Mitochondrial Oxidative Stress Promotes Cardiac Remodeling in Myocardial Infarction through the Activation of Endoplasmic Reticulum Stress

Mitochondrial Oxidative Stress Promotes Cardiac Remodeling in Myocardial Infarction through the Activation of Endoplasmic Reticulum Stress

We have evaluated cardiac function and fibrosis in infarcted male Wistar rats treated with MitoQ (50 mg/kg/day) or vehicle for 4 weeks. A cohort of patients admitted with a first episode of acute MI were also analyzed with cardiac magnetic resonance and T1 mapping during admission and at a 12-month...

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Bibliographic Details
Main Authors: Francisco V. Souza-Neto, Fabian Islas, Sara Jiménez-González, María Luaces, Bunty Ramchandani, Ana Romero-Miranda, Beatriz Delgado-Valero, Elena Roldan-Molina, Melchor Saiz-Pardo, Mª Ángeles Cerón-Nieto, Luis Ortega-Medina, Ernesto Martínez-Martínez, Victoria Cachofeiro
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Antioxidants
Subjects:
cardiac fibrosis
mitochondrial oxidative stress
endoplasmic reticulum stress
myocardial ischemia
Online Access:https://www.mdpi.com/2076-3921/11/7/1232

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https://www.mdpi.com/2076-3921/11/7/1232

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