Role of Pseudogenes in Tumorigenesis
Functional genomics has provided evidence that the human genome transcribes a large number of non-coding genes in addition to protein-coding genes, including microRNAs and long non-coding RNAs (lncRNAs). Among the group of lncRNAs are pseudogenes that have not been paid attention in the past, compar...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-08-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/10/8/256 |
| _version_ | 1797762614504194048 |
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| author | Xinling Hu Liu Yang Yin-Yuan Mo |
| author_facet | Xinling Hu Liu Yang Yin-Yuan Mo |
| author_sort | Xinling Hu |
| collection | DOAJ |
| description | Functional genomics has provided evidence that the human genome transcribes a large number of non-coding genes in addition to protein-coding genes, including microRNAs and long non-coding RNAs (lncRNAs). Among the group of lncRNAs are pseudogenes that have not been paid attention in the past, compared to other members of lncRNAs. However, increasing evidence points the important role of pseudogenes in diverse cellular functions, and dysregulation of pseudogenes are often associated with various human diseases including cancer. Like other types of lncRNAs, pseudogenes can also function as master regulators for gene expression and thus, they can play a critical role in various aspects of tumorigenesis. In this review we discuss the latest developments in pseudogene research, focusing on how pseudogenes impact tumorigenesis through different gene regulation mechanisms. Given the high sequence homology with the corresponding parent genes, we also discuss challenges for pseudogene research. |
| first_indexed | 2024-03-12T19:29:56Z |
| format | Article |
| id | doaj.art-bf36646788654feb8e9680c3e0886ab9 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T19:29:56Z |
| publishDate | 2018-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-bf36646788654feb8e9680c3e0886ab92023-08-02T04:38:37ZengMDPI AGCancers2072-66942018-08-0110825610.3390/cancers10080256cancers10080256Role of Pseudogenes in TumorigenesisXinling Hu0Liu Yang1Yin-Yuan Mo2Department of Dermatology and Institute of Translation Medicine, Affiliated the First People’s Hospital of Chenzhou of University of South China, Chenzhou 423000, ChinaDepartment of Science & Research, Zhejiang Provincial People’s Hospital, Hangzhou 310014, ChinaCancer Institute, University of Mississippi Medical Center, Jackson, MS 39216, USAFunctional genomics has provided evidence that the human genome transcribes a large number of non-coding genes in addition to protein-coding genes, including microRNAs and long non-coding RNAs (lncRNAs). Among the group of lncRNAs are pseudogenes that have not been paid attention in the past, compared to other members of lncRNAs. However, increasing evidence points the important role of pseudogenes in diverse cellular functions, and dysregulation of pseudogenes are often associated with various human diseases including cancer. Like other types of lncRNAs, pseudogenes can also function as master regulators for gene expression and thus, they can play a critical role in various aspects of tumorigenesis. In this review we discuss the latest developments in pseudogene research, focusing on how pseudogenes impact tumorigenesis through different gene regulation mechanisms. Given the high sequence homology with the corresponding parent genes, we also discuss challenges for pseudogene research.http://www.mdpi.com/2072-6694/10/8/256LncRNApseudogenegene regulationceRNAmicroRNA |
| spellingShingle | Xinling Hu Liu Yang Yin-Yuan Mo Role of Pseudogenes in Tumorigenesis Cancers LncRNA pseudogene gene regulation ceRNA microRNA |
| title | Role of Pseudogenes in Tumorigenesis |
| title_full | Role of Pseudogenes in Tumorigenesis |
| title_fullStr | Role of Pseudogenes in Tumorigenesis |
| title_full_unstemmed | Role of Pseudogenes in Tumorigenesis |
| title_short | Role of Pseudogenes in Tumorigenesis |
| title_sort | role of pseudogenes in tumorigenesis |
| topic | LncRNA pseudogene gene regulation ceRNA microRNA |
| url | http://www.mdpi.com/2072-6694/10/8/256 |
| work_keys_str_mv | AT xinlinghu roleofpseudogenesintumorigenesis AT liuyang roleofpseudogenesintumorigenesis AT yinyuanmo roleofpseudogenesintumorigenesis |