Copper metabolism and hepatocellular carcinoma: current insights
Copper is an essential trace element that acts as a cofactor in various enzyme active sites in the human body. It participates in numerous life activities, including lipid metabolism, energy metabolism, and neurotransmitter synthesis. The proposal of “Cuproptosis” has made copper metabolism-related...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-07-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1186659/full |
| _version_ | 1827907722137305088 |
|---|---|
| author | Cheng Zhou Jinqiu Yang Tong Liu Ran Jia Lin Yang Pengfei Sun Wenxia Zhao |
| author_facet | Cheng Zhou Jinqiu Yang Tong Liu Ran Jia Lin Yang Pengfei Sun Wenxia Zhao |
| author_sort | Cheng Zhou |
| collection | DOAJ |
| description | Copper is an essential trace element that acts as a cofactor in various enzyme active sites in the human body. It participates in numerous life activities, including lipid metabolism, energy metabolism, and neurotransmitter synthesis. The proposal of “Cuproptosis” has made copper metabolism-related pathways a research hotspot in the field of tumor therapy, which has attracted great attention. This review discusses the biological processes of copper uptake, transport, and storage in human cells. It highlights the mechanisms by which copper metabolism affects hepatocellular carcinogenesis and metastasis, including autophagy, apoptosis, vascular invasion, cuproptosis, and ferroptosis. Additionally, it summarizes the current clinical applications of copper metabolism-related drugs in antitumor therapy. |
| first_indexed | 2024-03-13T01:12:03Z |
| format | Article |
| id | doaj.art-bf3c6110e6ff4511b2f81c82df1cda1b |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-13T01:12:03Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-bf3c6110e6ff4511b2f81c82df1cda1b2023-07-05T17:50:10ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-07-011310.3389/fonc.2023.11866591186659Copper metabolism and hepatocellular carcinoma: current insightsCheng Zhou0Jinqiu Yang1Tong Liu2Ran Jia3Lin Yang4Pengfei Sun5Wenxia Zhao6The First College of Clinical Medicine, Henan University of Chinese Medicine, Zhengzhou, ChinaThe First College of Clinical Medicine, Henan University of Chinese Medicine, Zhengzhou, ChinaThe First College of Clinical Medicine, Henan University of Chinese Medicine, Zhengzhou, ChinaThe First College of Clinical Medicine, Henan University of Chinese Medicine, Zhengzhou, ChinaDepartment of Hepatobiliary Surgery, Xianyang Central Hospital Affiliated to Shaanxi University of Chinese Medicine, Xianyang, ChinaDepartment of Orthopaedics, Jiangsu Province Hospital of Chinese Medicine, Nanjing, ChinaThe First College of Clinical Medicine, Henan University of Chinese Medicine, Zhengzhou, ChinaCopper is an essential trace element that acts as a cofactor in various enzyme active sites in the human body. It participates in numerous life activities, including lipid metabolism, energy metabolism, and neurotransmitter synthesis. The proposal of “Cuproptosis” has made copper metabolism-related pathways a research hotspot in the field of tumor therapy, which has attracted great attention. This review discusses the biological processes of copper uptake, transport, and storage in human cells. It highlights the mechanisms by which copper metabolism affects hepatocellular carcinogenesis and metastasis, including autophagy, apoptosis, vascular invasion, cuproptosis, and ferroptosis. Additionally, it summarizes the current clinical applications of copper metabolism-related drugs in antitumor therapy.https://www.frontiersin.org/articles/10.3389/fonc.2023.1186659/fullcopperhepatocellular carcinomabiologytreatmentmolecular mechanismcancer |
| spellingShingle | Cheng Zhou Jinqiu Yang Tong Liu Ran Jia Lin Yang Pengfei Sun Wenxia Zhao Copper metabolism and hepatocellular carcinoma: current insights Frontiers in Oncology copper hepatocellular carcinoma biology treatment molecular mechanism cancer |
| title | Copper metabolism and hepatocellular carcinoma: current insights |
| title_full | Copper metabolism and hepatocellular carcinoma: current insights |
| title_fullStr | Copper metabolism and hepatocellular carcinoma: current insights |
| title_full_unstemmed | Copper metabolism and hepatocellular carcinoma: current insights |
| title_short | Copper metabolism and hepatocellular carcinoma: current insights |
| title_sort | copper metabolism and hepatocellular carcinoma current insights |
| topic | copper hepatocellular carcinoma biology treatment molecular mechanism cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1186659/full |
| work_keys_str_mv | AT chengzhou coppermetabolismandhepatocellularcarcinomacurrentinsights AT jinqiuyang coppermetabolismandhepatocellularcarcinomacurrentinsights AT tongliu coppermetabolismandhepatocellularcarcinomacurrentinsights AT ranjia coppermetabolismandhepatocellularcarcinomacurrentinsights AT linyang coppermetabolismandhepatocellularcarcinomacurrentinsights AT pengfeisun coppermetabolismandhepatocellularcarcinomacurrentinsights AT wenxiazhao coppermetabolismandhepatocellularcarcinomacurrentinsights |