PREDICTION OF EFFICIENCY OF PYROGENAL THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C
Background. Patients with chronic hepatitis C (CHC) are at risk of developing liver cirrhosis and require adequate antifibrotic therapy. The objective of the study was to develop a method for predicting the response to antifibrotic therapy with pyrogenal in patients with recurrent CHC. Materia...
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| Format: | Article |
| Language: | Belarusian |
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Grodno State Medical University
2018-08-01
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| Series: | Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta |
| Subjects: | |
| Online Access: | http://journal-grsmu.by/index.php/ojs/article/view/2276/2079 |
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| author | Chernyak S. A. Tsyrkunov V. M. Doroshenko Ye. M. Kapytski A. V. |
| author_facet | Chernyak S. A. Tsyrkunov V. M. Doroshenko Ye. M. Kapytski A. V. |
| author_sort | Chernyak S. A. |
| collection | DOAJ |
| description | Background. Patients with chronic hepatitis C (CHC) are at risk of developing liver cirrhosis and require adequate
antifibrotic therapy.
The objective of the study was to develop a method for predicting the response to antifibrotic therapy with pyrogenal
in patients with recurrent CHC.
Material and methods. Before the start of pyrogenal therapy pyrogenal test was performed in 36 patients with CHC,
followed by evaluation of serum levels of taurine, gamma-aminobutyric acid, leucine, 3-methoxy-4-hydroxyphenylglycol
and tryptophan by high-performance liquid chromatography. The patients underwent a course of antifibrotic therapy
with pyrogenal, the dynamics of fibrosis was assessed by the serum TIMP-1 values.
Results. The equation of logistic regression for predicting the effectiveness of antifibrotic therapy of CHC with a
binary response from the communication probit functions was constructed. The model predicts a positive or negative
dynamics of the serum level of TIMP-1 after pyrogenal therapy.
Conclusion. To predict the response to antifibrotic therapy with pyrogenal in patients with CHC, it is recommended
that this model be used in conjunction with the model predicting the dynamics of the APRI index. |
| first_indexed | 2024-12-21T08:34:31Z |
| format | Article |
| id | doaj.art-bf598f2f107e48518a93686c51d1c52e |
| institution | Directory Open Access Journal |
| issn | 2221-8785 2413-0109 |
| language | Belarusian |
| last_indexed | 2024-12-21T08:34:31Z |
| publishDate | 2018-08-01 |
| publisher | Grodno State Medical University |
| record_format | Article |
| series | Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta |
| spelling | doaj.art-bf598f2f107e48518a93686c51d1c52e2022-12-21T19:10:07ZbelGrodno State Medical UniversityŽurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta2221-87852413-01092018-08-0116331131610.25298/2221-8785-2018-16-3-311-316PREDICTION OF EFFICIENCY OF PYROGENAL THERAPY IN PATIENTS WITH CHRONIC HEPATITIS CChernyak S. A.0Tsyrkunov V. M.1Doroshenko Ye. M.2Kapytski A. V.3Educational Institution “Grodno State Medical University”Educational Institution “Grodno State Medical University”Educational Institution «Grodno State Medical University»Educational Institution «Grodno State Medical University»Background. Patients with chronic hepatitis C (CHC) are at risk of developing liver cirrhosis and require adequate antifibrotic therapy. The objective of the study was to develop a method for predicting the response to antifibrotic therapy with pyrogenal in patients with recurrent CHC. Material and methods. Before the start of pyrogenal therapy pyrogenal test was performed in 36 patients with CHC, followed by evaluation of serum levels of taurine, gamma-aminobutyric acid, leucine, 3-methoxy-4-hydroxyphenylglycol and tryptophan by high-performance liquid chromatography. The patients underwent a course of antifibrotic therapy with pyrogenal, the dynamics of fibrosis was assessed by the serum TIMP-1 values. Results. The equation of logistic regression for predicting the effectiveness of antifibrotic therapy of CHC with a binary response from the communication probit functions was constructed. The model predicts a positive or negative dynamics of the serum level of TIMP-1 after pyrogenal therapy. Conclusion. To predict the response to antifibrotic therapy with pyrogenal in patients with CHC, it is recommended that this model be used in conjunction with the model predicting the dynamics of the APRI index.http://journal-grsmu.by/index.php/ojs/article/view/2276/2079Chronic hepatitis Cpyrogenal testantifibrotic therapyefficiency |
| spellingShingle | Chernyak S. A. Tsyrkunov V. M. Doroshenko Ye. M. Kapytski A. V. PREDICTION OF EFFICIENCY OF PYROGENAL THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta Chronic hepatitis C pyrogenal test antifibrotic therapy efficiency |
| title | PREDICTION OF EFFICIENCY OF PYROGENAL THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C |
| title_full | PREDICTION OF EFFICIENCY OF PYROGENAL THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C |
| title_fullStr | PREDICTION OF EFFICIENCY OF PYROGENAL THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C |
| title_full_unstemmed | PREDICTION OF EFFICIENCY OF PYROGENAL THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C |
| title_short | PREDICTION OF EFFICIENCY OF PYROGENAL THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C |
| title_sort | prediction of efficiency of pyrogenal therapy in patients with chronic hepatitis c |
| topic | Chronic hepatitis C pyrogenal test antifibrotic therapy efficiency |
| url | http://journal-grsmu.by/index.php/ojs/article/view/2276/2079 |
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