WASP family proteins: Molecular mechanisms and implications in human disease

WASP family proteins: Molecular mechanisms and implications in human disease

Proteins of the Wiskott-Aldrich syndrome protein (WASP) family play a central role in regulating actin cytoskeletal dynamics in a wide range of cellular processes. Genetic mutations or misregulation of these proteins are tightly associated with many diseases. The WASP-family proteins act by transmit...

Full description

Bibliographic Details
Main Authors:	Daniel A. Kramer, Hannah K. Piper, Baoyu Chen
Format:	Article
Language:	English
Published:	Elsevier 2022-06-01
Series:	European Journal of Cell Biology
Subjects:	Wiskott-Aldrich syndrome WASP WAVE WRC WASH SHRC
Online Access:	http://www.sciencedirect.com/science/article/pii/S0171933522000474

Similar Items

Intermittent low platelet counts hampering diagnosis of X-linked thrombocytopenia in children: report of two unrelated cases and a novel mutation in the gene coding for the Wiskott-Aldrich syndrome protein
by: Samuel Souza Medina, et al.
Published: (2017-06-01)

FLI1 Induces Megakaryopoiesis Gene Expression Through WAS/WIP-Dependent and Independent Mechanisms; Implications for Wiskott-Aldrich Syndrome
by: Chunlin Wang, et al.
Published: (2021-02-01)

Detection of Six Novel Mutations in WASP Gene in Fifteen Iranian Wiskott-Aldrich Patients
by: Sepideh Safaei, et al.
Published: (2012-12-01)

Wiskott-Aldrich syndrome mutation in two Turkish siblings with X-linked thrombocytopenia
by: Göksel Leblebisatan, et al.
Published: (2011-06-01)

Wiskott-Aldrich syndrome mutation in two Turkish siblings with X-linked thrombocytopenia
by: Göksel Leblebisatan, et al.
Published: (2011-05-01)

Recent Advances of the Wiskott-aldrich Syndrome Protein Family Members in Tumorigenesis and Progression
by: Xin XIE, Yan CHEN, Zhixu HE, Pei HUANG, Qinghua CHEN
Published: (2022-05-01)

Confirmed diagnosis of classic Wiskott–Aldrich syndrome in East Africa: a case report
by: Mpokigwa Kiputa, et al.
Published: (2022-07-01)

Wiskott-Aldrich Syndrome With Normal-Sized Platelets in an Eighteen-Month-Old Boy: A Rare Mutation
by: Jayitri Mazumdar, et al.
Published: (2015-07-01)

Fatal Cytomegalovirus Gastrointestinal Disease in an Infant with Wiskott-Aldrich Syndrome
by: Kuan-Ying Huang, et al.
Published: (2008-01-01)

Wiskott-Aldrich Syndrome; An X-Linked Primary Immunodeficiency Disease with Unique and Characteristic Features
by: Tadashi Ariga
Published: (2012-01-01)

Nuclear Wiskott–Aldrich syndrome protein co-regulates T cell factor 1-mediated transcription in T cells
by: Nikolai V. Kuznetsov, et al.
Published: (2017-10-01)

A Novel Mutation in a Patient with Wiskott-Aldrich Syndrome
by: Yurday Öncül, et al.
Published: (2020-05-01)

Analysis of clinical and molecular genetic characteristics of Wiskott-Aldrich syndrome and X-linked thrombocytopenia
by: Doina TURCAN, et al.
Published: (2021-06-01)

WASp Is Essential for Effector-to-Memory conversion and for Maintenance of CD8+T Cell Memory
by: Qiao Liu, et al.
Published: (2019-09-01)

A Novel Mutation in a Child with Atypical Wiskott-Aldrich Syndrome Complicated by Cytomegalovirus Infection
by: Zühre Kaya, et al.
Published: (2019-02-01)

Resistant Widespread Facial Impetigo in a Healthy Infant with Atopic Dermatitis
by: Seyed Hesamedin Nabavizadeh, et al.
Published: (2018-03-01)

Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector
by: Swati Singh, et al.
Published: (2017-03-01)

