Aberrant DNA methylation profile exacerbates inflammation and neurodegeneration in multiple sclerosis patients
Abstract Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous system characterised by incoordination, sensory loss, weakness, changes in bladder capacity and bowel function, fatigue and cognitive impairment, creating a significant socioeconomic burden. The pathog...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2020-01-01
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| Series: | Journal of Neuroinflammation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12974-019-1667-1 |
| _version_ | 1811270818227814400 |
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| author | Naiara Celarain Jordi Tomas-Roig |
| author_facet | Naiara Celarain Jordi Tomas-Roig |
| author_sort | Naiara Celarain |
| collection | DOAJ |
| description | Abstract Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous system characterised by incoordination, sensory loss, weakness, changes in bladder capacity and bowel function, fatigue and cognitive impairment, creating a significant socioeconomic burden. The pathogenesis of MS involves both genetic susceptibility and exposure to distinct environmental risk factors. The gene x environment interaction is regulated by epigenetic mechanisms. Epigenetics refers to a complex system that modifies gene expression without altering the DNA sequence. The most studied epigenetic mechanism is DNA methylation. This epigenetic mark participates in distinct MS pathophysiological processes, including blood–brain barrier breakdown, inflammatory response, demyelination, remyelination failure and neurodegeneration. In this study, we also accurately summarised a list of environmental factors involved in the MS pathogenesis and its clinical course. A literature search was conducted using MEDLINE through PubMED and Scopus. In conclusion, an exhaustive study of DNA methylation might contribute towards new pharmacological interventions in MS by use of epigenetic drugs. |
| first_indexed | 2024-04-12T22:08:57Z |
| format | Article |
| id | doaj.art-bf475c5003d34f4a833464b04d4989ec |
| institution | Directory Open Access Journal |
| issn | 1742-2094 |
| language | English |
| last_indexed | 2024-04-12T22:08:57Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj.art-bf475c5003d34f4a833464b04d4989ec2022-12-22T03:14:50ZengBMCJournal of Neuroinflammation1742-20942020-01-0117111710.1186/s12974-019-1667-1Aberrant DNA methylation profile exacerbates inflammation and neurodegeneration in multiple sclerosis patientsNaiara Celarain0Jordi Tomas-Roig1Girona Neuroimmunology and Multiple Sclerosis Unit (UNIEM), Dr. Josep Trueta University Hospital and Girona Biomedical Research Institute (IDIBGI)Girona Neuroimmunology and Multiple Sclerosis Unit (UNIEM), Dr. Josep Trueta University Hospital and Girona Biomedical Research Institute (IDIBGI)Abstract Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous system characterised by incoordination, sensory loss, weakness, changes in bladder capacity and bowel function, fatigue and cognitive impairment, creating a significant socioeconomic burden. The pathogenesis of MS involves both genetic susceptibility and exposure to distinct environmental risk factors. The gene x environment interaction is regulated by epigenetic mechanisms. Epigenetics refers to a complex system that modifies gene expression without altering the DNA sequence. The most studied epigenetic mechanism is DNA methylation. This epigenetic mark participates in distinct MS pathophysiological processes, including blood–brain barrier breakdown, inflammatory response, demyelination, remyelination failure and neurodegeneration. In this study, we also accurately summarised a list of environmental factors involved in the MS pathogenesis and its clinical course. A literature search was conducted using MEDLINE through PubMED and Scopus. In conclusion, an exhaustive study of DNA methylation might contribute towards new pharmacological interventions in MS by use of epigenetic drugs.https://doi.org/10.1186/s12974-019-1667-1Multiple sclerosisDNA methylationEnvironmental risk factorsInflammationNeurodegeneration |
| spellingShingle | Naiara Celarain Jordi Tomas-Roig Aberrant DNA methylation profile exacerbates inflammation and neurodegeneration in multiple sclerosis patients Journal of Neuroinflammation Multiple sclerosis DNA methylation Environmental risk factors Inflammation Neurodegeneration |
| title | Aberrant DNA methylation profile exacerbates inflammation and neurodegeneration in multiple sclerosis patients |
| title_full | Aberrant DNA methylation profile exacerbates inflammation and neurodegeneration in multiple sclerosis patients |
| title_fullStr | Aberrant DNA methylation profile exacerbates inflammation and neurodegeneration in multiple sclerosis patients |
| title_full_unstemmed | Aberrant DNA methylation profile exacerbates inflammation and neurodegeneration in multiple sclerosis patients |
| title_short | Aberrant DNA methylation profile exacerbates inflammation and neurodegeneration in multiple sclerosis patients |
| title_sort | aberrant dna methylation profile exacerbates inflammation and neurodegeneration in multiple sclerosis patients |
| topic | Multiple sclerosis DNA methylation Environmental risk factors Inflammation Neurodegeneration |
| url | https://doi.org/10.1186/s12974-019-1667-1 |
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