Intravenous Treprostinil in Severe Inoperable Chronic Thromboembolic Pulmonary Hypertension Using Implantable Pumps—Single-Center Experience over More Than a Decade
The management of chronic thromboembolic pulmonary hypertension has significantly changed over the last decade with the availability of both specific therapies and interventional treatments. In parallel, implantable pumps for intravenous administration of treprostinil have broadened the spectrum of...
| Κύριοι συγγραφείς: | , , , , , , , |
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| Μορφή: | Άρθρο |
| Γλώσσα: | English |
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MDPI AG
2023-07-01
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| Σειρά: | Journal of Cardiovascular Development and Disease |
| Θέματα: | |
| Διαθέσιμο Online: | https://www.mdpi.com/2308-3425/10/8/318 |
| _version_ | 1827729587445956608 |
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| author | Regina Steringer-Mascherbauer Charlotte Huber Uwe Fröschl Dagmar Engleder Reinhold Függer Maria Lummersdorfer Ralf Lenhard Martin Martinek |
| author_facet | Regina Steringer-Mascherbauer Charlotte Huber Uwe Fröschl Dagmar Engleder Reinhold Függer Maria Lummersdorfer Ralf Lenhard Martin Martinek |
| author_sort | Regina Steringer-Mascherbauer |
| collection | DOAJ |
| description | The management of chronic thromboembolic pulmonary hypertension has significantly changed over the last decade with the availability of both specific therapies and interventional treatments. In parallel, implantable pumps for intravenous administration of treprostinil have broadened the spectrum of continuous prostanoid infusion. We evaluated the course of 17 consecutive patients with inoperable chronic thromboembolic pulmonary hypertension treated with treprostinil by means of an implantable infusion pump between 2011 and 2023 at our center. Complications associated with the infusion system were rare, leading to 0.4 unplanned surgical interventions during 17,160 patient days. No additional safety signals were detected, and clinical benefits achieved with subcutaneous treprostinil before pump implantation could be maintained in all patients. No catheter-related infections or thromboembolic events were observed. Implantable infusion pumps offer an attractive alternative to subcutaneous treprostinil for patients intolerant to the subcutaneous route, including those with chronic thromboembolic pulmonary hypertension. |
| first_indexed | 2024-03-10T23:51:47Z |
| format | Article |
| id | doaj.art-bf3df9b51e7342688a36ae3cf87c3c5f |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-10T23:51:47Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-bf3df9b51e7342688a36ae3cf87c3c5f2023-11-19T01:37:51ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252023-07-0110831810.3390/jcdd10080318Intravenous Treprostinil in Severe Inoperable Chronic Thromboembolic Pulmonary Hypertension Using Implantable Pumps—Single-Center Experience over More Than a DecadeRegina Steringer-Mascherbauer0Charlotte Huber1Uwe Fröschl2Dagmar Engleder3Reinhold Függer4Maria Lummersdorfer5Ralf Lenhard6Martin Martinek7Department of Cardiology, Ordensklinikum Linz GmbH Elisabethinen, 4020 Linz, AustriaDepartment of Cardiology, Ordensklinikum Linz GmbH Elisabethinen, 4020 Linz, AustriaDepartment of Surgery, Ordensklinikum Linz GmbH Elisabethinen, 4020 Linz, AustriaInstitute for Anesthesiology and Intensive Care, Ordensklinikum Linz GmbH Elisabethinen, 4020 Linz, AustriaDepartment of Surgery, Ordensklinikum Linz GmbH Elisabethinen, 4020 Linz, AustriaInstitute for Anesthesiology and Intensive Care, Ordensklinikum Linz GmbH Elisabethinen, 4020 Linz, AustriaOrphaCare GmbH, 1190 Vienna, AustriaDepartment of Cardiology, Ordensklinikum Linz GmbH Elisabethinen, 4020 Linz, AustriaThe management of chronic thromboembolic pulmonary hypertension has significantly changed over the last decade with the availability of both specific therapies and interventional treatments. In parallel, implantable pumps for intravenous administration of treprostinil have broadened the spectrum of continuous prostanoid infusion. We evaluated the course of 17 consecutive patients with inoperable chronic thromboembolic pulmonary hypertension treated with treprostinil by means of an implantable infusion pump between 2011 and 2023 at our center. Complications associated with the infusion system were rare, leading to 0.4 unplanned surgical interventions during 17,160 patient days. No additional safety signals were detected, and clinical benefits achieved with subcutaneous treprostinil before pump implantation could be maintained in all patients. No catheter-related infections or thromboembolic events were observed. Implantable infusion pumps offer an attractive alternative to subcutaneous treprostinil for patients intolerant to the subcutaneous route, including those with chronic thromboembolic pulmonary hypertension.https://www.mdpi.com/2308-3425/10/8/318chronic thromboembolic pulmonary hypertensionimplantable pumpintravenous treprostinil |
| spellingShingle | Regina Steringer-Mascherbauer Charlotte Huber Uwe Fröschl Dagmar Engleder Reinhold Függer Maria Lummersdorfer Ralf Lenhard Martin Martinek Intravenous Treprostinil in Severe Inoperable Chronic Thromboembolic Pulmonary Hypertension Using Implantable Pumps—Single-Center Experience over More Than a Decade Journal of Cardiovascular Development and Disease chronic thromboembolic pulmonary hypertension implantable pump intravenous treprostinil |
| title | Intravenous Treprostinil in Severe Inoperable Chronic Thromboembolic Pulmonary Hypertension Using Implantable Pumps—Single-Center Experience over More Than a Decade |
| title_full | Intravenous Treprostinil in Severe Inoperable Chronic Thromboembolic Pulmonary Hypertension Using Implantable Pumps—Single-Center Experience over More Than a Decade |
| title_fullStr | Intravenous Treprostinil in Severe Inoperable Chronic Thromboembolic Pulmonary Hypertension Using Implantable Pumps—Single-Center Experience over More Than a Decade |
| title_full_unstemmed | Intravenous Treprostinil in Severe Inoperable Chronic Thromboembolic Pulmonary Hypertension Using Implantable Pumps—Single-Center Experience over More Than a Decade |
| title_short | Intravenous Treprostinil in Severe Inoperable Chronic Thromboembolic Pulmonary Hypertension Using Implantable Pumps—Single-Center Experience over More Than a Decade |
| title_sort | intravenous treprostinil in severe inoperable chronic thromboembolic pulmonary hypertension using implantable pumps single center experience over more than a decade |
| topic | chronic thromboembolic pulmonary hypertension implantable pump intravenous treprostinil |
| url | https://www.mdpi.com/2308-3425/10/8/318 |
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