Study on Correlation between Lipid Accumulation Product and Thyroid Stimulating Hormone Levels in Hypothyroidism
Introduction: Cardiovascular Disease (CVD) is one of the established causes of mortality and morbidity in hypothyroid patients. A predictor of cardiovascular risk in hypothyroid patients becomes essential to prevent the occurrence of cardiac event. One such prognosticator of CVD is the Lipid Ac...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2021-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/14564/47082_CE(Ra1)_F[SK]_PF1(AG_SL)_PFA(SL)_PB(AG_OM)_PN(KM).pdf |
| Summary: | Introduction: Cardiovascular Disease (CVD) is one of the
established causes of mortality and morbidity in hypothyroid
patients. A predictor of cardiovascular risk in hypothyroid
patients becomes essential to prevent the occurrence of
cardiac event. One such prognosticator of CVD is the Lipid
Accumulation Product (LAP).
Aim: To compare the trend of LAP scores in hypothyroid patients
with that of healthy controls.
Materials and Methods: After obtaining approval from the
Ethics Committee, this cross-sectional study was conducted.
After obtaining written informed consent, details such as
age, gender, waist circumference, serum Thyroid Stimulating
Hormone (TSH), and serum triglyceride levels were collected.
LAP was calculated among study participants as follows: LAP for
men={Waist circumference (cm)-65}×{Triglyceride concentration
(mmol/L)}.
LAP for women={Waist circumference (cm)-58}×{Triglyceride
concentration (mmol/L)}. Statistical analysis was performed with
Microsoft excel and Statistical Package for the Social Sciences
(SPSS) software version 24.0 for Windows.
Results: The total number of participants were 118 among
which 59 (50%) were hypothyroid cases and 59 (50%)
were healthy controls. The two groups had statistically
significant difference in their LAP scores. The mean LAP
score among cases and controls was 38.6±15.6 cm.mmol/L
and 30.9±13.2 cm.mmol/L, respectively with a p-value of
0.004. The LAP scores showed positive correlation with TSH
levels with r-value of 0.784 and p-value <0.001 by Pearson’s
correlation.
Conclusion: The study concludes that there is a significant
correlation between LAP score and TSH levels and LAP scores
are significantly higher in hypothyroid patients. |
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| ISSN: | 2249-782X 0973-709X |