Sinoatrial Beat to Beat Variability Assessed by Contraction Strength in Addition to the Interbeat Interval
Beat to beat variability of cardiac tissue or isolated cells is frequently investigated by determining time intervals from electrode measurements in order to compute scale dependent or scale independent parameters. In this study, we utilize high-speed video camera recordings to investigate the varia...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-05-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2018.00546/full |
| _version_ | 1818984953047678976 |
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| author | Helmut Ahammer Susanne Scheruebel Robert Arnold Michael Mayrhofer-Reinhartshuber Michael Mayrhofer-Reinhartshuber Petra Lang Ádám Dolgos Brigitte Pelzmann Klaus Zorn-Pauly |
| author_facet | Helmut Ahammer Susanne Scheruebel Robert Arnold Michael Mayrhofer-Reinhartshuber Michael Mayrhofer-Reinhartshuber Petra Lang Ádám Dolgos Brigitte Pelzmann Klaus Zorn-Pauly |
| author_sort | Helmut Ahammer |
| collection | DOAJ |
| description | Beat to beat variability of cardiac tissue or isolated cells is frequently investigated by determining time intervals from electrode measurements in order to compute scale dependent or scale independent parameters. In this study, we utilize high-speed video camera recordings to investigate the variability of intervals as well as mechanical contraction strengths and relative contraction strengths with nonlinear analyses. Additionally, the video setup allowed us simultaneous electrode registrations of extracellular potentials. Sinoatrial node tissue under control and acetylcholine treated conditions was used to perform variability analyses by computing sample entropies and Higuchi dimensions. Beat to beat interval variabilities measured by the two recording techniques correlated very well, and therefore, validated the video analyses for this purpose. Acetylcholine treatment induced a reduction of beating rate and contraction strength, but the impact on interval variability was negligible. Nevertheless, the variability analyses of contraction strengths revealed significant differences in sample entropies and Higuchi dimensions between control and acetylcholine treated tissue. Therefore, the proposed high-speed video camera technique might represent a non-invasive tool that allows long-lasting recordings for detecting variations in beating behavior over a large range of scales. |
| first_indexed | 2024-12-20T18:27:11Z |
| format | Article |
| id | doaj.art-bf557f2843bd486e88bcf267ae9e83d9 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-20T18:27:11Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-bf557f2843bd486e88bcf267ae9e83d92022-12-21T19:30:07ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-05-01910.3389/fphys.2018.00546364825Sinoatrial Beat to Beat Variability Assessed by Contraction Strength in Addition to the Interbeat IntervalHelmut Ahammer0Susanne Scheruebel1Robert Arnold2Michael Mayrhofer-Reinhartshuber3Michael Mayrhofer-Reinhartshuber4Petra Lang5Ádám Dolgos6Brigitte Pelzmann7Klaus Zorn-Pauly8Institute of Biophysics, Medical University of Graz, Graz, AustriaInstitute of Biophysics, Medical University of Graz, Graz, AustriaInstitute of Biophysics, Medical University of Graz, Graz, AustriaInstitute of Biophysics, Medical University of Graz, Graz, AustriaKML Vision OG, Graz, AustriaInstitute of Biophysics, Medical University of Graz, Graz, AustriaInstitute for eHealth, Graz University of Applied Sciences, Graz, AustriaInstitute of Biophysics, Medical University of Graz, Graz, AustriaInstitute of Biophysics, Medical University of Graz, Graz, AustriaBeat to beat variability of cardiac tissue or isolated cells is frequently investigated by determining time intervals from electrode measurements in order to compute scale dependent or scale independent parameters. In this study, we utilize high-speed video camera recordings to investigate the variability of intervals as well as mechanical contraction strengths and relative contraction strengths with nonlinear analyses. Additionally, the video setup allowed us simultaneous electrode registrations of extracellular potentials. Sinoatrial node tissue under control and acetylcholine treated conditions was used to perform variability analyses by computing sample entropies and Higuchi dimensions. Beat to beat interval variabilities measured by the two recording techniques correlated very well, and therefore, validated the video analyses for this purpose. Acetylcholine treatment induced a reduction of beating rate and contraction strength, but the impact on interval variability was negligible. Nevertheless, the variability analyses of contraction strengths revealed significant differences in sample entropies and Higuchi dimensions between control and acetylcholine treated tissue. Therefore, the proposed high-speed video camera technique might represent a non-invasive tool that allows long-lasting recordings for detecting variations in beating behavior over a large range of scales.https://www.frontiersin.org/article/10.3389/fphys.2018.00546/fullheart rate variabilitybeat to beat variabilityvideo motion analysissinoatrial nodeacetylcholinesample entropy |
| spellingShingle | Helmut Ahammer Susanne Scheruebel Robert Arnold Michael Mayrhofer-Reinhartshuber Michael Mayrhofer-Reinhartshuber Petra Lang Ádám Dolgos Brigitte Pelzmann Klaus Zorn-Pauly Sinoatrial Beat to Beat Variability Assessed by Contraction Strength in Addition to the Interbeat Interval Frontiers in Physiology heart rate variability beat to beat variability video motion analysis sinoatrial node acetylcholine sample entropy |
| title | Sinoatrial Beat to Beat Variability Assessed by Contraction Strength in Addition to the Interbeat Interval |
| title_full | Sinoatrial Beat to Beat Variability Assessed by Contraction Strength in Addition to the Interbeat Interval |
| title_fullStr | Sinoatrial Beat to Beat Variability Assessed by Contraction Strength in Addition to the Interbeat Interval |
| title_full_unstemmed | Sinoatrial Beat to Beat Variability Assessed by Contraction Strength in Addition to the Interbeat Interval |
| title_short | Sinoatrial Beat to Beat Variability Assessed by Contraction Strength in Addition to the Interbeat Interval |
| title_sort | sinoatrial beat to beat variability assessed by contraction strength in addition to the interbeat interval |
| topic | heart rate variability beat to beat variability video motion analysis sinoatrial node acetylcholine sample entropy |
| url | https://www.frontiersin.org/article/10.3389/fphys.2018.00546/full |
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