Prevalence of Antibodies to Hepatitis B Virus Antigens and Occult Hepatitis B Virus Infection in Blood Donors
Background: Occult hepatitis B virus (HBV) is the presence of HBV DNA in liver tissue and/or in serum in the absence of detectable hepatitis B surface antigen (HBsAg). It is a world-wide entity that is considered as a potential risk for transmission of HBV infection. Aim: This study was aimed to de...
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| Format: | Article |
| Language: | English |
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College of medicine/ University of Diyala
2019-11-01
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| Series: | Diyala Journal of Medicine |
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| Online Access: | http://djm.uodiyala.edu.iq/index.php/djm/article/view/429 |
| _version_ | 1797454787786047488 |
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| author | Abdulrazak SH Hasan |
| author_facet | Abdulrazak SH Hasan |
| author_sort | Abdulrazak SH Hasan |
| collection | DOAJ |
| description | Background: Occult hepatitis B virus (HBV) is the presence of HBV DNA in liver tissue and/or in serum in the absence of detectable hepatitis B surface antigen (HBsAg). It is a world-wide entity that is considered as a potential risk for transmission of HBV infection.
Aim: This study was aimed to determine the rate of occult HBV infection among unpaid blood donors in Diyala province-Iraq.
Subjects and methods: This study was conducted for the period from 1st. May 2011 to 1st. April 2012. A total of 186 unpaid blood donors were chosen by simple random selection from those attending the Central Blood Bank in the Public Health Laboratory in Diyala province. 171 (91.9%) were male and 15 (8.1%) were female. The age range was 19-60 years. Sera of blood donors were subjected for HBsAg screening test, anti-HBs antibody, anti-HBc IgM antibody by enzyme linked immunosorbant assay (ELISA), as well as detection of HBV DNA by conventional polymerase chain reaction (PCR) technique. Data were statistically analyzed.
Results: The positivity rate of HBsAg, anti-HBc IgM and HBV DNA were 4.3%, 3.2% and 8.1%. Among the HBsAg negative blood donors, the HBc IgM positivity rate were 3.4% and the HBV DNA was detected in 3.9% (occult HBV).
Conclusion: The relatively high rate of occult hepatitis B viral infection among blood donors may be responsible, at least in part, for the perpetuation of the infection in the community. |
| first_indexed | 2024-03-09T15:43:10Z |
| format | Article |
| id | doaj.art-bf2d358f33d9440b8a2968f94b34ec36 |
| institution | Directory Open Access Journal |
| issn | 2219-9764 2617-8982 |
| language | English |
| last_indexed | 2024-03-09T15:43:10Z |
| publishDate | 2019-11-01 |
| publisher | College of medicine/ University of Diyala |
| record_format | Article |
| series | Diyala Journal of Medicine |
| spelling | doaj.art-bf2d358f33d9440b8a2968f94b34ec362023-11-24T23:23:33ZengCollege of medicine/ University of DiyalaDiyala Journal of Medicine2219-97642617-89822019-11-0131Prevalence of Antibodies to Hepatitis B Virus Antigens and Occult Hepatitis B Virus Infection in Blood DonorsAbdulrazak SH Hasan Background: Occult hepatitis B virus (HBV) is the presence of HBV DNA in liver tissue and/or in serum in the absence of detectable hepatitis B surface antigen (HBsAg). It is a world-wide entity that is considered as a potential risk for transmission of HBV infection. Aim: This study was aimed to determine the rate of occult HBV infection among unpaid blood donors in Diyala province-Iraq. Subjects and methods: This study was conducted for the period from 1st. May 2011 to 1st. April 2012. A total of 186 unpaid blood donors were chosen by simple random selection from those attending the Central Blood Bank in the Public Health Laboratory in Diyala province. 171 (91.9%) were male and 15 (8.1%) were female. The age range was 19-60 years. Sera of blood donors were subjected for HBsAg screening test, anti-HBs antibody, anti-HBc IgM antibody by enzyme linked immunosorbant assay (ELISA), as well as detection of HBV DNA by conventional polymerase chain reaction (PCR) technique. Data were statistically analyzed. Results: The positivity rate of HBsAg, anti-HBc IgM and HBV DNA were 4.3%, 3.2% and 8.1%. Among the HBsAg negative blood donors, the HBc IgM positivity rate were 3.4% and the HBV DNA was detected in 3.9% (occult HBV). Conclusion: The relatively high rate of occult hepatitis B viral infection among blood donors may be responsible, at least in part, for the perpetuation of the infection in the community.http://djm.uodiyala.edu.iq/index.php/djm/article/view/429Occult HBV, Anti-HBc IgM, HBV DNA, blood donors |
| spellingShingle | Abdulrazak SH Hasan Prevalence of Antibodies to Hepatitis B Virus Antigens and Occult Hepatitis B Virus Infection in Blood Donors Diyala Journal of Medicine Occult HBV, Anti-HBc IgM, HBV DNA, blood donors |
| title | Prevalence of Antibodies to Hepatitis B Virus Antigens and Occult Hepatitis B Virus Infection in Blood Donors |
| title_full | Prevalence of Antibodies to Hepatitis B Virus Antigens and Occult Hepatitis B Virus Infection in Blood Donors |
| title_fullStr | Prevalence of Antibodies to Hepatitis B Virus Antigens and Occult Hepatitis B Virus Infection in Blood Donors |
| title_full_unstemmed | Prevalence of Antibodies to Hepatitis B Virus Antigens and Occult Hepatitis B Virus Infection in Blood Donors |
| title_short | Prevalence of Antibodies to Hepatitis B Virus Antigens and Occult Hepatitis B Virus Infection in Blood Donors |
| title_sort | prevalence of antibodies to hepatitis b virus antigens and occult hepatitis b virus infection in blood donors |
| topic | Occult HBV, Anti-HBc IgM, HBV DNA, blood donors |
| url | http://djm.uodiyala.edu.iq/index.php/djm/article/view/429 |
| work_keys_str_mv | AT abdulrazakshhasan prevalenceofantibodiestohepatitisbvirusantigensandocculthepatitisbvirusinfectioninblooddonors |