Dynamics of Tryptophan Metabolic Pathways in Human Placenta and Placental-Derived Cells: Effect of Gestation Age and Trophoblast Differentiation

Dynamics of Tryptophan Metabolic Pathways in Human Placenta and Placental-Derived Cells: Effect of Gestation Age and Trophoblast Differentiation

L-Tryptophan is an essential amino acid and a precursor of several physiologically active metabolites. In the placenta, the serotonin and kynurenine metabolic pathways of tryptophan metabolism have been identified, giving rise to various molecules of neuroactive or immunoprotective properties, such...

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Bibliographic Details
Main Authors: Rona Karahoda, Cilia Abad, Hana Horackova, Petr Kastner, Jonas Zaugg, Lukas Cerveny, Radim Kucera, Christiane Albrecht, Frantisek Staud
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
fetal programming
trophoblast
tryptophan metabolism
placenta–brain axis
kynurenine pathway
serotonin pathway
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.574034/full

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