Efficacy and safety of cryoballoon ablation versus radiofrequency catheter ablation in atrial fibrillation: an updated meta-analysis
Introduction: Cryoballoon ablation (CBA) and irrigated radiofrequency catheter ablation (RFCA) are the main treatments for drug-refractory symptomatic atrial fibrillation (AF). Aim: To compare the efficacy and safety between CBA and RFCA for the treatment of AF. Material and methods : We sea...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2017-09-01
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| Series: | Advances in Interventional Cardiology |
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| Online Access: | https://www.termedia.pl/Efficacy-and-safety-of-cryoballoon-ablation-versus-radiofrequency-catheter-ablation-in-atrial-fibrillation-an-updated-meta-analysis,35,30621,1,1.html |
| _version_ | 1819057900316786688 |
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| author | Honglan Ma Dongdong Sun Hui Luan Wei Feng Yaqiong Zhou Jine Wu Caiyun He Chaofeng Sun |
| author_facet | Honglan Ma Dongdong Sun Hui Luan Wei Feng Yaqiong Zhou Jine Wu Caiyun He Chaofeng Sun |
| author_sort | Honglan Ma |
| collection | DOAJ |
| description | Introduction: Cryoballoon ablation (CBA) and irrigated radiofrequency catheter ablation (RFCA) are the main treatments for drug-refractory symptomatic atrial fibrillation (AF).
Aim: To compare the efficacy and safety between CBA and RFCA for the treatment of AF.
Material and methods : We searched the Embase and Medline databases for clinical studies published up to December 2016. Studies that satisfied our predefined inclusion criteria were included.
Results : After searching through the literature in the two major databases, 20 studies with a total of 9,141 patients were included in our study. The CBA had a significantly shorter procedure time (weighted mean difference (WMD) –30.38 min; 95% CI: –46.43 to –14.33, p = 0.0002) and non-significantly shorter fluoroscopy time (WMD –3.18 min; 95% CI: –6.43 to 0.07, p = 0.06) compared with RFCA. There was no difference in freedom from AF between CBA and RFCA (CBA 78.55% vs. RFCA 83.13%, OR = 1.15, 95% CI: 0.95–1.39, p = 0.14). The CBA was associated with a high risk of procedure-related complications (CBA 9.02% vs. RFCA 6.56%, OR = 1.56, 95% CI: 1.05–2.31, p = 0.03), especially phrenic nerve paralysis (PNP, OR = 10.72, 95% CI: 5.59–20.55, p < 0.00001). The risk of pericardial effusions/cardiac tamponade was low in the CBA group (CBA 1.05% vs. RFCA 1.86%, OR = 0.62, 95% CI: 0.41–0.93, p = 0.02).
Conclusions : For AF, CBA was as effective as RFCA. However, CBA had a shorter procedure time and a non-significantly shorter fluoroscopy time, a significantly high risk of PNP and a low incidence of pericardial effusions/cardiac tamponade compared with RFCA. |
| first_indexed | 2024-12-21T13:46:39Z |
| format | Article |
| id | doaj.art-bf4ecff1f7fa4472afd318888192ee84 |
| institution | Directory Open Access Journal |
| issn | 1734-9338 1897-4295 |
| language | English |
| last_indexed | 2024-12-21T13:46:39Z |
| publishDate | 2017-09-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Advances in Interventional Cardiology |
| spelling | doaj.art-bf4ecff1f7fa4472afd318888192ee842022-12-21T19:01:52ZengTermedia Publishing HouseAdvances in Interventional Cardiology1734-93381897-42952017-09-0113324024910.5114/aic.2017.7019630621Efficacy and safety of cryoballoon ablation versus radiofrequency catheter ablation in atrial fibrillation: an updated meta-analysisHonglan MaDongdong SunHui LuanWei FengYaqiong ZhouJine WuCaiyun HeChaofeng SunIntroduction: Cryoballoon ablation (CBA) and irrigated radiofrequency catheter ablation (RFCA) are the main treatments for drug-refractory symptomatic atrial fibrillation (AF). Aim: To compare the efficacy and safety between CBA and RFCA for the treatment of AF. Material and methods : We searched the Embase and Medline databases for clinical studies published up to December 2016. Studies that satisfied our predefined inclusion criteria were included. Results : After searching through the literature in the two major databases, 20 studies with a total of 9,141 patients were included in our study. The CBA had a significantly shorter procedure time (weighted mean difference (WMD) –30.38 min; 95% CI: –46.43 to –14.33, p = 0.0002) and non-significantly shorter fluoroscopy time (WMD –3.18 min; 95% CI: –6.43 to 0.07, p = 0.06) compared with RFCA. There was no difference in freedom from AF between CBA and RFCA (CBA 78.55% vs. RFCA 83.13%, OR = 1.15, 95% CI: 0.95–1.39, p = 0.14). The CBA was associated with a high risk of procedure-related complications (CBA 9.02% vs. RFCA 6.56%, OR = 1.56, 95% CI: 1.05–2.31, p = 0.03), especially phrenic nerve paralysis (PNP, OR = 10.72, 95% CI: 5.59–20.55, p < 0.00001). The risk of pericardial effusions/cardiac tamponade was low in the CBA group (CBA 1.05% vs. RFCA 1.86%, OR = 0.62, 95% CI: 0.41–0.93, p = 0.02). Conclusions : For AF, CBA was as effective as RFCA. However, CBA had a shorter procedure time and a non-significantly shorter fluoroscopy time, a significantly high risk of PNP and a low incidence of pericardial effusions/cardiac tamponade compared with RFCA.https://www.termedia.pl/Efficacy-and-safety-of-cryoballoon-ablation-versus-radiofrequency-catheter-ablation-in-atrial-fibrillation-an-updated-meta-analysis,35,30621,1,1.htmlcryoballoon ablation radiofrequency catheter ablation atrial fibrillation meta-analysis |
| spellingShingle | Honglan Ma Dongdong Sun Hui Luan Wei Feng Yaqiong Zhou Jine Wu Caiyun He Chaofeng Sun Efficacy and safety of cryoballoon ablation versus radiofrequency catheter ablation in atrial fibrillation: an updated meta-analysis Advances in Interventional Cardiology cryoballoon ablation radiofrequency catheter ablation atrial fibrillation meta-analysis |
| title | Efficacy and safety of cryoballoon ablation versus radiofrequency catheter ablation in atrial fibrillation: an updated meta-analysis |
| title_full | Efficacy and safety of cryoballoon ablation versus radiofrequency catheter ablation in atrial fibrillation: an updated meta-analysis |
| title_fullStr | Efficacy and safety of cryoballoon ablation versus radiofrequency catheter ablation in atrial fibrillation: an updated meta-analysis |
| title_full_unstemmed | Efficacy and safety of cryoballoon ablation versus radiofrequency catheter ablation in atrial fibrillation: an updated meta-analysis |
| title_short | Efficacy and safety of cryoballoon ablation versus radiofrequency catheter ablation in atrial fibrillation: an updated meta-analysis |
| title_sort | efficacy and safety of cryoballoon ablation versus radiofrequency catheter ablation in atrial fibrillation an updated meta analysis |
| topic | cryoballoon ablation radiofrequency catheter ablation atrial fibrillation meta-analysis |
| url | https://www.termedia.pl/Efficacy-and-safety-of-cryoballoon-ablation-versus-radiofrequency-catheter-ablation-in-atrial-fibrillation-an-updated-meta-analysis,35,30621,1,1.html |
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