Opinion - Thyroid (dys)function in heart failure: is it a potential target for medical treatment?
Alessandro Pingitore, Giorgio IervasiInstitute of Clinical Physiology, CNR, Pisa, ItalyIntroductionCurrently, there is little doubt that activation of the neuroendocrine (NE) system is predominately responsible for the progressive decline of heart function in heart failure (HF). This is due to the c...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2005-07-01
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| Series: | Vascular Health and Risk Management |
| Online Access: | https://www.dovepress.com/opinion---thyroid-dysfunction-in-heart-failure-is-it-a-potential-targe-peer-reviewed-article-VHRM |
| _version_ | 1818944369823055872 |
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| author | Alessandro Pingitore Giorgio Iervasi |
| author_facet | Alessandro Pingitore Giorgio Iervasi |
| author_sort | Alessandro Pingitore |
| collection | DOAJ |
| description | Alessandro Pingitore, Giorgio IervasiInstitute of Clinical Physiology, CNR, Pisa, ItalyIntroductionCurrently, there is little doubt that activation of the neuroendocrine (NE) system is predominately responsible for the progressive decline of heart function in heart failure (HF). This is due to the complex action of neurotransmitters, hormonal factors, and/or immunological pathways. Evidence that supports this point of view is the clear prognostic benefit and the reduction of HF progression by using NE-guided therapeutic approaches (SOLVD investigators 1992; Eichhorn and Bristow 1996; Packer et al 1996; Opie 2004; Solomon et al 2004). However, the fact that HF represents one of the major causes of morbidity and mortality in Western countries also suggests that the current portfolio of NE antagonists fails to completely explain and possibly counteract disease progression (Guyatt and Deveraux 2004). In this context, interest in the relationship between thyroid hormones (THs) and HF is increasingly gaining prominence. The chief reason for the latter is the emerging novel actions of THs on the cardiovascular system and, more specifically, the role of TH as a prognostic biomarker of cardiac disease as well as the potential benefit of TH administration in patients with HF. |
| first_indexed | 2024-12-20T07:42:08Z |
| format | Article |
| id | doaj.art-bf330b9a8853496db593db25eb25bd18 |
| institution | Directory Open Access Journal |
| issn | 1178-2048 |
| language | English |
| last_indexed | 2024-12-20T07:42:08Z |
| publishDate | 2005-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-bf330b9a8853496db593db25eb25bd182022-12-21T19:48:06ZengDove Medical PressVascular Health and Risk Management1178-20482005-07-01Volume 1971001366Opinion - Thyroid (dys)function in heart failure: is it a potential target for medical treatment?Alessandro PingitoreGiorgio IervasiAlessandro Pingitore, Giorgio IervasiInstitute of Clinical Physiology, CNR, Pisa, ItalyIntroductionCurrently, there is little doubt that activation of the neuroendocrine (NE) system is predominately responsible for the progressive decline of heart function in heart failure (HF). This is due to the complex action of neurotransmitters, hormonal factors, and/or immunological pathways. Evidence that supports this point of view is the clear prognostic benefit and the reduction of HF progression by using NE-guided therapeutic approaches (SOLVD investigators 1992; Eichhorn and Bristow 1996; Packer et al 1996; Opie 2004; Solomon et al 2004). However, the fact that HF represents one of the major causes of morbidity and mortality in Western countries also suggests that the current portfolio of NE antagonists fails to completely explain and possibly counteract disease progression (Guyatt and Deveraux 2004). In this context, interest in the relationship between thyroid hormones (THs) and HF is increasingly gaining prominence. The chief reason for the latter is the emerging novel actions of THs on the cardiovascular system and, more specifically, the role of TH as a prognostic biomarker of cardiac disease as well as the potential benefit of TH administration in patients with HF.https://www.dovepress.com/opinion---thyroid-dysfunction-in-heart-failure-is-it-a-potential-targe-peer-reviewed-article-VHRM |
| spellingShingle | Alessandro Pingitore Giorgio Iervasi Opinion - Thyroid (dys)function in heart failure: is it a potential target for medical treatment? Vascular Health and Risk Management |
| title | Opinion - Thyroid (dys)function in heart failure: is it a potential target for medical treatment? |
| title_full | Opinion - Thyroid (dys)function in heart failure: is it a potential target for medical treatment? |
| title_fullStr | Opinion - Thyroid (dys)function in heart failure: is it a potential target for medical treatment? |
| title_full_unstemmed | Opinion - Thyroid (dys)function in heart failure: is it a potential target for medical treatment? |
| title_short | Opinion - Thyroid (dys)function in heart failure: is it a potential target for medical treatment? |
| title_sort | opinion thyroid dys function in heart failure is it a potential target for medical treatment |
| url | https://www.dovepress.com/opinion---thyroid-dysfunction-in-heart-failure-is-it-a-potential-targe-peer-reviewed-article-VHRM |
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