Blood biomarkers of secondary outcomes following concussion: A systematic review
IntroductionBlood biomarkers have been identified as an alternative tool for predicting secondary outcomes following concussion. This systematic review aimed to summarize the literature on blood biomarkers of secondary outcomes following concussion in both pediatric and adult cohorts.MethodsA litera...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.989974/full |
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| author | Ella E. K. Swaney Ella E. K. Swaney Tengyi Cai Tengyi Cai Marc L. Seal Marc L. Seal Vera Ignjatovic Vera Ignjatovic Vera Ignjatovic Vera Ignjatovic |
| author_facet | Ella E. K. Swaney Ella E. K. Swaney Tengyi Cai Tengyi Cai Marc L. Seal Marc L. Seal Vera Ignjatovic Vera Ignjatovic Vera Ignjatovic Vera Ignjatovic |
| author_sort | Ella E. K. Swaney |
| collection | DOAJ |
| description | IntroductionBlood biomarkers have been identified as an alternative tool for predicting secondary outcomes following concussion. This systematic review aimed to summarize the literature on blood biomarkers of secondary outcomes following concussion in both pediatric and adult cohorts.MethodsA literature search of Embase, Medline and PubMed was conducted. Two reviewers independently assessed retrieved studies to determine inclusion in systematic review synthesis.ResultsA total of 1771 unique studies were retrieved, 58 of which were included in the final synthesis. S100B, GFAP and tau were identified as being associated with secondary outcomes following concussion. Seventeen percent of studies were performed in a solely pediatric setting.ConclusionsValidation of biomarkers associated with secondary outcomes following concussion have been largely limited by heterogeneous study cohorts and definitions of concussion and mTBI, presenting a hurdle for translation of these markers into clinical practice. Additionally, there was an underrepresentation of studies which investigated pediatric cohorts. Adult markers are not appropriate for children, therefore pediatric specific markers of secondary outcomes following concussion present the biggest gap in this field. |
| first_indexed | 2024-04-10T06:58:34Z |
| format | Article |
| id | doaj.art-bf3934fb10ce4608bb62b57bfd5f0378 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-10T06:58:34Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-bf3934fb10ce4608bb62b57bfd5f03782023-02-28T05:29:37ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-02-011410.3389/fneur.2023.989974989974Blood biomarkers of secondary outcomes following concussion: A systematic reviewElla E. K. Swaney0Ella E. K. Swaney1Tengyi Cai2Tengyi Cai3Marc L. Seal4Marc L. Seal5Vera Ignjatovic6Vera Ignjatovic7Vera Ignjatovic8Vera Ignjatovic9Department of Haematology, Murdoch Children's Research Institute, Melbourne, VIC, AustraliaDepartment of Paediatrics, University of Melbourne, Melbourne, VIC, AustraliaDepartment of Haematology, Murdoch Children's Research Institute, Melbourne, VIC, AustraliaDepartment of Paediatrics, University of Melbourne, Melbourne, VIC, AustraliaDepartment of Paediatrics, University of Melbourne, Melbourne, VIC, AustraliaDevelopmental Imaging, Murdoch Children's Research Institute, Melbourne, VIC, AustraliaDepartment of Haematology, Murdoch Children's Research Institute, Melbourne, VIC, AustraliaDepartment of Paediatrics, University of Melbourne, Melbourne, VIC, AustraliaInstitute for Clinical and Translational Research, Johns Hopkins All Children's Hospital, St. Petersburg, FL, United StatesDepartment of Pediatrics, Johns Hopkins University, Baltimore, MD, United StatesIntroductionBlood biomarkers have been identified as an alternative tool for predicting secondary outcomes following concussion. This systematic review aimed to summarize the literature on blood biomarkers of secondary outcomes following concussion in both pediatric and adult cohorts.MethodsA literature search of Embase, Medline and PubMed was conducted. Two reviewers independently assessed retrieved studies to determine inclusion in systematic review synthesis.ResultsA total of 1771 unique studies were retrieved, 58 of which were included in the final synthesis. S100B, GFAP and tau were identified as being associated with secondary outcomes following concussion. Seventeen percent of studies were performed in a solely pediatric setting.ConclusionsValidation of biomarkers associated with secondary outcomes following concussion have been largely limited by heterogeneous study cohorts and definitions of concussion and mTBI, presenting a hurdle for translation of these markers into clinical practice. Additionally, there was an underrepresentation of studies which investigated pediatric cohorts. Adult markers are not appropriate for children, therefore pediatric specific markers of secondary outcomes following concussion present the biggest gap in this field.https://www.frontiersin.org/articles/10.3389/fneur.2023.989974/fullconcussionmild traumatic brain injurybiomarkerssecondary outcomessystematic review |
| spellingShingle | Ella E. K. Swaney Ella E. K. Swaney Tengyi Cai Tengyi Cai Marc L. Seal Marc L. Seal Vera Ignjatovic Vera Ignjatovic Vera Ignjatovic Vera Ignjatovic Blood biomarkers of secondary outcomes following concussion: A systematic review Frontiers in Neurology concussion mild traumatic brain injury biomarkers secondary outcomes systematic review |
| title | Blood biomarkers of secondary outcomes following concussion: A systematic review |
| title_full | Blood biomarkers of secondary outcomes following concussion: A systematic review |
| title_fullStr | Blood biomarkers of secondary outcomes following concussion: A systematic review |
| title_full_unstemmed | Blood biomarkers of secondary outcomes following concussion: A systematic review |
| title_short | Blood biomarkers of secondary outcomes following concussion: A systematic review |
| title_sort | blood biomarkers of secondary outcomes following concussion a systematic review |
| topic | concussion mild traumatic brain injury biomarkers secondary outcomes systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.989974/full |
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