Somatostatin Receptor Targeted PET-Imaging for Diagnosis, Radiotherapy Planning and Theranostics of Meningiomas: A Systematic Review of the Literature
The aims of the present systematic review are to: (1) assess the diagnostic performance of somatostatin receptor (SSR)targeted positron emission tomography (PET) with different tracers and devices in patients affected by meningiomas; and (2) to evaluate the theranostic applications of peptide recept...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/7/1666 |
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| author | Luca Filippi Isabella Palumbo Oreste Bagni Orazio Schillaci Cynthia Aristei Barbara Palumbo |
| author_facet | Luca Filippi Isabella Palumbo Oreste Bagni Orazio Schillaci Cynthia Aristei Barbara Palumbo |
| author_sort | Luca Filippi |
| collection | DOAJ |
| description | The aims of the present systematic review are to: (1) assess the diagnostic performance of somatostatin receptor (SSR)targeted positron emission tomography (PET) with different tracers and devices in patients affected by meningiomas; and (2) to evaluate the theranostic applications of peptide receptor radionuclide therapy (PRRT) in meningiomas. A systematic literature search according to PRISMA criteria was made by using two main databases. Only studies published from 2011 up to March 2022 in the English language with ≥10 enrolled patients were selected. Following our research strategy, 17 studies were included for the assessment. Fourteen studies encompassed 534 patients, harboring 733 meningiomas, submitted to SSR-targeted PET/CT (<i>n</i> = 10) or PET/MRI (<i>n</i> = 4) for de novo diagnosis, recurrence detection, or radiation therapy (RT) planning (endpoint 1), while 3 studies included 69 patients with therapy-refractory meningiomas submitted to PRRT (endpoint 2). A relevant variation in methodology was registered among diagnostic studies, since only a minority of them reported histopathology as a reference standard. PET, especially when performed through PET/MRI, resulted particularly useful for the detection of meningiomas located in the skull base (SB) or next to the <i>falx cerebri</i>, significantly influencing RT planning. As far as it concerns PRRT studies, stable disease was obtained in the 66.6% of the treated patients, being grade 1–2 hematological toxicity the most common side effect. Of note, the wide range of the administered activities, the various utilized radiopharmaceuticals (<sup>90</sup>Y-DOTATOC and/or <sup>177</sup>Lu-DOTATATE), the lack of dosimetric studies hamper a clear definition of PRRT potential on meningiomas’ management. |
| first_indexed | 2024-03-09T03:31:47Z |
| format | Article |
| id | doaj.art-bf4463dfb21544d086635ce4df66b0fb |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T03:31:47Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-bf4463dfb21544d086635ce4df66b0fb2023-12-03T14:54:54ZengMDPI AGDiagnostics2075-44182022-07-01127166610.3390/diagnostics12071666Somatostatin Receptor Targeted PET-Imaging for Diagnosis, Radiotherapy Planning and Theranostics of Meningiomas: A Systematic Review of the LiteratureLuca Filippi0Isabella Palumbo1Oreste Bagni2Orazio Schillaci3Cynthia Aristei4Barbara Palumbo5Nuclear Medicine Unit, “Santa Maria Goretti” Hospital, Via Antonio Canova, 04100 Latina, ItalySection of Radiation Oncology, Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi 1, 06132 Perugia, ItalyNuclear Medicine Unit, “Santa Maria Goretti” Hospital, Via Antonio Canova, 04100 Latina, ItalyDepartment of Biomedicine and Prevention, University Tor Vergata, Viale Oxford 81, 00133 Rome, ItalySection of Radiation Oncology, Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi 1, 06132 Perugia, ItalySection of Nuclear Medicine and Health Physics, Department of Medicine and Surgery, Università Degli Studi di Perugia, Piazza Lucio Severi 1, 06132 Perugia, ItalyThe aims of the present systematic review are to: (1) assess the diagnostic performance of somatostatin receptor (SSR)targeted positron emission tomography (PET) with different tracers and devices in patients affected by meningiomas; and (2) to evaluate the theranostic applications of peptide receptor radionuclide therapy (PRRT) in meningiomas. A systematic literature search according to PRISMA criteria was made by using two main databases. Only studies published from 2011 up to March 2022 in the English language with ≥10 enrolled patients were selected. Following our research strategy, 17 studies were included for the assessment. Fourteen studies encompassed 534 patients, harboring 733 meningiomas, submitted to SSR-targeted PET/CT (<i>n</i> = 10) or PET/MRI (<i>n</i> = 4) for de novo diagnosis, recurrence detection, or radiation therapy (RT) planning (endpoint 1), while 3 studies included 69 patients with therapy-refractory meningiomas submitted to PRRT (endpoint 2). A relevant variation in methodology was registered among diagnostic studies, since only a minority of them reported histopathology as a reference standard. PET, especially when performed through PET/MRI, resulted particularly useful for the detection of meningiomas located in the skull base (SB) or next to the <i>falx cerebri</i>, significantly influencing RT planning. As far as it concerns PRRT studies, stable disease was obtained in the 66.6% of the treated patients, being grade 1–2 hematological toxicity the most common side effect. Of note, the wide range of the administered activities, the various utilized radiopharmaceuticals (<sup>90</sup>Y-DOTATOC and/or <sup>177</sup>Lu-DOTATATE), the lack of dosimetric studies hamper a clear definition of PRRT potential on meningiomas’ management.https://www.mdpi.com/2075-4418/12/7/1666meningiomaneuro-oncologyPET/CTPET/MRI<sup>68</sup>Ga-DOTA-peptidessomatostatin receptors |
| spellingShingle | Luca Filippi Isabella Palumbo Oreste Bagni Orazio Schillaci Cynthia Aristei Barbara Palumbo Somatostatin Receptor Targeted PET-Imaging for Diagnosis, Radiotherapy Planning and Theranostics of Meningiomas: A Systematic Review of the Literature Diagnostics meningioma neuro-oncology PET/CT PET/MRI <sup>68</sup>Ga-DOTA-peptides somatostatin receptors |
| title | Somatostatin Receptor Targeted PET-Imaging for Diagnosis, Radiotherapy Planning and Theranostics of Meningiomas: A Systematic Review of the Literature |
| title_full | Somatostatin Receptor Targeted PET-Imaging for Diagnosis, Radiotherapy Planning and Theranostics of Meningiomas: A Systematic Review of the Literature |
| title_fullStr | Somatostatin Receptor Targeted PET-Imaging for Diagnosis, Radiotherapy Planning and Theranostics of Meningiomas: A Systematic Review of the Literature |
| title_full_unstemmed | Somatostatin Receptor Targeted PET-Imaging for Diagnosis, Radiotherapy Planning and Theranostics of Meningiomas: A Systematic Review of the Literature |
| title_short | Somatostatin Receptor Targeted PET-Imaging for Diagnosis, Radiotherapy Planning and Theranostics of Meningiomas: A Systematic Review of the Literature |
| title_sort | somatostatin receptor targeted pet imaging for diagnosis radiotherapy planning and theranostics of meningiomas a systematic review of the literature |
| topic | meningioma neuro-oncology PET/CT PET/MRI <sup>68</sup>Ga-DOTA-peptides somatostatin receptors |
| url | https://www.mdpi.com/2075-4418/12/7/1666 |
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