Epidemiology, risk profile, management, and outcome in geriatric patients with atrial fibrillation in two long-term care hospitals
Abstract Aim of this study was investigate the prevalence and incidence of atrial fibrillation (AF) and to describe the clinical characteristics, risk profiles, and types of anticoagulant therapy for stroke prevention and the clinical outcomes in persons admitted to a long-term care hospital. We con...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-22013-6 |
| _version_ | 1811223545442729984 |
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| author | Gernot Wagner Michael Smeikal Christoph Gisinger Deddo Moertl Stephan Nopp Gerald Gartlehner Ingrid Pabinger Gerald Ohrenberger Cihan Ay |
| author_facet | Gernot Wagner Michael Smeikal Christoph Gisinger Deddo Moertl Stephan Nopp Gerald Gartlehner Ingrid Pabinger Gerald Ohrenberger Cihan Ay |
| author_sort | Gernot Wagner |
| collection | DOAJ |
| description | Abstract Aim of this study was investigate the prevalence and incidence of atrial fibrillation (AF) and to describe the clinical characteristics, risk profiles, and types of anticoagulant therapy for stroke prevention and the clinical outcomes in persons admitted to a long-term care hospital. We conducted a retrospective cohort study using data from the electronic medical records of patients aged 65 years or older living in two long-term care hospitals between January 1, 2014 and October 31, 2017. Overall data from 1148 patients (mean age 84.1 ± 7.9 years, 74.2% women) were analyzed. At baseline, the median CHA2DS2-VASc score was 4 (IQR 3–5) and the HAS-BLED score 2 (IQR 2–3). We observed patients over a median period of 3.7 years. The point prevalence of AF was 29.6% (95% CI 25.8–33.7) on January 1, 2014. The 1-year cumulative incidence of de novo AF was 4.0% (2.8–5.6). Oral anticoagulants were prescribed in 48% of patients with AF. The cumulative incidence at 1 year for a composite outcome of TIA, stroke, or systemic arterial embolism was 0.6% (0.1–3.1) and 1.7% (0.5–4.6) and for bleeding 2.6% (0.9–6.2) and 1.8% (0.5–4.8) in patients with AF and oral anticoagulants or no oral anticoagulants, respectively. In long-term care hospital patients, we observed a high burden of AF. However, only about half of patients with AF received oral anticoagulation for stroke prevention. |
| first_indexed | 2024-04-12T08:34:26Z |
| format | Article |
| id | doaj.art-bf4d290c847a45b0b68f1d6a7765fe01 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T08:34:26Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-bf4d290c847a45b0b68f1d6a7765fe012022-12-22T03:40:04ZengNature PortfolioScientific Reports2045-23222022-11-011211910.1038/s41598-022-22013-6Epidemiology, risk profile, management, and outcome in geriatric patients with atrial fibrillation in two long-term care hospitalsGernot Wagner0Michael Smeikal1Christoph Gisinger2Deddo Moertl3Stephan Nopp4Gerald Gartlehner5Ingrid Pabinger6Gerald Ohrenberger7Cihan Ay8Department for Evidence-based Medicine and Evaluation, Danube University KremsHaus der Barmherzigkeit TokiostraßeHaus der Barmherzigkeit TokiostraßeDepartment of Internal Medicine 3, University Hospital St. PoeltenClinical Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of ViennaDepartment for Evidence-based Medicine and Evaluation, Danube University KremsClinical Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of ViennaHaus der Barmherzigkeit SeeboeckgasseClinical Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of ViennaAbstract Aim of this study was investigate the prevalence and incidence of atrial fibrillation (AF) and to describe the clinical characteristics, risk profiles, and types of anticoagulant therapy for stroke prevention and the clinical outcomes in persons admitted to a long-term care hospital. We conducted a retrospective cohort study using data from the electronic medical records of patients aged 65 years or older living in two long-term care hospitals between January 1, 2014 and October 31, 2017. Overall data from 1148 patients (mean age 84.1 ± 7.9 years, 74.2% women) were analyzed. At baseline, the median CHA2DS2-VASc score was 4 (IQR 3–5) and the HAS-BLED score 2 (IQR 2–3). We observed patients over a median period of 3.7 years. The point prevalence of AF was 29.6% (95% CI 25.8–33.7) on January 1, 2014. The 1-year cumulative incidence of de novo AF was 4.0% (2.8–5.6). Oral anticoagulants were prescribed in 48% of patients with AF. The cumulative incidence at 1 year for a composite outcome of TIA, stroke, or systemic arterial embolism was 0.6% (0.1–3.1) and 1.7% (0.5–4.6) and for bleeding 2.6% (0.9–6.2) and 1.8% (0.5–4.8) in patients with AF and oral anticoagulants or no oral anticoagulants, respectively. In long-term care hospital patients, we observed a high burden of AF. However, only about half of patients with AF received oral anticoagulation for stroke prevention.https://doi.org/10.1038/s41598-022-22013-6 |
| spellingShingle | Gernot Wagner Michael Smeikal Christoph Gisinger Deddo Moertl Stephan Nopp Gerald Gartlehner Ingrid Pabinger Gerald Ohrenberger Cihan Ay Epidemiology, risk profile, management, and outcome in geriatric patients with atrial fibrillation in two long-term care hospitals Scientific Reports |
| title | Epidemiology, risk profile, management, and outcome in geriatric patients with atrial fibrillation in two long-term care hospitals |
| title_full | Epidemiology, risk profile, management, and outcome in geriatric patients with atrial fibrillation in two long-term care hospitals |
| title_fullStr | Epidemiology, risk profile, management, and outcome in geriatric patients with atrial fibrillation in two long-term care hospitals |
| title_full_unstemmed | Epidemiology, risk profile, management, and outcome in geriatric patients with atrial fibrillation in two long-term care hospitals |
| title_short | Epidemiology, risk profile, management, and outcome in geriatric patients with atrial fibrillation in two long-term care hospitals |
| title_sort | epidemiology risk profile management and outcome in geriatric patients with atrial fibrillation in two long term care hospitals |
| url | https://doi.org/10.1038/s41598-022-22013-6 |
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