Evaluation of the Antimicrobial Activity of a Formulation Containing Ascorbic Acid and Eudragit FS 30D Microparticles for the Controlled Release of a Curcumin–Boric Acid Solid Dispersion in Turkey Poults Infected with <i>Salmonella enteritidis</i>: A Therapeutic Model
The selection of components within a formulation or for treatment must stop being arbitrary and must be focused on scientific evidence that supports the inclusion of each one. Therefore, the objective of the present study was to obtain a formulation based on ascorbic acid (AA) and Eudragit FS 30D mi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/22/16186 |
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| author | Daniel Hernandez-Patlan Bruno Solis-Cruz Juan D. Latorre Jesus A. Maguey-Gonzalez Inkar Castellanos-Huerta Eric Beyssac Ghislain Garrait Alma Vázquez-Durán Raquel López-Arellano Abraham Méndez-Albores Billy M. Hargis Guillermo Tellez-Isaias |
| author_facet | Daniel Hernandez-Patlan Bruno Solis-Cruz Juan D. Latorre Jesus A. Maguey-Gonzalez Inkar Castellanos-Huerta Eric Beyssac Ghislain Garrait Alma Vázquez-Durán Raquel López-Arellano Abraham Méndez-Albores Billy M. Hargis Guillermo Tellez-Isaias |
| author_sort | Daniel Hernandez-Patlan |
| collection | DOAJ |
| description | The selection of components within a formulation or for treatment must stop being arbitrary and must be focused on scientific evidence that supports the inclusion of each one. Therefore, the objective of the present study was to obtain a formulation based on ascorbic acid (AA) and Eudragit FS 30D microparticles containing curcumin–boric acid (CUR–BA) considering interaction studies between the active components carried out via Fourier transform infrared spectrometry (FTIR) and differential scanning calorimetry (DSC) to minimize antagonistic effects, and comprehensively and effectively treat turkey poults infected with <i>Salmonella enteritidis</i> (<i>S. enteritidis</i>). The DSC and FTIR studies clearly demonstrated the interactions between AA, BA, and CUR. Consequently, the combination of AA with CUR and/or BA should be avoided, but not CUR and BA. Furthermore, the Eudragit FS 30D microparticles containing CUR–BA (SD CUR–BA MP) showed a limited release of CUR–BA in an acidic medium, but they were released at a pH 6.8–7.0, which reduced the interactions between CUR–BA and AA. Finally, in the <i>S. enteritidis</i> infection model, turkey poults treated with the combination of AA and SD CUR–BA MP presented lower counts of <i>S. enteritidis</i> in cecal tonsils after 10 days of treatment. These results pointed out that the use of an adequate combination of AA and CUR–BA as an integral treatment of <i>S. enteritidis</i> infections could be a viable option to replace the indiscriminate use of antibiotics. |
| first_indexed | 2024-03-09T16:46:14Z |
| format | Article |
| id | doaj.art-bf44d56478ba47358f7cd9fbb01327dd |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T16:46:14Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-bf44d56478ba47358f7cd9fbb01327dd2023-11-24T14:46:24ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-11-0124221618610.3390/ijms242216186Evaluation of the Antimicrobial Activity of a Formulation Containing Ascorbic Acid and Eudragit FS 30D Microparticles for the Controlled Release of a Curcumin–Boric Acid Solid Dispersion in Turkey Poults Infected with <i>Salmonella enteritidis</i>: A Therapeutic ModelDaniel Hernandez-Patlan0Bruno Solis-Cruz1Juan D. Latorre2Jesus A. Maguey-Gonzalez3Inkar Castellanos-Huerta4Eric Beyssac5Ghislain Garrait6Alma Vázquez-Durán7Raquel López-Arellano8Abraham Méndez-Albores9Billy M. Hargis10Guillermo Tellez-Isaias11Laboratory 5: LEDEFAR, Multidisciplinary Research Unit, Superior Studies Faculty at Cuautitlan (FESC), National Autonomous University of Mexico (UNAM), Cuautitlan Izcalli 54714, MexicoLaboratory 5: LEDEFAR, Multidisciplinary Research Unit, Superior Studies Faculty at Cuautitlan (FESC), National Autonomous University of Mexico (UNAM), Cuautitlan Izcalli 54714, MexicoDivision of Agriculture, Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USADivision of Agriculture, Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USADivision of Agriculture, Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USAUFR Pharmacie, UMR MEDIS, Université Clermont-Auvergne, F-63001 Clermont-Ferrand, FranceUFR Pharmacie, UMR MEDIS, Université Clermont-Auvergne, F-63001 Clermont-Ferrand, FranceUnidad de Investigación Multidisciplinaria L14 (Alimentos, Micotoxinas y Micotoxicosis), Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Cuautitlán Izcalli 54714, MexicoLaboratory 5: LEDEFAR, Multidisciplinary Research Unit, Superior