Synthesis and characterization of capsaicin nanoparticles: An attempt to enhance its bioavailability and pharmacological actions
Herein, capsaicin nanoparticles (NPs) were prepared by two different methods, namely, evaporative precipitation of nanosuspension (EPN) and anti-solvent precipitation with a syringe pump (APSP). The nanoparticles of the necessary sizes were obtained after optimizing experimental parameters such as t...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2024-02-01
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| Series: | Green Processing and Synthesis |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/gps-2023-0206 |
| _version_ | 1797303204443062272 |
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| author | Sher Mujahid Hussain Ishtiaq Khan Farhat Ali Zahoor Muhammad Sher Wiaam Mujahid Khalil Muhammad Saqib Sulaiman Muhammad Ullah Riaz Naz Sumaira Ali Essam A. |
| author_facet | Sher Mujahid Hussain Ishtiaq Khan Farhat Ali Zahoor Muhammad Sher Wiaam Mujahid Khalil Muhammad Saqib Sulaiman Muhammad Ullah Riaz Naz Sumaira Ali Essam A. |
| author_sort | Sher Mujahid |
| collection | DOAJ |
| description | Herein, capsaicin nanoparticles (NPs) were prepared by two different methods, namely, evaporative precipitation of nanosuspension (EPN) and anti-solvent precipitation with a syringe pump (APSP). The nanoparticles of the necessary sizes were obtained after optimizing experimental parameters such as the solvent-to-anti-solvent ratio and stirring speed. They had spherical shapes and an average diameter of 171.29 ± 1.94 and 78.91 ± 0.54 nm when prepared using the EPN and APSP methods, respectively. Differential scanning calorimetry and an X-ray diffractometer showed that the capsaicin crystallinity decreased. FTIR results showed that the NPs were produced with their original configuration and did not result in the synthesis of any additional structures. The NP formulation had a desirable drug content. They surpassed the unprocessed drug in solubility and displayed the desired stability. Capsaicin NP cream showed many folds of enhanced analgesic, anti-inflammatory, and antimicrobial effects compared to unprocessed capsaicin. |
| first_indexed | 2024-03-07T23:49:28Z |
| format | Article |
| id | doaj.art-bf34ead3aeb840c892000ef417c515ca |
| institution | Directory Open Access Journal |
| issn | 2191-9550 |
| language | English |
| last_indexed | 2024-03-07T23:49:28Z |
| publishDate | 2024-02-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Green Processing and Synthesis |
| spelling | doaj.art-bf34ead3aeb840c892000ef417c515ca2024-02-19T09:01:50ZengDe GruyterGreen Processing and Synthesis2191-95502024-02-0113137687410.1515/gps-2023-0206Synthesis and characterization of capsaicin nanoparticles: An attempt to enhance its bioavailability and pharmacological actionsSher Mujahid0Hussain Ishtiaq1Khan Farhat Ali2Zahoor Muhammad3Sher Wiaam Mujahid4Khalil Muhammad Saqib5Sulaiman Muhammad6Ullah Riaz7Naz Sumaira8Ali Essam A.9Department of Pharmacy, Abbottabad University of Science and Technology, Abbottabad, PakistanDepartment of Pharmacy, Abbottabad University of Science and Technology, Abbottabad, PakistanDepartment of Pharmacy, Shaheed Benazir Bhutto University Sheringal, Dir Upper, PakistanDepartment of Biochemistry, University of Malakand, Chakdara, Lower Dir, Khyber Pakhtunkhwa, 18000, PakistanDepartment of Health Sciences, Khyber Medical College Peshawar, Peshawar, PakistanDepartment of Allied Health Sciences, Sarhad University of Information Technology, Peshawar, PakistanJiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing, ChinaDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaDepartment of Biochemistry, University of Malakand, Chakdara, Lower Dir, Khyber Pakhtunkhwa, 18000, PakistanDepartment of Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaHerein, capsaicin nanoparticles (NPs) were prepared by two different methods, namely, evaporative precipitation of nanosuspension (EPN) and anti-solvent precipitation with a syringe pump (APSP). The nanoparticles of the necessary sizes were obtained after optimizing experimental parameters such as the solvent-to-anti-solvent ratio and stirring speed. They had spherical shapes and an average diameter of 171.29 ± 1.94 and 78.91 ± 0.54 nm when prepared using the EPN and APSP methods, respectively. Differential scanning calorimetry and an X-ray diffractometer showed that the capsaicin crystallinity decreased. FTIR results showed that the NPs were produced with their original configuration and did not result in the synthesis of any additional structures. The NP formulation had a desirable drug content. They surpassed the unprocessed drug in solubility and displayed the desired stability. Capsaicin NP cream showed many folds of enhanced analgesic, anti-inflammatory, and antimicrobial effects compared to unprocessed capsaicin.https://doi.org/10.1515/gps-2023-0206analgesicantibacterialantifungalanti-inflammatorycapsaicin nanoparticles |
| spellingShingle | Sher Mujahid Hussain Ishtiaq Khan Farhat Ali Zahoor Muhammad Sher Wiaam Mujahid Khalil Muhammad Saqib Sulaiman Muhammad Ullah Riaz Naz Sumaira Ali Essam A. Synthesis and characterization of capsaicin nanoparticles: An attempt to enhance its bioavailability and pharmacological actions Green Processing and Synthesis analgesic antibacterial antifungal anti-inflammatory capsaicin nanoparticles |
| title | Synthesis and characterization of capsaicin nanoparticles: An attempt to enhance its bioavailability and pharmacological actions |
| title_full | Synthesis and characterization of capsaicin nanoparticles: An attempt to enhance its bioavailability and pharmacological actions |
| title_fullStr | Synthesis and characterization of capsaicin nanoparticles: An attempt to enhance its bioavailability and pharmacological actions |
| title_full_unstemmed | Synthesis and characterization of capsaicin nanoparticles: An attempt to enhance its bioavailability and pharmacological actions |
| title_short | Synthesis and characterization of capsaicin nanoparticles: An attempt to enhance its bioavailability and pharmacological actions |
| title_sort | synthesis and characterization of capsaicin nanoparticles an attempt to enhance its bioavailability and pharmacological actions |
| topic | analgesic antibacterial antifungal anti-inflammatory capsaicin nanoparticles |
| url | https://doi.org/10.1515/gps-2023-0206 |
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