WASP family proteins: Molecular mechanisms and implications in human disease
Proteins of the Wiskott-Aldrich syndrome protein (WASP) family play a central role in regulating actin cytoskeletal dynamics in a wide range of cellular processes. Genetic mutations or misregulation of these proteins are tightly associated with many diseases. The WASP-family proteins act by transmit...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | European Journal of Cell Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0171933522000474 |
| _version_ | 1818172854314729472 |
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| author | Daniel A. Kramer Hannah K. Piper Baoyu Chen |
| author_facet | Daniel A. Kramer Hannah K. Piper Baoyu Chen |
| author_sort | Daniel A. Kramer |
| collection | DOAJ |
| description | Proteins of the Wiskott-Aldrich syndrome protein (WASP) family play a central role in regulating actin cytoskeletal dynamics in a wide range of cellular processes. Genetic mutations or misregulation of these proteins are tightly associated with many diseases. The WASP-family proteins act by transmitting various upstream signals to their conserved WH2-Central-Acidic (WCA) peptide sequence at the C-terminus, which in turn binds to the Arp2/3 complex to stimulate the formation of branched actin networks at membranes. Despite this common feature, the regulatory mechanisms and cellular functions of distinct WASP-family proteins are very different. Here, we summarize and clarify our current understanding of WASP-family proteins and how disruption of their functions is related to human disease. |
| first_indexed | 2024-12-11T19:19:13Z |
| format | Article |
| id | doaj.art-bf50c8c566e0464dad2d2c136dade40c |
| institution | Directory Open Access Journal |
| issn | 0171-9335 |
| language | English |
| last_indexed | 2024-12-11T19:19:13Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Cell Biology |
| spelling | doaj.art-bf50c8c566e0464dad2d2c136dade40c2022-12-22T00:53:34ZengElsevierEuropean Journal of Cell Biology0171-93352022-06-011013151244WASP family proteins: Molecular mechanisms and implications in human diseaseDaniel A. Kramer0Hannah K. Piper1Baoyu Chen2Roy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University, 2437 Pammel Drive, Ames, IA 50011, USARoy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University, 2437 Pammel Drive, Ames, IA 50011, USACorresponding author.; Roy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University, 2437 Pammel Drive, Ames, IA 50011, USAProteins of the Wiskott-Aldrich syndrome protein (WASP) family play a central role in regulating actin cytoskeletal dynamics in a wide range of cellular processes. Genetic mutations or misregulation of these proteins are tightly associated with many diseases. The WASP-family proteins act by transmitting various upstream signals to their conserved WH2-Central-Acidic (WCA) peptide sequence at the C-terminus, which in turn binds to the Arp2/3 complex to stimulate the formation of branched actin networks at membranes. Despite this common feature, the regulatory mechanisms and cellular functions of distinct WASP-family proteins are very different. Here, we summarize and clarify our current understanding of WASP-family proteins and how disruption of their functions is related to human disease.http://www.sciencedirect.com/science/article/pii/S0171933522000474Wiskott-Aldrich syndromeWASPWAVEWRCWASHSHRC |
| spellingShingle | Daniel A. Kramer Hannah K. Piper Baoyu Chen WASP family proteins: Molecular mechanisms and implications in human disease European Journal of Cell Biology Wiskott-Aldrich syndrome WASP WAVE WRC WASH SHRC |
| title | WASP family proteins: Molecular mechanisms and implications in human disease |
| title_full | WASP family proteins: Molecular mechanisms and implications in human disease |
| title_fullStr | WASP family proteins: Molecular mechanisms and implications in human disease |
| title_full_unstemmed | WASP family proteins: Molecular mechanisms and implications in human disease |
| title_short | WASP family proteins: Molecular mechanisms and implications in human disease |
| title_sort | wasp family proteins molecular mechanisms and implications in human disease |
| topic | Wiskott-Aldrich syndrome WASP WAVE WRC WASH SHRC |
| url | http://www.sciencedirect.com/science/article/pii/S0171933522000474 |
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