Probing the Unknowns in Cytokinin-Mediated Immune Defense in with Systems Biology Approaches
Plant hormones involving salicylic acid (SA), jasmonic acid (JA), ethylene (Et), and auxin, gibberellins, and abscisic acid (ABA) are known to regulate host immune responses. However, plant hormone cytokinin has the potential to modulate defense signaling including SA and JA. It promotes plant patho...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2014-01-01
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| Series: | Bioinformatics and Biology Insights |
| Online Access: | https://doi.org/10.4137/BBI.S13462 |
| _version_ | 1819064152460623872 |
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| author | Muhammad Naseem Meik Kunz Thomas Dandekar |
| author_facet | Muhammad Naseem Meik Kunz Thomas Dandekar |
| author_sort | Muhammad Naseem |
| collection | DOAJ |
| description | Plant hormones involving salicylic acid (SA), jasmonic acid (JA), ethylene (Et), and auxin, gibberellins, and abscisic acid (ABA) are known to regulate host immune responses. However, plant hormone cytokinin has the potential to modulate defense signaling including SA and JA. It promotes plant pathogen and herbivore resistance; underlying mechanisms are still unknown. Using systems biology approaches, we unravel hub points of immune interaction mediated by cytokinin signaling in Arabidopsis. High-confidence Arabidopsis protein—protein interactions (PPI) are coupled to changes in cytokinin-mediated gene expression. Nodes of the cellular interactome that are enriched in immune functions also reconstitute sub-networks. Topological analyses and their specific immunological relevance lead to the identification of functional hubs in cellular interactome. We discuss our identified immune hubs in light of an emerging model of cytokinin-mediated immune defense against pathogen infection in plants. |
| first_indexed | 2024-12-21T15:26:02Z |
| format | Article |
| id | doaj.art-bf4b060567a2421f9e8abec991e46e4c |
| institution | Directory Open Access Journal |
| issn | 1177-9322 |
| language | English |
| last_indexed | 2024-12-21T15:26:02Z |
| publishDate | 2014-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Bioinformatics and Biology Insights |
| spelling | doaj.art-bf4b060567a2421f9e8abec991e46e4c2022-12-21T18:58:54ZengSAGE PublishingBioinformatics and Biology Insights1177-93222014-01-01810.4137/BBI.S13462Probing the Unknowns in Cytokinin-Mediated Immune Defense in with Systems Biology ApproachesMuhammad Naseem0Meik Kunz1Thomas Dandekar2These authors have equally contributed to this work.These authors have equally contributed to this work.Functional Genomics and Systems Biology Group, Department of Bioinformatics, Biocenter, WÜrzburg, Germany.Plant hormones involving salicylic acid (SA), jasmonic acid (JA), ethylene (Et), and auxin, gibberellins, and abscisic acid (ABA) are known to regulate host immune responses. However, plant hormone cytokinin has the potential to modulate defense signaling including SA and JA. It promotes plant pathogen and herbivore resistance; underlying mechanisms are still unknown. Using systems biology approaches, we unravel hub points of immune interaction mediated by cytokinin signaling in Arabidopsis. High-confidence Arabidopsis protein—protein interactions (PPI) are coupled to changes in cytokinin-mediated gene expression. Nodes of the cellular interactome that are enriched in immune functions also reconstitute sub-networks. Topological analyses and their specific immunological relevance lead to the identification of functional hubs in cellular interactome. We discuss our identified immune hubs in light of an emerging model of cytokinin-mediated immune defense against pathogen infection in plants.https://doi.org/10.4137/BBI.S13462 |
| spellingShingle | Muhammad Naseem Meik Kunz Thomas Dandekar Probing the Unknowns in Cytokinin-Mediated Immune Defense in with Systems Biology Approaches Bioinformatics and Biology Insights |
| title | Probing the Unknowns in Cytokinin-Mediated Immune Defense in with Systems Biology Approaches |
| title_full | Probing the Unknowns in Cytokinin-Mediated Immune Defense in with Systems Biology Approaches |
| title_fullStr | Probing the Unknowns in Cytokinin-Mediated Immune Defense in with Systems Biology Approaches |
| title_full_unstemmed | Probing the Unknowns in Cytokinin-Mediated Immune Defense in with Systems Biology Approaches |
| title_short | Probing the Unknowns in Cytokinin-Mediated Immune Defense in with Systems Biology Approaches |
| title_sort | probing the unknowns in cytokinin mediated immune defense in with systems biology approaches |
| url | https://doi.org/10.4137/BBI.S13462 |
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