Mid-Regional Proadrenomedullin as a New Biomarker of Kidney and Cardiovascular Diseases—Is It the Future?
The increasing prevalence of cardiovascular disease and concomitant chronic kidney disease among the aging populations is responsible for considerable growth of mortality. Additionally, frequent, prolonged hospitalizations and long-term treatment generates progressive decline in bodily functions as...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/3/524 |
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| author | Katarzyna Czajkowska Edyta Zbroch Angelika Bielach-Bazyluk Katarzyna Mitrosz Elzbieta Bujno Katarzyna Kakareko Alicja Rydzewska-Rosolowska Tomasz Hryszko |
| author_facet | Katarzyna Czajkowska Edyta Zbroch Angelika Bielach-Bazyluk Katarzyna Mitrosz Elzbieta Bujno Katarzyna Kakareko Alicja Rydzewska-Rosolowska Tomasz Hryszko |
| author_sort | Katarzyna Czajkowska |
| collection | DOAJ |
| description | The increasing prevalence of cardiovascular disease and concomitant chronic kidney disease among the aging populations is responsible for considerable growth of mortality. Additionally, frequent, prolonged hospitalizations and long-term treatment generates progressive decline in bodily functions as well as substantial public health and economic burden. Accessibility to easy, non-invasive prognostic markers able to detect patients at risk of cardiovascular events may improve effective therapy and mitigate disease progression. Moreover, an early diagnosis allows time for implementation of prophylactic and educational programs that may result in decreased morbidity, improved quality of life and reduced public health expenditure. One of the promising candidates for a novel cardiovascular biomarker is mid-regional proadrenomedullin, a derivative of adrenomedullin. Adrenomedullin is a peptide hormone known for its vasodilatory, antioxidant, antiapoptotic and antifibrotic effects. A remarkable advantage of mid-regional proadrenomedullin is its longer half-life which is a prerequisite for plasma measurements. These review aims to discuss the importance of mid-regional proadrenomedullin with reference to its usefulness as a biomarker of increased cardiovascular risk and kidney disease progression. |
| first_indexed | 2024-03-09T06:08:44Z |
| format | Article |
| id | doaj.art-bf470e0b194d4d14a1b60e7f8e93f55c |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T06:08:44Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-bf470e0b194d4d14a1b60e7f8e93f55c2023-12-03T12:00:49ZengMDPI AGJournal of Clinical Medicine2077-03832021-02-0110352410.3390/jcm10030524Mid-Regional Proadrenomedullin as a New Biomarker of Kidney and Cardiovascular Diseases—Is It the Future?Katarzyna Czajkowska0Edyta Zbroch1Angelika Bielach-Bazyluk2Katarzyna Mitrosz3Elzbieta Bujno4Katarzyna Kakareko5Alicja Rydzewska-Rosolowska6Tomasz Hryszko72nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, 15-276 Bialystok, PolandDepartment of Internal Medicine and Hypertension, Medical University of Bialystok, 15-540 Bialystok, Poland2nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, 15-276 Bialystok, Poland2nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, 15-276 Bialystok, PolandDepartment of Internal Medicine and Hypertension, Medical University of Bialystok, 15-540 Bialystok, Poland2nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, 15-276 Bialystok, Poland2nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, 15-276 Bialystok, Poland2nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, 15-276 Bialystok, PolandThe increasing prevalence of cardiovascular disease and concomitant chronic kidney disease among the aging populations is responsible for considerable growth of mortality. Additionally, frequent, prolonged hospitalizations and long-term treatment generates progressive decline in bodily functions as well as substantial public health and economic burden. Accessibility to easy, non-invasive prognostic markers able to detect patients at risk of cardiovascular events may improve effective therapy and mitigate disease progression. Moreover, an early diagnosis allows time for implementation of prophylactic and educational programs that may result in decreased morbidity, improved quality of life and reduced public health expenditure. One of the promising candidates for a novel cardiovascular biomarker is mid-regional proadrenomedullin, a derivative of adrenomedullin. Adrenomedullin is a peptide hormone known for its vasodilatory, antioxidant, antiapoptotic and antifibrotic effects. A remarkable advantage of mid-regional proadrenomedullin is its longer half-life which is a prerequisite for plasma measurements. These review aims to discuss the importance of mid-regional proadrenomedullin with reference to its usefulness as a biomarker of increased cardiovascular risk and kidney disease progression.https://www.mdpi.com/2077-0383/10/3/524cardiovascular diseaseskidney diseasesmid-regional proadrenomedullin |
| spellingShingle | Katarzyna Czajkowska Edyta Zbroch Angelika Bielach-Bazyluk Katarzyna Mitrosz Elzbieta Bujno Katarzyna Kakareko Alicja Rydzewska-Rosolowska Tomasz Hryszko Mid-Regional Proadrenomedullin as a New Biomarker of Kidney and Cardiovascular Diseases—Is It the Future? Journal of Clinical Medicine cardiovascular diseases kidney diseases mid-regional proadrenomedullin |
| title | Mid-Regional Proadrenomedullin as a New Biomarker of Kidney and Cardiovascular Diseases—Is It the Future? |
| title_full | Mid-Regional Proadrenomedullin as a New Biomarker of Kidney and Cardiovascular Diseases—Is It the Future? |
| title_fullStr | Mid-Regional Proadrenomedullin as a New Biomarker of Kidney and Cardiovascular Diseases—Is It the Future? |
| title_full_unstemmed | Mid-Regional Proadrenomedullin as a New Biomarker of Kidney and Cardiovascular Diseases—Is It the Future? |
| title_short | Mid-Regional Proadrenomedullin as a New Biomarker of Kidney and Cardiovascular Diseases—Is It the Future? |
| title_sort | mid regional proadrenomedullin as a new biomarker of kidney and cardiovascular diseases is it the future |
| topic | cardiovascular diseases kidney diseases mid-regional proadrenomedullin |
| url | https://www.mdpi.com/2077-0383/10/3/524 |
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