Comparable Accuracy of Quantitative and Visual Analyses of [<sup>18</sup>F]FDG PET/CT for the Detection of Lymph Node Metastases from Head and Neck Squamous Cell Carcinoma
Background: In head and neck squamous cell carcinoma (HNSCC), [<sup>18</sup>F]FDG PET/CT is recommended for detecting recurrent disease and in the initial staging for evaluating distant metastases, but its use in detecting cervical lymph metastases remains unclear. The aim of this study...
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MDPI AG
2023-08-01
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| author | Philippe d’Abadie Nicolas Michoux Thierry Duprez Sandra Schmitz Michèle Magremanne Pascal Van Eeckhout Olivier Gheysens |
| author_facet | Philippe d’Abadie Nicolas Michoux Thierry Duprez Sandra Schmitz Michèle Magremanne Pascal Van Eeckhout Olivier Gheysens |
| author_sort | Philippe d’Abadie |
| collection | DOAJ |
| description | Background: In head and neck squamous cell carcinoma (HNSCC), [<sup>18</sup>F]FDG PET/CT is recommended for detecting recurrent disease and in the initial staging for evaluating distant metastases, but its use in detecting cervical lymph metastases remains unclear. The aim of this study is to evaluate and compare the diagnostic accuracy of [<sup>8</sup>F]FDG-PET/CT using visual and semi-quantitative analyses for detecting the nodal involvement in HNSCC. Methods: We analyzed consecutive patients who underwent a preoperative [<sup>18</sup>F]FDG-PET/CT and neck dissection for HNSCC at our tertiary hospital. A blinded evaluation of the [<sup>18</sup>F]FDG uptake in each neck level was performed using a semi-quantitative approach (SUVmax and SUVR) and a visual grading system (uptake superior to the internal jugular vein for grade 1 and superior to the liver for grade 2). Analyses were compared to the histological results. Results: In our 211 patients, analyses demonstrated similar diagnostic accuracy using a semi-quantitative approach or a visual grading system. Regarding the visual grading system, [<sup>18</sup>F]FDG-PET/CT detected nodal metastases with a specificity of 83% for lymph nodes classified as grade 1 and 98% for those classified as grade 2. The sensitivity was moderate, ranging from 60 to 63%. Conclusions: [<sup>18</sup>F]FDG PET/CT has a high specificity for detecting lymph node metastases in HNSCC and therefore must be considered in the nodal clinical staging. |
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| last_indexed | 2024-03-11T00:00:32Z |
| publishDate | 2023-08-01 |
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| series | Diagnostics |
| spelling | doaj.art-bf5583d66f8846b09aa5081edb8a16cd2023-11-19T00:47:59ZengMDPI AGDiagnostics2075-44182023-08-011316263810.3390/diagnostics13162638Comparable Accuracy of Quantitative and Visual Analyses of [<sup>18</sup>F]FDG PET/CT for the Detection of Lymph Node Metastases from Head and Neck Squamous Cell CarcinomaPhilippe d’Abadie0Nicolas Michoux1Thierry Duprez2Sandra Schmitz3Michèle Magremanne4Pascal Van Eeckhout5Olivier Gheysens6Department of Nuclear Medicine, Cliniques Universitaires Saint-Luc, Institut Roi Albert II, Université Catholique de Louvain, 1200 Brussels, BelgiumDepartment of Radiology, Cliniques Universitaires Saint-Luc, Institut Roi Albert II, Université Catholique de Louvain, 1200 Brussels, BelgiumDepartment of Radiology, Cliniques Universitaires Saint-Luc, Institut Roi Albert II, Université Catholique de Louvain, 1200 Brussels, BelgiumDepartment of Head and Neck Surgery, Cliniques Universitaires Saint-Luc, Institut Roi Albert II, Université Catholique de Louvain, 1200 Brussels, BelgiumDepartment of Stomatology and Maxillofacial Surgery, Cliniques Universitaires Saint-Luc, Institut Roi Albert