Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans

Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans

To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex. Polymerase basic 2–482R, polymerase basic 2–588V, and polymerase acidic–497R individually or additively enhanced virus polymerase activity, ind...

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Bibliographic Details
Main Authors: Seiya Yamayoshi, Maki Kiso, Atsuhiro Yasuhara, Mutsumi Ito, Yuelong Shu, Yoshihiro Kawaoka
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2018-04-01
Series:Emerging Infectious Diseases
Subjects:
Highly pathogenic
H7N9
PB2
PA
enhanced polymerase activity
influenza
Online Access:https://wwwnc.cdc.gov/eid/article/24/4/17-1509_article

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