Photoactivatable Platinum-Based Anticancer Drugs: Mode of Photoactivation and Mechanism of Action
Platinum-based anticancer drugs are a class of widely used agents in clinical cancer treatment. However, their efficacy was greatly limited by their severe side effects and the arising drug resistance. The selective activation of inert platinum-based drugs in the tumor site by light irradiation is a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/21/5167 |
| _version_ | 1797548700885581824 |
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| author | Ziwen Dai Zhigang Wang |
| author_facet | Ziwen Dai Zhigang Wang |
| author_sort | Ziwen Dai |
| collection | DOAJ |
| description | Platinum-based anticancer drugs are a class of widely used agents in clinical cancer treatment. However, their efficacy was greatly limited by their severe side effects and the arising drug resistance. The selective activation of inert platinum-based drugs in the tumor site by light irradiation is able to reduce side effects, and the novel mechanism of action of photoactivatable platinum drugs might also conquer the resistance. In this review, the recent advances in the design of photoactivatable platinum-based drugs were summarized. The complexes are classified according to their mode of action, including photoreduction, photo-uncaging, and photodissociation. The rationale of drug design, dark stability, photoactivation process, cytotoxicity, and mechanism of action of typical photoactivatable platinum drugs were reviewed. Finally, the challenges and opportunities for designing more potent photoactivatable platinum drugs were discussed. |
| first_indexed | 2024-03-10T15:03:23Z |
| format | Article |
| id | doaj.art-bf4b7dca97694bf2937706426c13cdd3 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T15:03:23Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-bf4b7dca97694bf2937706426c13cdd32023-11-20T19:59:16ZengMDPI AGMolecules1420-30492020-11-012521516710.3390/molecules25215167Photoactivatable Platinum-Based Anticancer Drugs: Mode of Photoactivation and Mechanism of ActionZiwen Dai0Zhigang Wang1School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen 518055, ChinaSchool of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen 518055, ChinaPlatinum-based anticancer drugs are a class of widely used agents in clinical cancer treatment. However, their efficacy was greatly limited by their severe side effects and the arising drug resistance. The selective activation of inert platinum-based drugs in the tumor site by light irradiation is able to reduce side effects, and the novel mechanism of action of photoactivatable platinum drugs might also conquer the resistance. In this review, the recent advances in the design of photoactivatable platinum-based drugs were summarized. The complexes are classified according to their mode of action, including photoreduction, photo-uncaging, and photodissociation. The rationale of drug design, dark stability, photoactivation process, cytotoxicity, and mechanism of action of typical photoactivatable platinum drugs were reviewed. Finally, the challenges and opportunities for designing more potent photoactivatable platinum drugs were discussed.https://www.mdpi.com/1420-3049/25/21/5167anticancerphotoactivatable platinum drugsphotoactivate chemotherapyprodrugs |
| spellingShingle | Ziwen Dai Zhigang Wang Photoactivatable Platinum-Based Anticancer Drugs: Mode of Photoactivation and Mechanism of Action Molecules anticancer photoactivatable platinum drugs photoactivate chemotherapy prodrugs |
| title | Photoactivatable Platinum-Based Anticancer Drugs: Mode of Photoactivation and Mechanism of Action |
| title_full | Photoactivatable Platinum-Based Anticancer Drugs: Mode of Photoactivation and Mechanism of Action |
| title_fullStr | Photoactivatable Platinum-Based Anticancer Drugs: Mode of Photoactivation and Mechanism of Action |
| title_full_unstemmed | Photoactivatable Platinum-Based Anticancer Drugs: Mode of Photoactivation and Mechanism of Action |
| title_short | Photoactivatable Platinum-Based Anticancer Drugs: Mode of Photoactivation and Mechanism of Action |
| title_sort | photoactivatable platinum based anticancer drugs mode of photoactivation and mechanism of action |
| topic | anticancer photoactivatable platinum drugs photoactivate chemotherapy prodrugs |
| url | https://www.mdpi.com/1420-3049/25/21/5167 |
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