II, Université Catholique de Louvain, 1200 Brussels, BelgiumDepartment of Pathology, Cliniques Universitaires Saint-Luc, Institut Roi Albert II, Université Catholique de Louvain, 1200 Brussels, BelgiumDepartment of Nuclear Medicine, Cliniques Universitaires Saint-Luc, Institut Roi Albert II, Université Catholique de Louvain, 1200 Brussels, BelgiumBackground: In head and neck squamous cell carcinoma (HNSCC), [<sup>18</sup>F]FDG PET/CT is recommended for detecting recurrent disease and in the initial staging for evaluating distant metastases, but its use in detecting cervical lymph metastases remains unclear. The aim of this study is to evaluate and compare the diagnostic accuracy of [<sup>8</sup>F]FDG-PET/CT using visual and semi-quantitative analyses for detecting the nodal involvement in HNSCC. Methods: We analyzed consecutive patients who underwent a preoperative [<sup>18</sup>F]FDG-PET/CT and neck dissection for HNSCC at our tertiary hospital. A blinded evaluation of the [<sup>18</sup>F]FDG uptake in each neck level was performed using a semi-quantitative approach (SUVmax and SUVR) and a visual grading system (uptake superior to the internal jugular vein for grade 1 and superior to the liver for grade 2). Analyses were compared to the histological results. Results: In our 211 patients, analyses demonstrated similar diagnostic accuracy using a semi-quantitative approach or a visual grading system. Regarding the visual grading system, [<sup>18</sup>F]FDG-PET/CT detected nodal metastases with a specificity of 83% for lymph nodes classified as grade 1 and 98% for those classified as grade 2. The sensitivity was moderate, ranging from 60 to 63%. Conclusions: [<sup>18</sup>F]FDG PET/CT has a high specificity for detecting lymph node metastases in HNSCC and therefore must be considered in the nodal clinical staging.https://www.mdpi.com/2075-4418/13/16/2638FDG PET/CThead and neck squamous cell carcinomanodal stagingTNM classificationdiagnostic accuracy |
| spellingShingle | Philippe d’Abadie Nicolas Michoux Thierry Duprez Sandra Schmitz Michèle Magremanne Pascal Van Eeckhout Olivier Gheysens Comparable Accuracy of Quantitative and Visual Analyses of [<sup>18</sup>F]FDG PET/CT for the Detection of Lymph Node Metastases from Head and Neck Squamous Cell Carcinoma Diagnostics FDG PET/CT head and neck squamous cell carcinoma nodal staging TNM classification diagnostic accuracy |
| title | Comparable Accuracy of Quantitative and Visual Analyses of [<sup>18</sup>F]FDG PET/CT for the Detection of Lymph Node Metastases from Head and Neck Squamous Cell Carcinoma |
| title_full | Comparable Accuracy of Quantitative and Visual Analyses of [<sup>18</sup>F]FDG PET/CT for the Detection of Lymph Node Metastases from Head and Neck Squamous Cell Carcinoma |
| title_fullStr | Comparable Accuracy of Quantitative and Visual Analyses of [<sup>18</sup>F]FDG PET/CT for the Detection of Lymph Node Metastases from Head and Neck Squamous Cell Carcinoma |
| title_full_unstemmed | Comparable Accuracy of Quantitative and Visual Analyses of [<sup>18</sup>F]FDG PET/CT for the Detection of Lymph Node Metastases from Head and Neck Squamous Cell Carcinoma |
| title_short | Comparable Accuracy of Quantitative and Visual Analyses of [<sup>18</sup>F]FDG PET/CT for the Detection of Lymph Node Metastases from Head and Neck Squamous Cell Carcinoma |
| title_sort | comparable accuracy of quantitative and visual analyses of sup 18 sup f fdg pet ct for the detection of lymph node metastases from head and neck squamous cell carcinoma |
| topic | FDG PET/CT head and neck squamous cell carcinoma nodal staging TNM classification diagnostic accuracy |
| url | https://www.mdpi.com/2075-4418/13/16/2638 |
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