A high-throughput study of visceral organs in CT-scanned pigs
Abstract It has been debated whether intensive selection for growth and carcass yield in pig breeding programmes can affect the size of internal organs, and thereby reduce the animal’s ability to handle stress and increase the risk of sudden deaths. To explore the respiratory and circulatory system...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-13253-7 |
| _version_ | 1811243148005867520 |
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| author | Øyvind Nordbø Rune Sagevik Jørgen Kongsro Kevin Mikkelsen Arne B. Gjuvsland Ann-Helen Gaustad Dan Olsen Espen W. Remme Eli Grindflek |
| author_facet | Øyvind Nordbø Rune Sagevik Jørgen Kongsro Kevin Mikkelsen Arne B. Gjuvsland Ann-Helen Gaustad Dan Olsen Espen W. Remme Eli Grindflek |
| author_sort | Øyvind Nordbø |
| collection | DOAJ |
| description | Abstract It has been debated whether intensive selection for growth and carcass yield in pig breeding programmes can affect the size of internal organs, and thereby reduce the animal’s ability to handle stress and increase the risk of sudden deaths. To explore the respiratory and circulatory system in pigs, a deep learning based computational pipeline was built to extract the size of lungs and hearts from CT-scan images. This pipeline was applied on CT images from 11,000 boar selection candidates acquired during the last decade. Further, heart and lung volumes were analysed genetically and correlated with production traits. Both heart and lung volumes were heritable, with h2 estimated to 0.35 and 0.34, respectively, in Landrace, and 0.28 and 0.4 in Duroc. Both volumes were positively correlated with lean meat percentage, and lung volume was negatively genetically correlated with growth (r g = − 0.48 ± 0.07 for Landrace and r g = − 0.44 ± 0.07 for Duroc). The main findings suggest that the current pig breeding programs could, as an indirect response to selection, affect the size of hearts- and lungs. The presented methods can be used to monitor the development of internal organs in the future. |
| first_indexed | 2024-04-12T14:02:27Z |
| format | Article |
| id | doaj.art-bf4c3213f0874996b8290294e195fd28 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T14:02:27Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-bf4c3213f0874996b8290294e195fd282022-12-22T03:30:10ZengNature PortfolioScientific Reports2045-23222022-06-011211810.1038/s41598-022-13253-7A high-throughput study of visceral organs in CT-scanned pigsØyvind Nordbø0Rune Sagevik1Jørgen Kongsro2Kevin Mikkelsen3Arne B. Gjuvsland4Ann-Helen Gaustad5Dan Olsen6Espen W. Remme7Eli Grindflek8Norsvin SANorsvin SANorsvin SANorsvin SANorsvin SANorsvin SANorsvin SAThe Intervention Centre and Institute for Surgical Research, Oslo University HospitalNorsvin SAAbstract It has been debated whether intensive selection for growth and carcass yield in pig breeding programmes can affect the size of internal organs, and thereby reduce the animal’s ability to handle stress and increase the risk of sudden deaths. To explore the respiratory and circulatory system in pigs, a deep learning based computational pipeline was built to extract the size of lungs and hearts from CT-scan images. This pipeline was applied on CT images from 11,000 boar selection candidates acquired during the last decade. Further, heart and lung volumes were analysed genetically and correlated with production traits. Both heart and lung volumes were heritable, with h2 estimated to 0.35 and 0.34, respectively, in Landrace, and 0.28 and 0.4 in Duroc. Both volumes were positively correlated with lean meat percentage, and lung volume was negatively genetically correlated with growth (r g = − 0.48 ± 0.07 for Landrace and r g = − 0.44 ± 0.07 for Duroc). The main findings suggest that the current pig breeding programs could, as an indirect response to selection, affect the size of hearts- and lungs. The presented methods can be used to monitor the development of internal organs in the future.https://doi.org/10.1038/s41598-022-13253-7 |
| spellingShingle | Øyvind Nordbø Rune Sagevik Jørgen Kongsro Kevin Mikkelsen Arne B. Gjuvsland Ann-Helen Gaustad Dan Olsen Espen W. Remme Eli Grindflek A high-throughput study of visceral organs in CT-scanned pigs Scientific Reports |
| title | A high-throughput study of visceral organs in CT-scanned pigs |
| title_full | A high-throughput study of visceral organs in CT-scanned pigs |
| title_fullStr | A high-throughput study of visceral organs in CT-scanned pigs |
| title_full_unstemmed | A high-throughput study of visceral organs in CT-scanned pigs |
| title_short | A high-throughput study of visceral organs in CT-scanned pigs |
| title_sort | high throughput study of visceral organs in ct scanned pigs |
| url | https://doi.org/10.1038/s41598-022-13253-7 |
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