported. In total, 288,913 patients were included, with 62.3% women and 54.1% younger adults. The commonest diabetes treatment modality was oral hypoglycaemic agents (75.9%). Meanwhile, 19.3% of patients had ≥ 3 antihypertensive agents, and 71.2% were on lipid-lowering drugs. Metformin (86.1%), angiotensin-converting enzyme inhibitors (49.6%), and statins (69.2%) were the most prescribed antidiabetic, antihypertensive, and lipid-lowering medications, respectively. The mean HbA1c was 7.96 ± 2.11, and 31.2% had HbA1c > 8.5%. Only 35.8% and 35.2% attained blood pressure < 140/80 mmHg and LDL-cholesterol < 2.6 mmol/L, respectively. About 57.5% and 52.9% achieved their respective triglyceride and HDL-cholesterol goals. In conclusion, data integration is a feasible method in this diabetes registry. HbA1c, blood pressure, and lipids are not optimally controlled, and these findings can be capitalized as a guideline by clinicians, programme managers, and health policymakers to improve the quality of diabetes care and prevent long-term complications in Malaysia. |
| first_indexed | 2024-03-09T15:15:55Z |
| format | Article |
| id | doaj.art-bf29d6a795fb4257816991b10ce44131 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:15:55Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-bf29d6a795fb4257816991b10ce441312023-11-26T13:04:52ZengNature PortfolioScientific Reports2045-23222023-10-0113111010.1038/s41598-023-44564-yBaseline treatments and metabolic control of 288,913 type 2 diabetes patients in a 10-year retrospective cohort in MalaysiaKim Sui Wan0Feisul Mustapha1Arunah Chandran2Shubash Shander Ganapathy3Nurhaliza Zakariah4Sivarajan Ramasamy5Gunenthira Rao Subbarao6Muhammad Fadhli Mohd Yusoff7Institute for Public Health, National Institutes of Health, Ministry of Health MalaysiaDisease Control Division, Ministry of Health Malaysia, Federal Government Administration CentreDisease Control Division, Ministry of Health Malaysia, Federal Government Administration CentreInstitute for Public Health, National Institutes of Health, Ministry of Health MalaysiaDisease Control Division, Ministry of Health Malaysia, Federal Government Administration CentreState Health Department of Negeri Sembilan, Ministry of Health MalaysiaMedical Development Division, Ministry of Health Malaysia, Federal Government Administration CentreInstitute for Public Health, National Institutes of Health, Ministry of Health MalaysiaAbstract Diabetes is one of the quickest-growing global health emergencies of the twenty-first century, and data-driven care can improve the quality of diabetes management. We aimed to describe the formation of a 10-year retrospective open cohort of type 2 diabetes patients in Malaysia. We also described the baseline treatment profiles and HbA1c, blood pressure, and lipid control to assess the quality of diabetes care. We used 10 years of cross-sectional audit datasets from the National Diabetes Registry and merged 288,913 patients with the same identifying information into a 10-year open cohort dataset. Treatment targets for HbA1c, blood pressure, LDL-cholesterol, HDL-cholesterol, and triglycerides were based on Malaysian clinical practice guidelines. IBM SPSS Statistics version 23.0 was used, and frequencies and percentages with 95% confidence intervals were reported. In total, 288,913 patients were included, with 62.3% women and 54.1% younger adults. The commonest diabetes treatment modality was oral hypoglycaemic agents (75.9%). Meanwhile, 19.3% of patients had ≥ 3 antihypertensive agents, and 71.2% were on lipid-lowering drugs. Metformin (86.1%), angiotensin-converting enzyme inhibitors (49.6%), and statins (69.2%) were the most prescribed antidiabetic, antihypertensive, and lipid-lowering medications, respectively. The mean HbA1c was 7.96 ± 2.11, and 31.2% had HbA1c > 8.5%. Only 35.8% and 35.2% attained blood pressure < 140/80 mmHg and LDL-cholesterol < 2.6 mmol/L, respectively. About 57.5% and 52.9% achieved their respective triglyceride and HDL-cholesterol goals. In conclusion, data integration is a feasible method in this diabetes registry. HbA1c, blood pressure, and lipids are not optimally controlled, and these findings can be capitalized as a guideline by clinicians, programme managers, and health policymakers to improve the quality of diabetes care and prevent long-term complications in Malaysia.https://doi.org/10.1038/s41598-023-44564-y |
| spellingShingle | Kim Sui Wan Feisul Mustapha Arunah Chandran Shubash Shander Ganapathy Nurhaliza Zakariah Sivarajan Ramasamy Gunenthira Rao Subbarao Muhammad Fadhli Mohd Yusoff Baseline treatments and metabolic control of 288,913 type 2 diabetes patients in a 10-year retrospective cohort in Malaysia Scientific Reports |
| title | Baseline treatments and metabolic control of 288,913 type 2 diabetes patients in a 10-year retrospective cohort in Malaysia |
| title_full | Baseline treatments and metabolic control of 288,913 type 2 diabetes patients in a 10-year retrospective cohort in Malaysia |
| title_fullStr | Baseline treatments and metabolic control of 288,913 type 2 diabetes patients in a 10-year retrospective cohort in Malaysia |
| title_full_unstemmed | Baseline treatments and metabolic control of 288,913 type 2 diabetes patients in a 10-year retrospective cohort in Malaysia |
| title_short | Baseline treatments and metabolic control of 288,913 type 2 diabetes patients in a 10-year retrospective cohort in Malaysia |
| title_sort | baseline treatments and metabolic control of 288 913 type 2 diabetes patients in a 10 year retrospective cohort in malaysia |
| url | https://doi.org/10.1038/s41598-023-44564-y |
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