Efficacy of treatment patterns based on concurrent chemoradiotherapy in patients with stage IIB cervical squamous cell carcinoma
Abstract Purpose To assess survival of treatment patterns based on concurrent chemoradiotherapy (CCRT) in patients with stage IIB cervical squamous cell carcinoma (CSCC). Materials and methods Patients with stage IIB CSCC receiving CCRT were investigated from June 2012 to June 2019 in Guangxi Medica...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-023-11372-6 |
| _version_ | 1797349880914509824 |
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| author | Xin-Bin Pan Yan Lu You-Sheng Wei De-Sheng Yao |
| author_facet | Xin-Bin Pan Yan Lu You-Sheng Wei De-Sheng Yao |
| author_sort | Xin-Bin Pan |
| collection | DOAJ |
| description | Abstract Purpose To assess survival of treatment patterns based on concurrent chemoradiotherapy (CCRT) in patients with stage IIB cervical squamous cell carcinoma (CSCC). Materials and methods Patients with stage IIB CSCC receiving CCRT were investigated from June 2012 to June 2019 in Guangxi Medical University Cancer Hospital. Baseline characteristics and treatment patterns were described. Survival between treatment patterns were compared using Kaplan-Meier methods. Results A total of 232 patients were included: 39.7% of patients received CCRT alone, 6.5% of patients received neoadjuvant chemotherapy (NACT) + CCRT, 45.6% of patients received CCRT + adjuvant chemotherapy (AC), and 8.2% of patients received NACT + CCRT + AC. CCRT + AC showed similar overall survival (OS; hazard ratio [HR] = 0.95, 95% confidence interval [CI]: 0.41–2.17; P = 0.894) and locoregional-free survival (LRFS; HR = 2.39, 95% CI: 0.45–12.63; P = 0.303) compared with CCRT. However, CCRT + AC had a worse distant metastasis-free survival (DMFS; HR = 5.39, 95% CI: 1.14–25.57; P = 0.034). After propensity score matching, CCRT + AC had comparable OS (HR = 0.89, 95% CI: 0.29–2.70; P = 0.833), LRFS (HR = 3.26, 95% CI: 0.30-35.38; P = 0.331), and DMFS (HR = 4.80, 95% CI: 0.55–42.26; P = 0.157) compared to CCRT. Conclusion AC did not improve survival in patients with stage IIB CSCC receiving CCRT. |
| first_indexed | 2024-03-08T12:36:47Z |
| format | Article |
| id | doaj.art-bf4917d5edf04b6eb2960f4297ba343a |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-08T12:36:47Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-bf4917d5edf04b6eb2960f4297ba343a2024-01-21T12:24:32ZengBMCBMC Cancer1471-24072024-01-0124111010.1186/s12885-023-11372-6Efficacy of treatment patterns based on concurrent chemoradiotherapy in patients with stage IIB cervical squamous cell carcinomaXin-Bin Pan0Yan Lu1You-Sheng Wei2De-Sheng Yao3Department of Radiation Oncology, Guangxi Medical University Cancer HospitalDepartment of Gynecologic Oncology, Guangxi Medical University Cancer HospitalDepartment of Gynecologic Oncology, Guangxi Medical University Cancer HospitalDepartment of Gynecologic Oncology, Guangxi Medical University Cancer HospitalAbstract Purpose To assess survival of treatment patterns based on concurrent chemoradiotherapy (CCRT) in patients with stage IIB cervical squamous cell carcinoma (CSCC). Materials and methods Patients with stage IIB CSCC receiving CCRT were investigated from June 2012 to June 2019 in Guangxi Medical University Cancer Hospital. Baseline characteristics and treatment patterns were described. Survival between treatment patterns were compared using Kaplan-Meier methods. Results A total of 232 patients were included: 39.7% of patients received CCRT alone, 6.5% of patients received neoadjuvant chemotherapy (NACT) + CCRT, 45.6% of patients received CCRT + adjuvant chemotherapy (AC), and 8.2% of patients received NACT + CCRT + AC. CCRT + AC showed similar overall survival (OS; hazard ratio [HR] = 0.95, 95% confidence interval [CI]: 0.41–2.17; P = 0.894) and locoregional-free survival (LRFS; HR = 2.39, 95% CI: 0.45–12.63; P = 0.303) compared with CCRT. However, CCRT + AC had a worse distant metastasis-free survival (DMFS; HR = 5.39, 95% CI: 1.14–25.57; P = 0.034). After propensity score matching, CCRT + AC had comparable OS (HR = 0.89, 95% CI: 0.29–2.70; P = 0.833), LRFS (HR = 3.26, 95% CI: 0.30-35.38; P = 0.331), and DMFS (HR = 4.80, 95% CI: 0.55–42.26; P = 0.157) compared to CCRT. Conclusion AC did not improve survival in patients with stage IIB CSCC receiving CCRT.https://doi.org/10.1186/s12885-023-11372-6Cervical squamous cell carcinomaCSCCRadiotherapyChemotherapyStage IIB |
| spellingShingle | Xin-Bin Pan Yan Lu You-Sheng Wei De-Sheng Yao Efficacy of treatment patterns based on concurrent chemoradiotherapy in patients with stage IIB cervical squamous cell carcinoma BMC Cancer Cervical squamous cell carcinoma CSCC Radiotherapy Chemotherapy Stage IIB |
| title | Efficacy of treatment patterns based on concurrent chemoradiotherapy in patients with stage IIB cervical squamous cell carcinoma |
| title_full | Efficacy of treatment patterns based on concurrent chemoradiotherapy in patients with stage IIB cervical squamous cell carcinoma |
| title_fullStr | Efficacy of treatment patterns based on concurrent chemoradiotherapy in patients with stage IIB cervical squamous cell carcinoma |
| title_full_unstemmed | Efficacy of treatment patterns based on concurrent chemoradiotherapy in patients with stage IIB cervical squamous cell carcinoma |
| title_short | Efficacy of treatment patterns based on concurrent chemoradiotherapy in patients with stage IIB cervical squamous cell carcinoma |
| title_sort | efficacy of treatment patterns based on concurrent chemoradiotherapy in patients with stage iib cervical squamous cell carcinoma |
| topic | Cervical squamous cell carcinoma CSCC Radiotherapy Chemotherapy Stage IIB |
| url | https://doi.org/10.1186/s12885-023-11372-6 |
| work_keys_str_mv | AT xinbinpan efficacyoftreatmentpatternsbasedonconcurrentchemoradiotherapyinpatientswithstageiibcervicalsquamouscellcarcinoma AT yanlu efficacyoftreatmentpatternsbasedonconcurrentchemoradiotherapyinpatientswithstageiibcervicalsquamouscellcarcinoma AT youshengwei efficacyoftreatmentpatternsbasedonconcurrentchemoradiotherapyinpatientswithstageiibcervicalsquamouscellcarcinoma AT deshengyao efficacyoftreatmentpatternsbasedonconcurrentchemoradiotherapyinpatientswithstageiibcervicalsquamouscellcarcinoma |