Osteoporosis and antithrombotic therapy
Anticoagulant and antiplatelet agents are used to prevent stroke and thromboembolic events. There is insufficient data on the effect of these drugs on bone tissue. In addition, the available data are ambiguous, which increases suspicion when used in individuals at high risk of osteoporosis. The arti...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2021-06-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/4173 |
| _version_ | 1797856705538686976 |
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| author | N. V. Brailova E. N. Dudinskaya V. A. Kuznesova O. N. Tkacheva |
| author_facet | N. V. Brailova E. N. Dudinskaya V. A. Kuznesova O. N. Tkacheva |
| author_sort | N. V. Brailova |
| collection | DOAJ |
| description | Anticoagulant and antiplatelet agents are used to prevent stroke and thromboembolic events. There is insufficient data on the effect of these drugs on bone tissue. In addition, the available data are ambiguous, which increases suspicion when used in individuals at high risk of osteoporosis. The article provides data on the effect of anticoagulant and antiplatelet agents on bone metabolism, bone mineral density and the fracture risk. Literature data indicate a negative effect of heparin on bone tissue, which is increase the risk of fractures. Low molecular weight heparins has lower effect on bone tissue than heparin. It is known that vitamin K antagonists significantly affect bone metabolism and markers of bone formation, however, data on the effect on bone mineral density and the risk of fractures are contradictory. Direct oral anticoagulants are relatively safe in relation to bone tissue. Data on the effects of antiplatelet drugs on bone are ambiguous. |
| first_indexed | 2024-04-09T20:46:00Z |
| format | Article |
| id | doaj.art-bf5aa3a08e344db4b3c0ce7f18089e80 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:46:00Z |
| publishDate | 2021-06-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-bf5aa3a08e344db4b3c0ce7f18089e802023-03-29T21:23:36Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202021-06-0126510.15829/1560-4071-2021-41733107Osteoporosis and antithrombotic therapyN. V. Brailova0E. N. Dudinskaya1V. A. Kuznesova2O. N. Tkacheva3Pirogov Russian National Research Medical University, Russian Clinical and Research Center of GerontologyPirogov Russian National Research Medical University, Russian Clinical and Research Center of GerontologyPirogov Russian National Research Medical UniversityPirogov Russian National Research Medical University, Russian Clinical and Research Center of GerontologyAnticoagulant and antiplatelet agents are used to prevent stroke and thromboembolic events. There is insufficient data on the effect of these drugs on bone tissue. In addition, the available data are ambiguous, which increases suspicion when used in individuals at high risk of osteoporosis. The article provides data on the effect of anticoagulant and antiplatelet agents on bone metabolism, bone mineral density and the fracture risk. Literature data indicate a negative effect of heparin on bone tissue, which is increase the risk of fractures. Low molecular weight heparins has lower effect on bone tissue than heparin. It is known that vitamin K antagonists significantly affect bone metabolism and markers of bone formation, however, data on the effect on bone mineral density and the risk of fractures are contradictory. Direct oral anticoagulants are relatively safe in relation to bone tissue. Data on the effects of antiplatelet drugs on bone are ambiguous.https://russjcardiol.elpub.ru/jour/article/view/4173osteoporosisfracturesheparinlow molecular weight heparinswarfarinoral anticoagulants. |
| spellingShingle | N. V. Brailova E. N. Dudinskaya V. A. Kuznesova O. N. Tkacheva Osteoporosis and antithrombotic therapy Российский кардиологический журнал osteoporosis fractures heparin low molecular weight heparins warfarin oral anticoagulants. |
| title | Osteoporosis and antithrombotic therapy |
| title_full | Osteoporosis and antithrombotic therapy |
| title_fullStr | Osteoporosis and antithrombotic therapy |
| title_full_unstemmed | Osteoporosis and antithrombotic therapy |
| title_short | Osteoporosis and antithrombotic therapy |
| title_sort | osteoporosis and antithrombotic therapy |
| topic | osteoporosis fractures heparin low molecular weight heparins warfarin oral anticoagulants. |
| url | https://russjcardiol.elpub.ru/jour/article/view/4173 |
| work_keys_str_mv | AT nvbrailova osteoporosisandantithrombotictherapy AT endudinskaya osteoporosisandantithrombotictherapy AT vakuznesova osteoporosisandantithrombotictherapy AT ontkacheva osteoporosisandantithrombotictherapy |