Trehalose attenuates development of nonalcoholic steatohepatitis associated with type 2 diabetes in TSOD mouse
Trehalose, a non-reducing disaccharide, induces autophagy. Trehalose mitigates insulin resistance and adipocyte hypertrophy in obese mice; however, its effect on the development of nonalcoholic steatohepatitis (NASH) associated with type 2 diabetes remains unknown. In this study, we investigated the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-05-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619301379 |
| _version_ | 1818667274667556864 |
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| author | Kazutoshi Murotomi Shigeyuki Arai Aki Suyama Akira Harashima Yoshihiro Nakajima |
| author_facet | Kazutoshi Murotomi Shigeyuki Arai Aki Suyama Akira Harashima Yoshihiro Nakajima |
| author_sort | Kazutoshi Murotomi |
| collection | DOAJ |
| description | Trehalose, a non-reducing disaccharide, induces autophagy. Trehalose mitigates insulin resistance and adipocyte hypertrophy in obese mice; however, its effect on the development of nonalcoholic steatohepatitis (NASH) associated with type 2 diabetes remains unknown. In this study, we investigated the effect of trehalose on the development of NASH in the Tsumura Suzuki Obese Diabetes (TSOD) mouse, a metabolic syndrome model characterized by obesity, type 2 diabetes, and NASH. We found that trehalose intake markedly inhibited histopathological features of NASH, particularly hepatic steatosis and liver cell injury, in TSOD mice. Trehalose intake attenuated increase in mesenteric adipose tissue weight, impaired glucose tolerance, and iron deposition in the duodenum, suggesting that trehalose prevents insulin resistance and iron absorption in TSOD mice. These findings indicate that trehalose attenuates the development of NASH associated with type 2 diabetes, and this attenuation may be mediated by prevention of lipid accumulation and iron absorption. |
| first_indexed | 2024-12-17T06:17:49Z |
| format | Article |
| id | doaj.art-bf39ab36d350475eaa17ad1354f8ae58 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T06:17:49Z |
| publishDate | 2019-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-bf39ab36d350475eaa17ad1354f8ae582022-12-21T22:00:28ZengElsevierJournal of Functional Foods1756-46462019-05-0156303311Trehalose attenuates development of nonalcoholic steatohepatitis associated with type 2 diabetes in TSOD mouseKazutoshi Murotomi0Shigeyuki Arai1Aki Suyama2Akira Harashima3Yoshihiro Nakajima4Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa 761-0395, Japan; Corresponding authors.Hayashibara Co., Ltd., Naka-ku, Okayama 702-8006, Japan; Corresponding authors.Hayashibara Co., Ltd., Naka-ku, Okayama 702-8006, JapanHayashibara Co., Ltd., Naka-ku, Okayama 702-8006, JapanHealth Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa 761-0395, JapanTrehalose, a non-reducing disaccharide, induces autophagy. Trehalose mitigates insulin resistance and adipocyte hypertrophy in obese mice; however, its effect on the development of nonalcoholic steatohepatitis (NASH) associated with type 2 diabetes remains unknown. In this study, we investigated the effect of trehalose on the development of NASH in the Tsumura Suzuki Obese Diabetes (TSOD) mouse, a metabolic syndrome model characterized by obesity, type 2 diabetes, and NASH. We found that trehalose intake markedly inhibited histopathological features of NASH, particularly hepatic steatosis and liver cell injury, in TSOD mice. Trehalose intake attenuated increase in mesenteric adipose tissue weight, impaired glucose tolerance, and iron deposition in the duodenum, suggesting that trehalose prevents insulin resistance and iron absorption in TSOD mice. These findings indicate that trehalose attenuates the development of NASH associated with type 2 diabetes, and this attenuation may be mediated by prevention of lipid accumulation and iron absorption.http://www.sciencedirect.com/science/article/pii/S1756464619301379TrehaloseNonalcoholic steatohepatitisDiabetesAdiposeIronTSOD mouse |
| spellingShingle | Kazutoshi Murotomi Shigeyuki Arai Aki Suyama Akira Harashima Yoshihiro Nakajima Trehalose attenuates development of nonalcoholic steatohepatitis associated with type 2 diabetes in TSOD mouse Journal of Functional Foods Trehalose Nonalcoholic steatohepatitis Diabetes Adipose Iron TSOD mouse |
| title | Trehalose attenuates development of nonalcoholic steatohepatitis associated with type 2 diabetes in TSOD mouse |
| title_full | Trehalose attenuates development of nonalcoholic steatohepatitis associated with type 2 diabetes in TSOD mouse |
| title_fullStr | Trehalose attenuates development of nonalcoholic steatohepatitis associated with type 2 diabetes in TSOD mouse |
| title_full_unstemmed | Trehalose attenuates development of nonalcoholic steatohepatitis associated with type 2 diabetes in TSOD mouse |
| title_short | Trehalose attenuates development of nonalcoholic steatohepatitis associated with type 2 diabetes in TSOD mouse |
| title_sort | trehalose attenuates development of nonalcoholic steatohepatitis associated with type 2 diabetes in tsod mouse |
| topic | Trehalose Nonalcoholic steatohepatitis Diabetes Adipose Iron TSOD mouse |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619301379 |
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