Activation of the aryl hydrocarbon receptor in inflammatory bowel disease: insights from gut microbiota
Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disease that affects more than 3.5 million people, with rising prevalence. It deeply affects patients’ daily life, increasing the burden on patients, families, and society. Presently, the etiology of IBD remains incompletely clari...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1279172/full |
| _version_ | 1797650849163378688 |
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| author | Jun-Jie Hou A-Huo Ma Yue-Hua Qin |
| author_facet | Jun-Jie Hou A-Huo Ma Yue-Hua Qin |
| author_sort | Jun-Jie Hou |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disease that affects more than 3.5 million people, with rising prevalence. It deeply affects patients’ daily life, increasing the burden on patients, families, and society. Presently, the etiology of IBD remains incompletely clarified, while emerging evidence has demonstrated that altered gut microbiota and decreased aryl hydrocarbon receptor (AHR) activity are closely associated with IBD. Furthermore, microbial metabolites are capable of AHR activation as AHR ligands, while the AHR, in turn, affects the microbiota through various pathways. In light of the complex connection among gut microbiota, the AHR, and IBD, it is urgent to review the latest research progress in this field. In this review, we describe the role of gut microbiota and AHR activation in IBD and discussed the crosstalk between gut microbiota and the AHR in the context of IBD. Taken as a whole, we propose new therapeutic strategies targeting the AHR–microbiota axis for IBD, even for other related diseases caused by AHR-microbiota dysbiosis. |
| first_indexed | 2024-03-11T16:07:39Z |
| format | Article |
| id | doaj.art-bf44246c515e4a83a5a908bf710d2036 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-11T16:07:39Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-bf44246c515e4a83a5a908bf710d20362023-10-24T23:26:39ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-10-011310.3389/fcimb.2023.12791721279172Activation of the aryl hydrocarbon receptor in inflammatory bowel disease: insights from gut microbiotaJun-Jie HouA-Huo MaYue-Hua QinInflammatory bowel disease (IBD) is a chronic inflammatory intestinal disease that affects more than 3.5 million people, with rising prevalence. It deeply affects patients’ daily life, increasing the burden on patients, families, and society. Presently, the etiology of IBD remains incompletely clarified, while emerging evidence has demonstrated that altered gut microbiota and decreased aryl hydrocarbon receptor (AHR) activity are closely associated with IBD. Furthermore, microbial metabolites are capable of AHR activation as AHR ligands, while the AHR, in turn, affects the microbiota through various pathways. In light of the complex connection among gut microbiota, the AHR, and IBD, it is urgent to review the latest research progress in this field. In this review, we describe the role of gut microbiota and AHR activation in IBD and discussed the crosstalk between gut microbiota and the AHR in the context of IBD. Taken as a whole, we propose new therapeutic strategies targeting the AHR–microbiota axis for IBD, even for other related diseases caused by AHR-microbiota dysbiosis.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1279172/fullinflammatory bowel diseasearyl hydrocarbon receptorgut microbiotainterplaytherapy |
| spellingShingle | Jun-Jie Hou A-Huo Ma Yue-Hua Qin Activation of the aryl hydrocarbon receptor in inflammatory bowel disease: insights from gut microbiota Frontiers in Cellular and Infection Microbiology inflammatory bowel disease aryl hydrocarbon receptor gut microbiota interplay therapy |
| title | Activation of the aryl hydrocarbon receptor in inflammatory bowel disease: insights from gut microbiota |
| title_full | Activation of the aryl hydrocarbon receptor in inflammatory bowel disease: insights from gut microbiota |
| title_fullStr | Activation of the aryl hydrocarbon receptor in inflammatory bowel disease: insights from gut microbiota |
| title_full_unstemmed | Activation of the aryl hydrocarbon receptor in inflammatory bowel disease: insights from gut microbiota |
| title_short | Activation of the aryl hydrocarbon receptor in inflammatory bowel disease: insights from gut microbiota |
| title_sort | activation of the aryl hydrocarbon receptor in inflammatory bowel disease insights from gut microbiota |
| topic | inflammatory bowel disease aryl hydrocarbon receptor gut microbiota interplay therapy |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1279172/full |
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