Ecological lipidology
Dietary lipids (DLs), particularly sterols and fatty acids, are precursors for endogenous lipids that, unusually for macronutrients, shape cellular and organismal function long after ingestion. These functions – cell membrane structure, intracellular signalling, and hormonal activity – vary with the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2022-09-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/79288 |
| _version_ | 1811181864733376512 |
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| author | Laura Christin Trautenberg Marko Brankatschk Andrej Shevchenko Stuart Wigby Klaus Reinhardt |
| author_facet | Laura Christin Trautenberg Marko Brankatschk Andrej Shevchenko Stuart Wigby Klaus Reinhardt |
| author_sort | Laura Christin Trautenberg |
| collection | DOAJ |
| description | Dietary lipids (DLs), particularly sterols and fatty acids, are precursors for endogenous lipids that, unusually for macronutrients, shape cellular and organismal function long after ingestion. These functions – cell membrane structure, intracellular signalling, and hormonal activity – vary with the identity of DLs, and scale up to influence health, survival, and reproductive fitness, thereby affecting evolutionary change. Our Ecological Lipidology approach integrates biochemical mechanisms and molecular cell biology into evolution and nutritional ecology. It exposes our need to understand environmental impacts on lipidomes, the lipid specificity of cell functions, and predicts the evolution of lipid-based diet choices. Broad interdisciplinary implications of Ecological Lipidology include food web alterations, species responses to environmental change, as well as sex differences and lifestyle impacts on human nutrition, and opportunities for DL-based therapies. |
| first_indexed | 2024-04-11T09:23:57Z |
| format | Article |
| id | doaj.art-bf2be8146db847a4b87f5bcf56d29bdd |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:23:57Z |
| publishDate | 2022-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-bf2be8146db847a4b87f5bcf56d29bdd2022-12-22T04:32:06ZengeLife Sciences Publications LtdeLife2050-084X2022-09-011110.7554/eLife.79288Ecological lipidologyLaura Christin Trautenberg0https://orcid.org/0000-0002-3812-3773Marko Brankatschk1https://orcid.org/0000-0001-5274-4552Andrej Shevchenko2https://orcid.org/0000-0002-5079-1109Stuart Wigby3https://orcid.org/0000-0002-2260-2948Klaus Reinhardt4https://orcid.org/0000-0003-4205-2370Biotechnology Center (BIOTEC), Technische Universität Dresden, Dresden, GermanyBiotechnology Center (BIOTEC), Technische Universität Dresden, Dresden, GermanyMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, GermanyApplied Zoology, Technische Universität Dresden, Dresden, Germany; Department of Evolution, Ecology and Behaviour, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United KingdomApplied Zoology, Technische Universität Dresden, Dresden, GermanyDietary lipids (DLs), particularly sterols and fatty acids, are precursors for endogenous lipids that, unusually for macronutrients, shape cellular and organismal function long after ingestion. These functions – cell membrane structure, intracellular signalling, and hormonal activity – vary with the identity of DLs, and scale up to influence health, survival, and reproductive fitness, thereby affecting evolutionary change. Our Ecological Lipidology approach integrates biochemical mechanisms and molecular cell biology into evolution and nutritional ecology. It exposes our need to understand environmental impacts on lipidomes, the lipid specificity of cell functions, and predicts the evolution of lipid-based diet choices. Broad interdisciplinary implications of Ecological Lipidology include food web alterations, species responses to environmental change, as well as sex differences and lifestyle impacts on human nutrition, and opportunities for DL-based therapies.https://elifesciences.org/articles/79288diet choicefatty acidsfitnessfood webmembranesterols |
| spellingShingle | Laura Christin Trautenberg Marko Brankatschk Andrej Shevchenko Stuart Wigby Klaus Reinhardt Ecological lipidology eLife diet choice fatty acids fitness food web membrane sterols |
| title | Ecological lipidology |
| title_full | Ecological lipidology |
| title_fullStr | Ecological lipidology |
| title_full_unstemmed | Ecological lipidology |
| title_short | Ecological lipidology |
| title_sort | ecological lipidology |
| topic | diet choice fatty acids fitness food web membrane sterols |
| url | https://elifesciences.org/articles/79288 |
| work_keys_str_mv | AT laurachristintrautenberg ecologicallipidology AT markobrankatschk ecologicallipidology AT andrejshevchenko ecologicallipidology AT stuartwigby ecologicallipidology AT klausreinhardt ecologicallipidology |