Neuroprotective Properties of Oleanolic Acid—Computational-Driven Molecular Research Combined with In Vitro and In Vivo Experiments

Neuroprotective Properties of Oleanolic Acid—Computational-Driven Molecular Research Combined with In Vitro and In Vivo Experiments

Oleanolic acid (OA), as a ubiquitous compound in the plant kingdom, is studied for both its neuroprotective and neurotoxic properties. The mechanism of acetylcholinesterase (AChE) inhibitory potential of OA is investigated using molecular dynamic simulations (MD) and docking as well as biomimetic te...

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Bibliographic Details
Main Authors: Katarzyna Stępnik, Wirginia Kukula-Koch, Wojciech Plazinski, Magda Rybicka, Kinga Gawel
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pharmaceuticals
Subjects:
molecular dynamic simulations
molecular docking
neuroprotection
acetylcholinesterase
zebrafish
Online Access:https://www.mdpi.com/1424-8247/16/9/1234

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