fMRI changes during multi-limb movements in Parkinson’s disease
BackgroundWhile motor coordination problems are frequently reported among individuals with Parkinson’s disease (PD), the effects of the disease on the performance of multi-limb movements and the brain changes underlying impaired coordination are not well-documented.ObjectiveFunctional magnetic reson...
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| Format: | Article |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2023.1248636/full |
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| author | Jae Woo Chung Abigail E. Bower Ibrahim Malik Justin P. Martello Christopher A. Knight Christopher A. Knight John J. Jeka John J. Jeka Roxana G. Burciu Roxana G. Burciu |
| author_facet | Jae Woo Chung Abigail E. Bower Ibrahim Malik Justin P. Martello Christopher A. Knight Christopher A. Knight John J. Jeka John J. Jeka Roxana G. Burciu Roxana G. Burciu |
| author_sort | Jae Woo Chung |
| collection | DOAJ |
| description | BackgroundWhile motor coordination problems are frequently reported among individuals with Parkinson’s disease (PD), the effects of the disease on the performance of multi-limb movements and the brain changes underlying impaired coordination are not well-documented.ObjectiveFunctional magnetic resonance imaging (fMRI) was used to examine differences in brain activity during a task that involved the coordination of non-homologous limbs (i.e., ipsilateral hand and foot) in individuals with and without PD.MethodsParticipants included 20 PD and 20 healthy control participants (HC). They were instructed to generate force in a coordinated manner by simultaneously contracting their ipsilateral hand and foot. PD were tested off their antiparkinsonian medication and on their more affected side, whereas the side in controls was randomized.ResultsAlthough both groups were able to coordinate the two limbs to produce the expected level of force, PD had a slower rate of force production and relaxation compared to HC. Additionally, their globus pallidus and primary motor cortex were underactive, whereas their pre-supplementary motor area (pre-SMA) and lateral cerebellum were overactive relative to HC. Importantly, in PD, the fMRI activity within the pre-SMA correlated with the rate of force decrease.ConclusionMulti-limb force control deficits in PD appear to be related to widespread underactivation within the basal ganglia-cortical loop. An overactivation of higher-level motor regions within the prefrontal cortex and lateral cerebellum may reflect increased cognitive control and performance monitoring that emerges during more complex motor tasks such as those that involve the coordination of multiple limbs. |
| first_indexed | 2024-03-11T10:58:32Z |
| format | Article |
| id | doaj.art-bf38d8058f0447d1a493cc6df4e17953 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-03-11T10:58:32Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-bf38d8058f0447d1a493cc6df4e179532023-11-13T02:50:20ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612023-11-011710.3389/fnhum.2023.12486361248636fMRI changes during multi-limb movements in Parkinson’s diseaseJae Woo Chung0Abigail E. Bower1Ibrahim Malik2Justin P. Martello3Christopher A. Knight4Christopher A. Knight5John J. Jeka6John J. Jeka7Roxana G. Burciu8Roxana G. Burciu9Department of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, United StatesDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, United StatesCenter for Biomedical and Brain Imaging, University of Delaware, Newark, DE, United StatesDepartment of Neurosciences, Christiana Care Health System, Newark, DE, United StatesDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, United StatesInterdisciplinary Neuroscience Graduate Program, University of Delaware, Newark, DE, United StatesDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, United StatesInterdisciplinary Neuroscience Graduate Program, University of Delaware, Newark, DE, United StatesDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, United StatesInterdisciplinary Neuroscience Graduate Program, University of Delaware, Newark, DE, United StatesBackgroundWhile motor coordination problems are frequently reported among individuals with Parkinson’s disease (PD), the effects of the disease on the performance of multi-limb movements and the brain changes underlying impaired coordination are not well-documented.ObjectiveFunctional magnetic resonance imaging (fMRI) was used to examine differences in brain activity during a task that involved the coordination of non-homologous limbs (i.e., ipsilateral hand and foot) in individuals with and without PD.MethodsParticipants included 20 PD and 20 healthy control participants (HC). They were instructed to generate force in a coordinated manner by simultaneously contracting their ipsilateral hand and foot. PD were tested off their antiparkinsonian medication and on their more affected side, whereas the side in controls was randomized.ResultsAlthough both groups were able to coordinate the two limbs to produce the expected level of force, PD had a slower rate of force production and relaxation compared to HC. Additionally, their globus pallidus and primary motor cortex were underactive, whereas their pre-supplementary motor area (pre-SMA) and lateral cerebellum were overactive relative to HC. Importantly, in PD, the fMRI activity within the pre-SMA correlated with the rate of force decrease.ConclusionMulti-limb force control deficits in PD appear to be related to widespread underactivation within the basal ganglia-cortical loop. An overactivation of higher-level motor regions within the prefrontal cortex and lateral cerebellum may reflect increased cognitive control and performance monitoring that emerges during more complex motor tasks such as those that involve the coordination of multiple limbs.https://www.frontiersin.org/articles/10.3389/fnhum.2023.1248636/fullParkinson’s diseasefMRIforcecoordinationmulti-limb |
| spellingShingle | Jae Woo Chung Abigail E. Bower Ibrahim Malik Justin P. Martello Christopher A. Knight Christopher A. Knight John J. Jeka John J. Jeka Roxana G. Burciu Roxana G. Burciu fMRI changes during multi-limb movements in Parkinson’s disease Frontiers in Human Neuroscience Parkinson’s disease fMRI force coordination multi-limb |
| title | fMRI changes during multi-limb movements in Parkinson’s disease |
| title_full | fMRI changes during multi-limb movements in Parkinson’s disease |
| title_fullStr | fMRI changes during multi-limb movements in Parkinson’s disease |
| title_full_unstemmed | fMRI changes during multi-limb movements in Parkinson’s disease |
| title_short | fMRI changes during multi-limb movements in Parkinson’s disease |
| title_sort | fmri changes during multi limb movements in parkinson s disease |
| topic | Parkinson’s disease fMRI force coordination multi-limb |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2023.1248636/full |
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