Macrophage M1 polarization mediated via the IL-6/STAT3 pathway contributes to apical periodontitis induced by Porphyromonas gingivalis

Macrophage M1 polarization mediated via the IL-6/STAT3 pathway contributes to apical periodontitis induced by Porphyromonas gingivalis

Abstract Objective: To investigate the involvement of IL-6/STAT3 signaling pathway activation in macrophage polarization and bone destruction related to apical periodontitis (AP) stimulated by Porphyromonas gingivalis. Methodology: Macrophage polarization, IL-6/STAT3 expression, and the presence o...

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Bibliographic Details
Main Authors: Xuan Chen, Jinge Dou, Zhuohui Fu, Yang Qiu, Ling Zou, Dingming Huang, Xuelian Tan
Format: Article
Language:English
Published: University of São Paulo 2022-11-01
Series:Journal of Applied Oral Science
Subjects:
IL-6/STAT3
Macrophage
Porphyromonas gingivalis
Apical periodontitis
Bone lesion
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572022000100445&lng=en&tlng=en

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