Prolonged survival after splenectomy in Wiskott-Aldrich syndrome: a case report
by: Tsimpoukis Sotirios, et al.
Published: (2011-09-01)

Actin Remodeling Defects Leading to Autoinflammation and Immune Dysregulation
by: Riccardo Papa, et al.
Published: (2021-01-01)

Identification of a novel WAS mutation in a South African patient presenting with atypical Wiskott-Aldrich syndrome: a case report
by: Brigitte Glanzmann, et al.
Published: (2020-06-01)

Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation
by: Benjamin A Smith, et al.
Published: (2013-09-01)

Unravelling the repertoire in Wiskott-Aldrich syndrome
by: Sven H. Petersen, et al.
Published: (2014-10-01)

Evolution of the eukaryotic ARP2/3 activators of the WASP family: WASP, WAVE, WASH, and WHAMM, and the proposed new family members WAWH and WAML
by: Kollmar Martin, et al.
Published: (2012-02-01)

Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells
by: Elizabeth Rivers, et al.
Published: (2020-11-01)

Yeast as a Model to Understand Actin-Mediated Cellular Functions in Mammals—Illustrated with Four Actin Cytoskeleton Proteins
by: Zain Akram, et al.
Published: (2020-03-01)

Allogeneic hematopoietic stem cell transplantation outcome in oldest known surviving patients with Wiskott-Aldrich syndrome
by: Ariharan Anantharachagan, MBChB, MRCP, MsC,FRCPath, et al.
Published: (2024-02-01)

Clinical Features and Outcomes of 23 Patients with Wiskott- Aldrich Syndrome: A Single-Center Experience
by: Şule Haskoloğlu, et al.
Published: (2020-11-01)

Autoimmunity in Wiskott-Aldrich Syndrome: an unsolved enigma
by: Marco eCatucci, et al.
Published: (2012-07-01)

Wiskott-Aldrich Syndrome (WAS) and Dedicator of Cytokinesis 8- (DOCK8) Deficiency
by: Michael H. Albert, et al.
Published: (2019-11-01)

WASp Deficiency Selectively Affects the TCR Diversity of Different Memory T Cell Subsets in WAS Chimeric Mice
by: Wenyan Li, et al.
Published: (2022-01-01)

Evolutionary rescue by compensatory mutations is constrained by genomic and environmental backgrounds
by: Marie Filteau, et al.
Published: (2015-10-01)

Identification of a novel WAS mutation and the non-splicing effect of a second-site mutation in a Chinese pedigree with Wiskott–Aldrich syndrome
by: Xin Ji, et al.
Published: (2022-12-01)

Signal integration during T lymphocyte activation and function: lessons from the Wiskott-Aldrich syndrome
by: Vinícius eCotta-de-Almeida, et al.
Published: (2015-02-01)

Wiskott-Aldrich Syndrome. A Report of a New Mutation
by: Nelva Lizbeth Guillén-Rocha, et al.
Published: (2014-06-01)

WAS Promoter-Driven Lentiviral Vectors Mimic Closely the Lopsided WASP Expression during Megakaryocytic Differentiation
by: Pilar Muñoz, et al.
Published: (2020-12-01)

The Wiskott–Aldrich syndrome protein is required for positive selection during T-cell lineage differentiation
by: Melissa Pille, et al.
Published: (2023-06-01)

Gene editing-based targeted integration for correction of Wiskott-Aldrich syndrome
by: Melissa Pille, et al.
Published: (2024-03-01)

Next generation sequencing reveals skewing of the T and B cell receptor repertoires in patients with Wiskott Aldrich syndrome
by: Amy E O'Connell, et al.
Published: (2014-07-01)

A novel splice site mutation in WAS gene in patient with Wiskott-Aldrich syndrome and chronic colitis: a case report
by: Hossein Esmaeilzadeh, et al.
Published: (2018-07-01)

Case Report: Wiskott-Aldrich Syndrome Caused by Extremely Skewed X-Chromosome Inactivation in a Chinese Girl
by: Xuening Hou, et al.
Published: (2021-07-01)