THE ROLE OF WHITE BLOOD CELL COUNT IN PERIANAL PATHOLOGIES: A RETROSPECTIVE ANALYSIS OF HEMATOLOGIC MALIGNANCIES
Background and Objective: Perianal pathologies are the most common cause of perianal infections in patients with hematological malignancies. Perianal infection diagnosis in this group of patients is difficult, thus careful anorectal examination is necessary, with imaging modalities. The literature...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2022-06-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | https://www.mjhid.org/index.php/mjhid/article/view/4989 |
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| author | Bedrettin Orhan Fahir Özkalemkaş Vildan Özkocaman Büşra Gürbüz Tuba Ersal İbrahim Ethem Pınar Cumali Yalçın Ömer Candar Sinem Çubukçu Tuba Güllü Koca Rıdvan Ali |
| author_facet | Bedrettin Orhan Fahir Özkalemkaş Vildan Özkocaman Büşra Gürbüz Tuba Ersal İbrahim Ethem Pınar Cumali Yalçın Ömer Candar Sinem Çubukçu Tuba Güllü Koca Rıdvan Ali |
| author_sort | Bedrettin Orhan |
| collection | DOAJ |
| description |
Background and Objective: Perianal pathologies are the most common cause of perianal infections in patients with hematological malignancies. Perianal infection diagnosis in this group of patients is difficult, thus careful anorectal examination is necessary, with imaging modalities. The literature revealed a knowledge gap on the approach of anal pathologies in patients with neutropenia during diagnosis or chemotherapy. This study aimed to examine our institutional data of perianal complications and investigate the relationship among the white blood cell-neutrophil count, perianal lesion, and the type of treatment in patients with hematologic malignancies during the neutropenic period.
Methods: Patients with a hematologic malignancy, hospitalized for cytotoxic chemotherapy, complicated by perianal pathology, and documented by at least one imaging method were included in the study.
Results: A total of 42 patients were included in the study. The comparison between the groups revealed no statistical significance between the anal abscess formation and the neutrophil count and previous perianal pathology. A statistical significance in favor of acute myeloid leukemia was found between patient diagnosis and anal abscess development. An inverse relationship was found between the number of white blood cells at hospitalization and having an anal pathology operation. It was observed that patients with high white blood cell count were less operated on due to anal pathology.
Conclusions: In conclusion, this article has shown that white blood cell count at the time of hospitalization in patients with hematological malignancy, can affect the operation status of patients due to anal pathologies that may occur in the neutropenic period.
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| institution | Directory Open Access Journal |
| issn | 2035-3006 |
| language | English |
| last_indexed | 2025-02-17T23:08:14Z |
| publishDate | 2022-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj.art-bf37f0c3af524d97a00d6b8d9df8d4a12024-12-02T07:50:39ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062022-06-0114110.4084/MJHID.2022.051THE ROLE OF WHITE BLOOD CELL COUNT IN PERIANAL PATHOLOGIES: A RETROSPECTIVE ANALYSIS OF HEMATOLOGIC MALIGNANCIESBedrettin Orhan0Fahir Özkalemkaş1Vildan Özkocaman2Büşra Gürbüz3Tuba Ersal4İbrahim Ethem Pınar5Cumali Yalçın6Ömer Candar7Sinem Çubukçu8Tuba Güllü Koca9Rıdvan Ali10Uludag University, Faculty of Medicine, Department of Internal Medicine, Division of Hematology, BursaBursa Uludag University, Faculty of Medicine, Department of Internal Medicine, Division of Hematology, BursaUludag University, Faculty of Medicine, Department of Internal Medicine, Division of Hematology, BursaUludag University, Faculty of Medicine, Department of Internal Medicine, BursaUludag University, Faculty of Medicine, Department of Internal Medicine, Division of Hematology, BursaUludag University, Faculty of Medicine, Department of Internal Medicine, Division of Hematology, BursaUludag University, Faculty of Medicine, Department of Internal Medicine, Division of Hematology, BursaUludag University, Faculty of Medicine, Department of Internal Medicine, Division of Hematology, BursaUludag University, Faculty of Medicine, Department of Internal Medicine, Division of Hematology, BursaUludag University, Faculty of Medicine, Department of Internal Medicine, Division of Hematology, BursaUludag University, Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Bursa Background and Objective: Perianal pathologies are the most common cause of perianal infections in patients with hematological malignancies. Perianal infection diagnosis in this group of patients is difficult, thus careful anorectal examination is necessary, with imaging modalities. The literature revealed a knowledge gap on the approach of anal pathologies in patients with neutropenia during diagnosis or chemotherapy. This study aimed to examine our institutional data of perianal complications and investigate the relationship among the white blood cell-neutrophil count, perianal lesion, and the type of treatment in patients with hematologic malignancies during the neutropenic period. Methods: Patients with a hematologic malignancy, hospitalized for cytotoxic chemotherapy, complicated by perianal pathology, and documented by at least one imaging method were included in the study. Results: A total of 42 patients were included in the study. The comparison between the groups revealed no statistical significance between the anal abscess formation and the neutrophil count and previous perianal pathology. A statistical significance in favor of acute myeloid leukemia was found between patient diagnosis and anal abscess development. An inverse relationship was found between the number of white blood cells at hospitalization and having an anal pathology operation. It was observed that patients with high white blood cell count were less operated on due to anal pathology. Conclusions: In conclusion, this article has shown that white blood cell count at the time of hospitalization in patients with hematological malignancy, can affect the operation status of patients due to anal pathologies that may occur in the neutropenic period. https://www.mjhid.org/index.php/mjhid/article/view/4989Perianalacute leukemiawhite blood cell |
| spellingShingle | Bedrettin Orhan Fahir Özkalemkaş Vildan Özkocaman Büşra Gürbüz Tuba Ersal İbrahim Ethem Pınar Cumali Yalçın Ömer Candar Sinem Çubukçu Tuba Güllü Koca Rıdvan Ali THE ROLE OF WHITE BLOOD CELL COUNT IN PERIANAL PATHOLOGIES: A RETROSPECTIVE ANALYSIS OF HEMATOLOGIC MALIGNANCIES Mediterranean Journal of Hematology and Infectious Diseases Perianal acute leukemia white blood cell |
| title | THE ROLE OF WHITE BLOOD CELL COUNT IN PERIANAL PATHOLOGIES: A RETROSPECTIVE ANALYSIS OF HEMATOLOGIC MALIGNANCIES |
| title_full | THE ROLE OF WHITE BLOOD CELL COUNT IN PERIANAL PATHOLOGIES: A RETROSPECTIVE ANALYSIS OF HEMATOLOGIC MALIGNANCIES |
| title_fullStr | THE ROLE OF WHITE BLOOD CELL COUNT IN PERIANAL PATHOLOGIES: A RETROSPECTIVE ANALYSIS OF HEMATOLOGIC MALIGNANCIES |
| title_full_unstemmed | THE ROLE OF WHITE BLOOD CELL COUNT IN PERIANAL PATHOLOGIES: A RETROSPECTIVE ANALYSIS OF HEMATOLOGIC MALIGNANCIES |
| title_short | THE ROLE OF WHITE BLOOD CELL COUNT IN PERIANAL PATHOLOGIES: A RETROSPECTIVE ANALYSIS OF HEMATOLOGIC MALIGNANCIES |
| title_sort | role of white blood cell count in perianal pathologies a retrospective analysis of hematologic malignancies |
| topic | Perianal acute leukemia white blood cell |
| url | https://www.mjhid.org/index.php/mjhid/article/view/4989 |
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