Right and Left Colorectal Cancer: Differences in Post-Surgical-Care Outcomes and Survival in Elderly Patients
(1) There is evidence of the embryological, anatomical, histological, genetic and immunological differences between right colon cancer (RCC) and left colon cancer (LCC). This research has the general objective of studying the differences in outcome between RCC and LCC. (2) A longitudinal analytical...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/11/2647 |
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| author | Irene Mirón Fernández Santiago Mera Velasco Jesús Damián Turiño Luque Iván González Poveda Manuel Ruiz López Julio Santoyo Santoyo |
| author_facet | Irene Mirón Fernández Santiago Mera Velasco Jesús Damián Turiño Luque Iván González Poveda Manuel Ruiz López Julio Santoyo Santoyo |
| author_sort | Irene Mirón Fernández |
| collection | DOAJ |
| description | (1) There is evidence of the embryological, anatomical, histological, genetic and immunological differences between right colon cancer (RCC) and left colon cancer (LCC). This research has the general objective of studying the differences in outcome between RCC and LCC. (2) A longitudinal analytical study with prospective follow-up of the case–control type was conducted from 1 January 2010 to 31 December 2017 including 398 patients with 1:1 matching, depending on the location of the tumor. Inclusion criteria: programmed colectomies, 15 cm above the anal margin, adults and R0 surgery. (3) Precisely 6.8% of the exitus occurred in the first 6 months of the intervention. At 6 months, patients with LCC presented a mean survival of 7 months higher than RCC (<i>p</i> = 0.028). In the first stages, it can be observed that most of the exitus are for patients with RCC (stage I <i>p</i> = 0.021, stage II <i>p</i> = 0.014). In the last stages, the distribution of the deaths does not show differences between locations (stage III <i>p</i> = 0.683, stage IV <i>p</i> = 0.898). (4) The results show that RCC and LCC are significantly different in terms of evolution, progression, complications and survival. Patients with RCC have a worse prognosis, even in the early stages of the disease, due to more advanced N stages, larger tumor size, more frequently poorly differentiated tumors and a greater positivity of lymphovascular invasion than LCC. |
| first_indexed | 2024-03-10T10:57:54Z |
| format | Article |
| id | doaj.art-bf311d84be3a4705aebd468b19c53803 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T10:57:54Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-bf311d84be3a4705aebd468b19c538032023-11-21T21:45:14ZengMDPI AGCancers2072-66942021-05-011311264710.3390/cancers13112647Right and Left Colorectal Cancer: Differences in Post-Surgical-Care Outcomes and Survival in Elderly PatientsIrene Mirón Fernández0Santiago Mera Velasco1Jesús Damián Turiño Luque2Iván González Poveda3Manuel Ruiz López4Julio Santoyo Santoyo5Department of General, Digestive and Transplant Surgery, Malaga Regional University Hospital, Malaga’s University, 29010 Málaga, SpainColorectal Unit, Department of General, Digestive and Transplant Surgery, Malaga Regional University Hospital, 29010 Málaga, SpainDepartment of General, Digestive and Transplant Surgery, Malaga Regional University Hospital, Malaga’s University, 29010 Málaga, SpainColorectal Unit, Department of General, Digestive and Transplant Surgery, Malaga Regional University Hospital, 29010 Málaga, SpainColorectal Unit, Department of General, Digestive and Transplant Surgery, Malaga Regional University Hospital, 29010 Málaga, SpainDepartment of General, Digestive and Transplant Surgery, Malaga Regional University Hospital, Malaga’s University, 29010 Málaga, Spain(1) There is evidence of the embryological, anatomical, histological, genetic and immunological differences between right colon cancer (RCC) and left colon cancer (LCC). This research has the general objective of studying the differences in outcome between RCC and LCC. (2) A longitudinal analytical study with prospective follow-up of the case–control type was conducted from 1 January 2010 to 31 December 2017 including 398 patients with 1:1 matching, depending on the location of the tumor. Inclusion criteria: programmed colectomies, 15 cm above the anal margin, adults and R0 surgery. (3) Precisely 6.8% of the exitus occurred in the first 6 months of the intervention. At 6 months, patients with LCC presented a mean survival of 7 months higher than RCC (<i>p</i> = 0.028). In the first stages, it can be observed that most of the exitus are for patients with RCC (stage I <i>p</i> = 0.021, stage II <i>p</i> = 0.014). In the last stages, the distribution of the deaths does not show differences between locations (stage III <i>p</i> = 0.683, stage IV <i>p</i> = 0.898). (4) The results show that RCC and LCC are significantly different in terms of evolution, progression, complications and survival. Patients with RCC have a worse prognosis, even in the early stages of the disease, due to more advanced N stages, larger tumor size, more frequently poorly differentiated tumors and a greater positivity of lymphovascular invasion than LCC.https://www.mdpi.com/2072-6694/13/11/2647cancercolonsurvivaldifferences |
| spellingShingle | Irene Mirón Fernández Santiago Mera Velasco Jesús Damián Turiño Luque Iván González Poveda Manuel Ruiz López Julio Santoyo Santoyo Right and Left Colorectal Cancer: Differences in Post-Surgical-Care Outcomes and Survival in Elderly Patients Cancers cancer colon survival differences |
| title | Right and Left Colorectal Cancer: Differences in Post-Surgical-Care Outcomes and Survival in Elderly Patients |
| title_full | Right and Left Colorectal Cancer: Differences in Post-Surgical-Care Outcomes and Survival in Elderly Patients |
| title_fullStr | Right and Left Colorectal Cancer: Differences in Post-Surgical-Care Outcomes and Survival in Elderly Patients |
| title_full_unstemmed | Right and Left Colorectal Cancer: Differences in Post-Surgical-Care Outcomes and Survival in Elderly Patients |
| title_short | Right and Left Colorectal Cancer: Differences in Post-Surgical-Care Outcomes and Survival in Elderly Patients |
| title_sort | right and left colorectal cancer differences in post surgical care outcomes and survival in elderly patients |
| topic | cancer colon survival differences |
| url | https://www.mdpi.com/2072-6694/13/11/2647 |
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