Gated Calcium Ion Channel and Mutation Mechanisms in Multidrug-Resistant Tuberculosis
A wide spectrum of Gram-positive/Gram-negative bacteria has been found resistant to a wide spectrum of antibiotics in the United States of America during the past decade. Drug-resistant tuberculosis is not yet a major threat in North/South America, Europe, and the Middle East. However, the migration...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/11/9670 |
| _version_ | 1797597347595681792 |
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| author | John A. D’Elia Larry A. Weinrauch |
| author_facet | John A. D’Elia Larry A. Weinrauch |
| author_sort | John A. D’Elia |
| collection | DOAJ |
| description | A wide spectrum of Gram-positive/Gram-negative bacteria has been found resistant to a wide spectrum of antibiotics in the United States of America during the past decade. Drug-resistant tuberculosis is not yet a major threat in North/South America, Europe, and the Middle East. However, the migration of populations in times of drought, famine, and hostilities may increase the global reach of this ancient pathogen. Given an increased spread from China and India to African countries, drug-resistant <i>Mycobacterium tuberculosis</i> has become an emerging topic of concern for Europe and North America. Due to the dangers associated with the spread of pathogens among different populations, the World Health Organization continues to expand healthcare advisories for therapeutic approaches for both stationary and migrating populations. As much of the literature focuses on endemic to pandemic viruses, we remain concerned that other treatable communicable diseases may be ignored. One such disease is multidrug-resistant tuberculosis. We focus on molecular mechanisms that this pathogen relies upon for the development of multidrug resistance via gene mutation and the evolutionary development of new enzyme and calcium channels. |
| first_indexed | 2024-03-11T03:04:57Z |
| format | Article |
| id | doaj.art-bf2afca2c8704bdd8d5f5931cc50ad0b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:04:57Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-bf2afca2c8704bdd8d5f5931cc50ad0b2023-11-18T08:02:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-012411967010.3390/ijms24119670Gated Calcium Ion Channel and Mutation Mechanisms in Multidrug-Resistant TuberculosisJohn A. D’Elia0Larry A. Weinrauch1Kidney/Hypertension Section, E P Joslin Research Laboratory, Joslin Diabetes Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USAKidney/Hypertension Section, E P Joslin Research Laboratory, Joslin Diabetes Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USAA wide spectrum of Gram-positive/Gram-negative bacteria has been found resistant to a wide spectrum of antibiotics in the United States of America during the past decade. Drug-resistant tuberculosis is not yet a major threat in North/South America, Europe, and the Middle East. However, the migration of populations in times of drought, famine, and hostilities may increase the global reach of this ancient pathogen. Given an increased spread from China and India to African countries, drug-resistant <i>Mycobacterium tuberculosis</i> has become an emerging topic of concern for Europe and North America. Due to the dangers associated with the spread of pathogens among different populations, the World Health Organization continues to expand healthcare advisories for therapeutic approaches for both stationary and migrating populations. As much of the literature focuses on endemic to pandemic viruses, we remain concerned that other treatable communicable diseases may be ignored. One such disease is multidrug-resistant tuberculosis. We focus on molecular mechanisms that this pathogen relies upon for the development of multidrug resistance via gene mutation and the evolutionary development of new enzyme and calcium channels.https://www.mdpi.com/1422-0067/24/11/9670antibiotic resistancecalcium ion channelsextrusion of antibioticsinnate immunityadaptive immunity<i>Mycobacterium tuberculosis</i> |
| spellingShingle | John A. D’Elia Larry A. Weinrauch Gated Calcium Ion Channel and Mutation Mechanisms in Multidrug-Resistant Tuberculosis International Journal of Molecular Sciences antibiotic resistance calcium ion channels extrusion of antibiotics innate immunity adaptive immunity <i>Mycobacterium tuberculosis</i> |
| title | Gated Calcium Ion Channel and Mutation Mechanisms in Multidrug-Resistant Tuberculosis |
| title_full | Gated Calcium Ion Channel and Mutation Mechanisms in Multidrug-Resistant Tuberculosis |
| title_fullStr | Gated Calcium Ion Channel and Mutation Mechanisms in Multidrug-Resistant Tuberculosis |
| title_full_unstemmed | Gated Calcium Ion Channel and Mutation Mechanisms in Multidrug-Resistant Tuberculosis |
| title_short | Gated Calcium Ion Channel and Mutation Mechanisms in Multidrug-Resistant Tuberculosis |
| title_sort | gated calcium ion channel and mutation mechanisms in multidrug resistant tuberculosis |
| topic | antibiotic resistance calcium ion channels extrusion of antibiotics innate immunity adaptive immunity <i>Mycobacterium tuberculosis</i> |
| url | https://www.mdpi.com/1422-0067/24/11/9670 |
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