Studies Faculty at Cuautitlan (FESC), National Autonomous University of Mexico (UNAM), Cuautitlan Izcalli 54714, MexicoUnidad de Investigación Multidisciplinaria L14 (Alimentos, Micotoxinas y Micotoxicosis), Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Cuautitlán Izcalli 54714, MexicoDivision of Agriculture, Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USADivision of Agriculture, Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USAThe selection of components within a formulation or for treatment must stop being arbitrary and must be focused on scientific evidence that supports the inclusion of each one. Therefore, the objective of the present study was to obtain a formulation based on ascorbic acid (AA) and Eudragit FS 30D microparticles containing curcumin–boric acid (CUR–BA) considering interaction studies between the active components carried out via Fourier transform infrared spectrometry (FTIR) and differential scanning calorimetry (DSC) to minimize antagonistic effects, and comprehensively and effectively treat turkey poults infected with <i>Salmonella enteritidis</i> (<i>S. enteritidis</i>). The DSC and FTIR studies clearly demonstrated the interactions between AA, BA, and CUR. Consequently, the combination of AA with CUR and/or BA should be avoided, but not CUR and BA. Furthermore, the Eudragit FS 30D microparticles containing CUR–BA (SD CUR–BA MP) showed a limited release of CUR–BA in an acidic medium, but they were released at a pH 6.8–7.0, which reduced the interactions between CUR–BA and AA. Finally, in the <i>S. enteritidis</i> infection model, turkey poults treated with the combination of AA and SD CUR–BA MP presented lower counts of <i>S. enteritidis</i> in cecal tonsils after 10 days of treatment. These results pointed out that the use of an adequate combination of AA and CUR–BA as an integral treatment of <i>S. enteritidis</i> infections could be a viable option to replace the indiscriminate use of antibiotics.https://www.mdpi.com/1422-0067/24/22/16186<i>S. enteritidis</i>Eudragit FS 30Dcurcuminboric acidascorbic acidinteraction studies |
| spellingShingle | Daniel Hernandez-Patlan Bruno Solis-Cruz Juan D. Latorre Jesus A. Maguey-Gonzalez Inkar Castellanos-Huerta Eric Beyssac Ghislain Garrait Alma Vázquez-Durán Raquel López-Arellano Abraham Méndez-Albores Billy M. Hargis Guillermo Tellez-Isaias Evaluation of the Antimicrobial Activity of a Formulation Containing Ascorbic Acid and Eudragit FS 30D Microparticles for the Controlled Release of a Curcumin–Boric Acid Solid Dispersion in Turkey Poults Infected with <i>Salmonella enteritidis</i>: A Therapeutic Model International Journal of Molecular Sciences <i>S. enteritidis</i> Eudragit FS 30D curcumin boric acid ascorbic acid interaction studies |
| title | Evaluation of the Antimicrobial Activity of a Formulation Containing Ascorbic Acid and Eudragit FS 30D Microparticles for the Controlled Release of a Curcumin–Boric Acid Solid Dispersion in Turkey Poults Infected with <i>Salmonella enteritidis</i>: A Therapeutic Model |
| title_full | Evaluation of the Antimicrobial Activity of a Formulation Containing Ascorbic Acid and Eudragit FS 30D Microparticles for the Controlled Release of a Curcumin–Boric Acid Solid Dispersion in Turkey Poults Infected with <i>Salmonella enteritidis</i>: A Therapeutic Model |
| title_fullStr | Evaluation of the Antimicrobial Activity of a Formulation Containing Ascorbic Acid and Eudragit FS 30D Microparticles for the Controlled Release of a Curcumin–Boric Acid Solid Dispersion in Turkey Poults Infected with <i>Salmonella enteritidis</i>: A Therapeutic Model |
| title_full_unstemmed | Evaluation of the Antimicrobial Activity of a Formulation Containing Ascorbic Acid and Eudragit FS 30D Microparticles for the Controlled Release of a Curcumin–Boric Acid Solid Dispersion in Turkey Poults Infected with <i>Salmonella enteritidis</i>: A Therapeutic Model |
| title_short | Evaluation of the Antimicrobial Activity of a Formulation Containing Ascorbic Acid and Eudragit FS 30D Microparticles for the Controlled Release of a Curcumin–Boric Acid Solid Dispersion in Turkey Poults Infected with <i>Salmonella enteritidis</i>: A Therapeutic Model |
| title_sort | evaluation of the antimicrobial activity of a formulation containing ascorbic acid and eudragit fs 30d microparticles for the controlled release of a curcumin boric acid solid dispersion in turkey poults infected with i salmonella enteritidis i a therapeutic model |
| topic | <i>S. enteritidis</i> Eudragit FS 30D curcumin boric acid ascorbic acid interaction studies |
| url | https://www.mdpi.com/1422-0067/24/22/16186 |
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