Modulating cholesterol-rich lipid rafts to disrupt influenza A virus infection
Influenza A virus (IAV) is widely disseminated across different species and can cause recurrent epidemics and severe pandemics in humans. During infection, IAV attaches to receptors that are predominantly located in cell membrane regions known as lipid rafts, which are highly enriched in cholesterol...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-09-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.982264/full |
| _version_ | 1828232314704887808 |
|---|---|
| author | Yu-Jyun Li Yu-Jyun Li Chi-Yuan Chen Jeng-How Yang Ya-Fang Chiu Ya-Fang Chiu Ya-Fang Chiu Ya-Fang Chiu |
| author_facet | Yu-Jyun Li Yu-Jyun Li Chi-Yuan Chen Jeng-How Yang Ya-Fang Chiu Ya-Fang Chiu Ya-Fang Chiu Ya-Fang Chiu |
| author_sort | Yu-Jyun Li |
| collection | DOAJ |
| description | Influenza A virus (IAV) is widely disseminated across different species and can cause recurrent epidemics and severe pandemics in humans. During infection, IAV attaches to receptors that are predominantly located in cell membrane regions known as lipid rafts, which are highly enriched in cholesterol and sphingolipids. Following IAV entry into the host cell, uncoating, transcription, and replication of the viral genome occur, after which newly synthesized viral proteins and genomes are delivered to lipid rafts for assembly prior to viral budding from the cell. Moreover, during budding, IAV acquires an envelope with embedded cholesterol from the host cell membrane, and it is known that decreased cholesterol levels on IAV virions reduce infectivity. Statins are commonly used to inhibit cholesterol synthesis for preventing cardiovascular diseases, and several studies have investigated whether such inhibition can block IAV infection and propagation, as well as modulate the host immune response to IAV. Taken together, current research suggests that there may be a role for statins in countering IAV infections and modulating the host immune response to prevent or mitigate cytokine storms, and further investigation into this is warranted. |
| first_indexed | 2024-04-12T19:20:52Z |
| format | Article |
| id | doaj.art-bf524eef574e478caf3390c5e2447e02 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T19:20:52Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-bf524eef574e478caf3390c5e2447e022022-12-22T03:19:37ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-09-011310.3389/fimmu.2022.982264982264Modulating cholesterol-rich lipid rafts to disrupt influenza A virus infectionYu-Jyun Li0Yu-Jyun Li1Chi-Yuan Chen2Jeng-How Yang3Ya-Fang Chiu4Ya-Fang Chiu5Ya-Fang Chiu6Ya-Fang Chiu7Department of Microbiology and Immunology, Chang Gung University, Taoyuan, TaiwanGraduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan, TaiwanDepartment of Microbiology and Immunology, Chang Gung University, Taoyuan, TaiwanDivision of Infectious Diseases, Department of Medicine, Chang Gung Memorial Hospital, New Taipei, TaiwanDepartment of Microbiology and Immunology, Chang Gung University, Taoyuan, TaiwanGraduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan, TaiwanResearch Center for Emerging Viral Infections, Chang Gung University, Taoyuan, TaiwanDepartment of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, TaiwanInfluenza A virus (IAV) is widely disseminated across different species and can cause recurrent epidemics and severe pandemics in humans. During infection, IAV attaches to receptors that are predominantly located in cell membrane regions known as lipid rafts, which are highly enriched in cholesterol and sphingolipids. Following IAV entry into the host cell, uncoating, transcription, and replication of the viral genome occur, after which newly synthesized viral proteins and genomes are delivered to lipid rafts for assembly prior to viral budding from the cell. Moreover, during budding, IAV acquires an envelope with embedded cholesterol from the host cell membrane, and it is known that decreased cholesterol levels on IAV virions reduce infectivity. Statins are commonly used to inhibit cholesterol synthesis for preventing cardiovascular diseases, and several studies have investigated whether such inhibition can block IAV infection and propagation, as well as modulate the host immune response to IAV. Taken together, current research suggests that there may be a role for statins in countering IAV infections and modulating the host immune response to prevent or mitigate cytokine storms, and further investigation into this is warranted.https://www.frontiersin.org/articles/10.3389/fimmu.2022.982264/fullinfluenza A virusstatinsinflammatory cytokineslipid raftscholesterol |
| spellingShingle | Yu-Jyun Li Yu-Jyun Li Chi-Yuan Chen Jeng-How Yang Ya-Fang Chiu Ya-Fang Chiu Ya-Fang Chiu Ya-Fang Chiu Modulating cholesterol-rich lipid rafts to disrupt influenza A virus infection Frontiers in Immunology influenza A virus statins inflammatory cytokines lipid rafts cholesterol |
| title | Modulating cholesterol-rich lipid rafts to disrupt influenza A virus infection |
| title_full | Modulating cholesterol-rich lipid rafts to disrupt influenza A virus infection |
| title_fullStr | Modulating cholesterol-rich lipid rafts to disrupt influenza A virus infection |
| title_full_unstemmed | Modulating cholesterol-rich lipid rafts to disrupt influenza A virus infection |
| title_short | Modulating cholesterol-rich lipid rafts to disrupt influenza A virus infection |
| title_sort | modulating cholesterol rich lipid rafts to disrupt influenza a virus infection |
| topic | influenza A virus statins inflammatory cytokines lipid rafts cholesterol |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.982264/full |
| work_keys_str_mv | AT yujyunli modulatingcholesterolrichlipidraftstodisruptinfluenzaavirusinfection AT yujyunli modulatingcholesterolrichlipidraftstodisruptinfluenzaavirusinfection AT chiyuanchen modulatingcholesterolrichlipidraftstodisruptinfluenzaavirusinfection AT jenghowyang modulatingcholesterolrichlipidraftstodisruptinfluenzaavirusinfection AT yafangchiu modulatingcholesterolrichlipidraftstodisruptinfluenzaavirusinfection AT yafangchiu modulatingcholesterolrichlipidraftstodisruptinfluenzaavirusinfection AT yafangchiu modulatingcholesterolrichlipidraftstodisruptinfluenzaavirusinfection AT yafangchiu modulatingcholesterolrichlipidraftstodisruptinfluenzaavirusinfection |